scholarly journals Magnetoliposomes containing magnesium ferrite nanoparticles as nanocarriers for the model drug curcumin

2018 ◽  
Vol 5 (10) ◽  
pp. 181017 ◽  
Author(s):  
Beatriz D. Cardoso ◽  
Irina S. R. Rio ◽  
Ana Rita O. Rodrigues ◽  
Francisca C. T. Fernandes ◽  
B. G. Almeida ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Fluorescence Quenching ◽  
Magnetic Hyperthermia ◽  
Ferrite Nanoparticles ◽  
Blocking Temperature ◽  
Potential Drug ◽  
Magnesium Ferrite ◽  
Superparamagnetic Behaviour ◽  
Maximum Magnetization ◽  
Model Drug

Magnesium ferrite nanoparticles, with diameters around 25 nm, were synthesized by coprecipitation method. The magnetic properties indicate a superparamagnetic behaviour, with a maximum magnetization of 16.2 emu g −1 , a coercive field of 22.1 Oe and a blocking temperature of 183.2 K. These MgFe 2 O 4 nanoparticles were used to produce aqueous and solid magnetoliposomes, with sizes below 130 nm. The potential drug curcumin was successfully incorporated in these nanosystems, with high encapsulation efficiencies (above 89%). Interaction by fusion between both types of drug-loaded magnetoliposomes (with or without PEGylation) and models of biological membranes was demonstrated, using FRET or fluorescence quenching assays. These results point to future applications of magnetoliposomes containing MgFe 2 O 4 nanoparticles in cancer therapy, allowing combined magnetic hyperthermia and chemotherapy.

scholarly journals Stealth Magnetoliposomes Based on Calcium-Substituted Magnesium Ferrite Nanoparticles for Curcumin Transport and Release

2020 ◽  
Vol 21 (10) ◽  
pp. 3641 ◽  
Author(s):  
Beatriz D. Cardoso ◽  
Ana Rita O. Rodrigues ◽  
Bernardo G. Almeida ◽  
Carlos O. Amorim ◽  
Vítor S. Amaral ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Release ◽  
Natural Compound ◽  
Controlled Drug Release ◽  
Magnetic Hyperthermia ◽  
Ferrite Nanoparticles ◽  
Pharmacological Properties ◽  
Magnesium Ferrite ◽  
Superparamagnetic Properties ◽  
Over Time

Despite the promising pharmacological properties of curcumin, the transport and effective release of curcumin is still a challenge. The advances in functionalized nanocarriers for curcumin have also been motivated by the anticancer activity of this natural compound, aiming at targeted therapies. Here, stealth (aqueous and solid) magnetoliposomes containing calcium-substituted magnesium ferrite nanoparticles, CaxMg1−xFe2O4 (with x = 0.25, 0.50, 0.75) were developed as nanocarriers for curcumin. The magnetic nanoparticles exhibit superparamagnetic properties and crystalline structure, with sizes below 10 nm. The magnetoliposomes based on these nanoparticles have hydrodynamic diameters around or below 150 nm and a low polydispersity. The influence of an alternating magnetic field (AMF) on drug release over time was evaluated and compared with curcumin release by diffusion. The results suggest the potential of drug-loaded magnetoliposomes as nanocarriers that can be magnetically guided to the tumor sites and act as agents for a synergistic effect combining magnetic hyperthermia and controlled drug release.

scholarly journals Tuning of spinel magnesium ferrite nanoparticles with enhanced magnetic properties

RSC Advances ◽  
2018 ◽  
Vol 8 (68) ◽  
pp. 39177-39181 ◽  
Author(s):  
Liyun Zheng ◽  
Kan Fang ◽  
Meiling Zhang ◽  
Zhixian Nan ◽  
Lixin Zhao ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Solvothermal Method ◽  
Ferrite Nanoparticles ◽  
Magnesium Ferrite

Monodispersed magnesium ferrite nanoparticles with enhanced magnetic properties were successfully fabricated by a simple solvothermal method without employing any templates, complex apparatus or techniques.

scholarly journals Synthesis and Characterization of CeGdZn-Ferrite Nanoparticles as Magnetic Hyperthermia Application Agents

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Saleh S. Hayek
Keyword(s):  
Magnetic Properties ◽  
Magnetic Hyperthermia ◽  
Ferrite Nanoparticles ◽  
Synthesis And Characterization ◽  
X Ray Diffraction ◽  
X Ray ◽  
Magnetic Nanomaterial ◽  
Encapsulated Nanoparticles

This study focuses on the synthesis and characterization of a magnetic nanomaterial used in magnetic hyperthermia. Cerium gadolinium zinc-iron (CeGdZnFe) magnetic nanoparticles were synthesized by a coprecipitation method for application as magnetic hyperthermia agents. Determination of phase purity and their identification was achieved by X-ray diffraction studies using a Phillips powder diffractometer with Cu Kα radiation. Typical TEM micrographs of the dispersion of CeGdZn-ferrite nanoparticles and CeGdZn-ferrite PEG-encapsulated nanoparticles in ethanol deposited over a Cu grid were taken as part of the characterization techniques to be used for newly developed materials. It was then fitted by a Gaussian distribution with mean diameter dm ±1.0 nm. The investigation of magnetic properties showed that adjusting, Gd and Zn contributes to the nanoparticles added to the adjustment of all magnetic properties of CeGdZnFe.

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