Neural electrophysiological mechanism of joint hierarchical rule shifting

Neuroreport ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Jiahui Han ◽  
Jie Liu ◽  
Lei Guan ◽  
Wenpei Luo
Keyword(s):  
Electrophysiological Mechanism

Electrophysiological mechanism of the antiarrhythmic action of naloxone

1988 ◽  
Vol 20 ◽  
pp. 125 ◽  
Author(s):  
P. de Bonfioli Cavalcabo ◽  
I. Masini ◽  
P. Bizzarri ◽  
E. Cerbai ◽  
A. Mugelli
Keyword(s):  
Antiarrhythmic Action ◽  
Electrophysiological Mechanism

scholarly journals Recognition Characteristics of Facial and Bodily Expressions: Evidence From ERPs

2021 ◽  
Vol 12 ◽  
Author(s):  
Xiaoxiao Li
Keyword(s):  
Emotion Recognition ◽  
Facial Expressions ◽  
Cognitive Processing ◽  
Natural Environment ◽  
Early Stage ◽  
Event Related Potential ◽  
Emotional Expressions ◽  
Emotional Information ◽  
Prolonged Latency ◽  
Electrophysiological Mechanism

In the natural environment, facial and bodily expressions influence each other. Previous research has shown that bodily expressions significantly influence the perception of facial expressions. However, little is known about the cognitive processing of facial and bodily emotional expressions and its temporal characteristics. Therefore, this study presented facial and bodily expressions, both separately and together, to examine the electrophysiological mechanism of emotional recognition using event-related potential (ERP). Participants assessed the emotions of facial and bodily expressions that varied by valence (positive/negative) and consistency (matching/non-matching emotions). The results showed that bodily expressions induced a more positive P1 component and a shortened latency, whereas facial expressions triggered a more negative N170 and prolonged latency. Among N2 and P3, N2 was more sensitive to inconsistent emotional information and P3 was more sensitive to consistent emotional information. The cognitive processing of facial and bodily expressions had distinctive integrating features, with the interaction occurring in the early stage (N170). The results of the study highlight the importance of facial and bodily expressions in the cognitive processing of emotion recognition.

The Electrophysiological Mechanism of Ventricular Arrhythmias in the Long QT Syndrome

1996 ◽  
Vol 79 (3) ◽  
pp. 474-492 ◽  
Author(s):  
Nabil El-Sherif ◽  
Edward B. Caref ◽  
Hong Yin ◽  
Mark Restivo
Keyword(s):  
Long Qt Syndrome ◽  
Ventricular Arrhythmias ◽  
Long Qt ◽  
Qt Syndrome ◽  
Electrophysiological Mechanism

scholarly journals Reduced Na + and higher K + channel expression and function contribute to right ventricular origin of arrhythmias in Scn5a+/− mice

Open Biology ◽  
2012 ◽  
Vol 2 (6) ◽  
pp. 120072 ◽  
Author(s):  
Claire A. Martin ◽  
Urszula Siedlecka ◽  
Kristin Kemmerich ◽  
Jason Lawrence ◽  
James Cartledge ◽  
...  
Keyword(s):  
Voltage Dependence ◽  
Outward Current ◽  
K Channel ◽  
Transient Outward Current ◽  
Wild Type ◽  
Channel Expression ◽  
Mrna And Protein Expression ◽  
The Right ◽  
And Function ◽  
Electrophysiological Mechanism

Brugada syndrome (BrS) is associated with ventricular tachycardia originating particularly in the right ventricle (RV). We explore electrophysiological features predisposing to such arrhythmic tendency and their possible RV localization in a heterozygotic Scn5a+/− murine model. Na v 1.5 mRNA and protein expression were lower in Scn5a+/− than wild-type (WT), with a further reduction in the RV compared with the left ventricle (LV). RVs showed higher expression levels of K v 4.2, K v 4.3 and KChIP2 in both Scn5a+/− and WT. Action potential upstroke velocity and maximum Na + current ( I Na ) density were correspondingly decreased in Scn5a+/− , with a further reduction in the RV. The voltage dependence of inactivation was shifted to more negative values in Scn5a+/−. These findings are predictive of a localized depolarization abnormality leading to slowed conduction. Persistent Na + current ( I pNa ) density was decreased in a similar pattern to I Na . RV transient outward current ( I to ) density was greater than LV in both WT and Scn5a+/− , and had larger time constants of inactivation. These findings were also consistent with the observation that AP durations were smallest in the RV of Scn5a+/− , fulfilling predictions of an increased heterogeneity of repolarization as an additional possible electrophysiological mechanism for arrhythmogenesis in BrS.

