Neurovascular protection of salvianolic acid B and ginsenoside Rg1 combination against acute ischemic stroke in rats

Neuroreport ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Yao Fu ◽  
Rongrong Xing ◽  
Linlin Wang ◽  
Li Yang ◽  
Baohong Jiang
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Salvianolic Acid B ◽  
Ginsenoside Rg1 ◽  
Salvianolic Acid ◽  
Neurovascular Protection

scholarly journals The Safety Evaluation of Salvianolic Acid B and Ginsenoside Rg1 Combination on Mice

2015 ◽  
Vol 16 (12) ◽  
pp. 29345-29356 ◽  
Author(s):  
Qun Zhao ◽  
Min Yang ◽  
Yanping Deng ◽  
Haitao Yu ◽  
Linlin Wang ◽  
...  
Keyword(s):  
Safety Evaluation ◽  
Salvianolic Acid B ◽  
Ginsenoside Rg1 ◽  
Salvianolic Acid

Cardioprotection of salvianolic acid B and ginsenoside Rg1 combination on subacute myocardial infarction and the underlying mechanism

Phytomedicine ◽  
2019 ◽  
Vol 57 ◽  
pp. 255-261 ◽  
Author(s):  
Yuanmin Li ◽  
Linlin Wang ◽  
Zhihui Dong ◽  
Shiying Wang ◽  
Lili Qi ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Underlying Mechanism ◽  
Salvianolic Acid B ◽  
Ginsenoside Rg1 ◽  
Salvianolic Acid

scholarly journals Combined Salvianolic Acid B and Ginsenoside Rg1 Exerts Cardioprotection against Ischemia/Reperfusion Injury in Rats

PLoS ONE ◽  
2015 ◽  
Vol 10 (8) ◽  
pp. e0135435 ◽  
Author(s):  
Yanping Deng ◽  
Min Yang ◽  
Feng Xu ◽  
Qian Zhang ◽  
Qun Zhao ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Salvianolic Acid B ◽  
Ginsenoside Rg1 ◽  
Salvianolic Acid

scholarly journals Ginsenoside Rg1 and Rb1, in combination with salvianolic acid B, play different roles in myocardial infarction in rats

2015 ◽  
Vol 78 (2) ◽  
pp. 114-120 ◽  
Author(s):  
Yanping Deng ◽  
Tingting Zhang ◽  
Fukang Teng ◽  
Defang Li ◽  
Feng Xu ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Salvianolic Acid B ◽  
Ginsenoside Rg1 ◽  
Salvianolic Acid

scholarly journals Effects of Salvianolic Acid B/ginsenoside Rg1 Combination Against Chronic Pulmonary Embolism Induced by Polystyrene Microspheres

2021 ◽  
Vol 69 (4) ◽  
pp. 189-198
Author(s):  
Huimiao Bian ◽  
Na Han ◽  
Linlin Wang ◽  
Xiaoyu Wang ◽  
Kenka Cho ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Right Ventricular ◽  
Cross Sectional Area ◽  
Salvianolic Acid B ◽  
Histopathological Analysis ◽  
Ginsenoside Rg1 ◽  
Sectional Area ◽  
Polystyrene Microspheres ◽  
Cross Sectional ◽  
Salvianolic Acid

Pulmonary embolism (PE) is the most life-threatening complication of venous thromboembolism, but few effective treatments have been discovered to attenuate chronic PE currently. In this study, we investigated the protective effects of salvianolic acid B (SalB) and ginsenoside Rg1 (Rg1) combination (SalB/Rg1) on chronic PE and explored the potential mechanisms. The PE model was induced by 45 μm polystyrene microspheres and 20 mg/kg of SalB/Rg1 was administered to PE rats intraperitoneally. A histopathological analysis of the lungs and heart was performed through hematoxylin and eosin staining and immunohistochemical analysis. The pulmonary index and right ventricular cardiomyocyte cross-sectional area were evaluated. SalB/Rg1 markedly downregulated pulmonary index, attenuated pulmonary interstitial changes, suppressed neutrophil infiltration, prevented collagen deposition, and inhibited MMP-9 activities in the lung. We also found that SalB/Rg1 improved right ventricular hypertrophy accompanied by reducing the cardiomyocyte cross-sectional area. These data suggest that SalB/Rg1 played a protective role against microsphere-induced PE and holds a high potential for the treatment of PE in the future.

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