Influence of age on the electrophysiological mechanism of paroxysmal supraventricular tachycardias

2001 ◽  
Vol 78 (3) ◽  
pp. 293-298 ◽  
Author(s):  
B. Brembilla-Perrot ◽  
Pierre Houriez ◽  
Daniel Beurrier ◽  
O. Claudon ◽  
G. Burger ◽  
...  
Keyword(s):  
Supraventricular Tachycardias ◽  
Electrophysiological Mechanism

Levetiracetam effect and electrophysiological mechanism of action in rats with cobalt-induced chronic epilepsy

2019 ◽  
Vol 854 ◽  
pp. 380-386 ◽  
Author(s):  
A. Litvinova Svetlana ◽  
A. Voroninа Tatyana ◽  
N. Nerobkova Lubov ◽  
S. Kutepova Inga ◽  
G. Avakyan Georgii ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
Chronic Epilepsy ◽  
Electrophysiological Mechanism

Adiponectin Ameliorates Cognitive Behaviors and in vivo Synaptic Plasticity Impairments in 3xTg-AD Mice

2021 ◽  
pp. 1-15
Author(s):  
Xu-Dong Yan ◽  
Xue-Song Qu ◽  
Jing Yin ◽  
Jin Qiao ◽  
Jun Zhang ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Cognitive Deficits ◽  
Morris Water Maze Test ◽  
Amyloid Β Protein ◽  
Maze Test ◽  
Anti Inflammatory ◽  
Electrophysiological Mechanism ◽  
Proinflammatory Factors

Background: Cognitive deficit is mainly clinical characteristic of Alzheimer’s disease (AD). Recent reports showed adiponectin and its analogues could reverse cognitive impairments, lower amyloid-β protein (Aβ) deposition, and exert anti-inflammatory effects in different APP/PS1 AD model mice mainly exhibiting amyloid plaque pathology. However, the potential in vivo electrophysiological mechanism of adiponectin protecting against cognitive deficits in AD and the neuroprotective effects of adiponectin on 3xTg-AD mice including both plaque and tangle pathology are still unclear. Objective: To observe the effects of adiponectin treatment on cognitive deficits in 3xTg-AD mice, investigate its potential in vivo electrophysiological mechanism, and testify its anti-inflammatory effects. Methods: Barnes maze test, Morris water maze test, and fear conditioning test were used to evaluate the memory-ameliorating effects of adiponectin on 3xTg-AD mice. In vivo hippocampal electrophysiological recording was used to observe the change of basic synaptic transmission, long-term potentiation, and long-term depression. Immunohistochemistry staining and western blot were used to observe the activation of microglia and astroglia, and the expression levels of proinflammatory factors and anti-inflammtory factor IL-10. Results: Adiponectin treatment could alleviate spatial memory and conditioned fear memory deficits observed in 3xTg-AD mice, improve in vivo LTP depression and LTD facilitation, inhibit overactivation of microglia and astroglia, decrease the expression of proinflammatory factors NF- κB and IL-1β, and increase the expression level of IL-10 in the hippocampus of 3xTg-AD mice. Conclusion: Adiponectin could ameliorate cognitive deficits in 3xTg-AD mice through improving in vivo synaptic plasticity impairments and alleviating neuroinflammation in the hippocampus of 3xTg-AD mice.

Study on the Antiepileptic Effect of Brain Targeting Electric Field on Nano Hydrogel and miR-181

2021 ◽  
Vol 21 (2) ◽  
pp. 1018-1024
Author(s):  
Min Wang ◽  
Jianguo Liu
Keyword(s):  
Electric Field ◽  
Cell Model ◽  
Epileptic Seizures ◽  
Brain Targeting ◽  
Epileptic Focus ◽  
Obvious Effect ◽  
Treatment Of Epilepsy ◽  
Therapeutic Drugs ◽  
Observation Process ◽  
Electrophysiological Mechanism

Epilepsy, as a kind of neurological disease, is harmful to human mental health. There are many problems in the corresponding drugs and treatment methods, such as poor targeting, side effects and drug resistance. The conventional treatment of epilepsy is mainly focused on its corresponding electrophysiological mechanism to limit the discharge of epileptic focus. However, in the clinical and experimental observation process, this method finds that its corresponding target and direction are easily interfered, and its targeting shows poor directionality. Therefore, based on this, this paper will fully combine the electrophysiological mechanism of epilepsy and brain targeting technology, fully analyze the correlation between miR-181 and epilepsy and other nervous system diseases, and construct the epilepsy cell model to provide new ideas for the target and direction. Finally, we will construct a nanoscale hydrogel targeting the electric field, which can rapidly suppress the discharge and release the therapeutic drugs in epileptic seizures, so as to achieve effective treatment for epilepsy. The experimental results show that the new targeting technology proposed in this paper has obvious effect on the treatment of epilepsy.

Sign in / Sign up

Export Citation Format

Share Document