Synthesis and in Vitro Evaluation of Magnesium Ferrite Nanoparticles for Application to Magnetic Hyperthermia

Despite the promising pharmacological properties of curcumin, the transport and effective release of curcumin is still a challenge. The advances in functionalized nanocarriers for curcumin have also been motivated by the anticancer activity of this natural compound, aiming at targeted therapies. Here, stealth (aqueous and solid) magnetoliposomes containing calcium-substituted magnesium ferrite nanoparticles, CaxMg1−xFe2O4 (with x = 0.25, 0.50, 0.75) were developed as nanocarriers for curcumin. The magnetic nanoparticles exhibit superparamagnetic properties and crystalline structure, with sizes below 10 nm. The magnetoliposomes based on these nanoparticles have hydrodynamic diameters around or below 150 nm and a low polydispersity. The influence of an alternating magnetic field (AMF) on drug release over time was evaluated and compared with curcumin release by diffusion. The results suggest the potential of drug-loaded magnetoliposomes as nanocarriers that can be magnetically guided to the tumor sites and act as agents for a synergistic effect combining magnetic hyperthermia and controlled drug release.

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Preparation, characterization and in vitro evaluation of magnesium ferrite superparamagnetic nanoparticles as a novel radiosensitizer of breast cancer cells

Ceramics International ◽

10.1016/j.ceramint.2020.04.057 ◽

2020 ◽

Vol 46 (11) ◽

pp. 17577-17583 ◽

Cited By ~ 7

Author(s):

Alireza Meidanchi ◽

Anna Motamed

Keyword(s):

Breast Cancer ◽

Cancer Cells ◽

Breast Cancer Cells ◽

Superparamagnetic Nanoparticles ◽

Magnesium Ferrite ◽

In Vitro Evaluation

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Synthesis and magnetic hyperthermia properties of zwitterionic dopamine sulfonate ligated magnesium ferrite and zinc ferrite nanoparticles

Journal of Materials Science Materials in Electronics ◽

10.1007/s10854-020-05005-y ◽

2021 ◽

Author(s):

V. Vijayakanth ◽

V. Vinodhini ◽

A. Aparna ◽

M. S. Malavika ◽

C. Krishnamoorthi

Keyword(s):

Zinc Ferrite ◽

Magnetic Hyperthermia ◽

Ferrite Nanoparticles ◽

Magnesium Ferrite

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In vitro application of Mn-ferrite nanoparticles as novel magnetic hyperthermia agents

Journal of Materials Chemistry B ◽

10.1039/c4tb01017e ◽

2014 ◽

Vol 2 (47) ◽

pp. 8390-8398 ◽

Cited By ~ 32

Author(s):

Antonios Makridis ◽

Konstantina Topouridou ◽

Magdalini Tziomaki ◽

Despoina Sakellari ◽

Konstantinos Simeonidis ◽

...

Keyword(s):

Magnetic Hyperthermia ◽

Ferrite Nanoparticles

A hyperthermia heating agent of Mn-ferrite MNPs is selectively harmful for Saos-2 osteoblasts.

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In-vitro evaluation of layered double hydroxide–Fe3O4 magnetic nanohybrids for thermo-chemotherapy

New Journal of Chemistry ◽

10.1039/c5nj01701g ◽

2016 ◽

Vol 40 (1) ◽

pp. 423-433 ◽

Cited By ~ 20

Author(s):

EswaraVara Prasadarao Komarala ◽

Saumya Nigam ◽

Mohammed Aslam ◽

Dhirendra Bahadur

Keyword(s):

Layered Double Hydroxide ◽

Layered Double Hydroxides ◽

Magnetic Hyperthermia ◽

Threshold Temperature ◽

In Vitro Evaluation ◽

Double Hydroxide ◽

Double Hydroxides ◽

Magnetic Nanohybrids

Combining layered double hydroxides with Fe3O4 nanoparticles resulted in the desired “cut-off switch” for threshold temperature towards magnetic hyperthermia.

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Magnetoliposomes containing magnesium ferrite nanoparticles as nanocarriers for the model drug curcumin

Royal Society Open Science ◽

10.1098/rsos.181017 ◽

2018 ◽

Vol 5 (10) ◽

pp. 181017 ◽

Cited By ~ 11

Author(s):

Beatriz D. Cardoso ◽

Irina S. R. Rio ◽

Ana Rita O. Rodrigues ◽

Francisca C. T. Fernandes ◽

B. G. Almeida ◽

...

Keyword(s):

Magnetic Properties ◽

Fluorescence Quenching ◽

Magnetic Hyperthermia ◽

Ferrite Nanoparticles ◽

Blocking Temperature ◽

Potential Drug ◽

Magnesium Ferrite ◽

Superparamagnetic Behaviour ◽

Maximum Magnetization ◽

Model Drug

Magnesium ferrite nanoparticles, with diameters around 25 nm, were synthesized by coprecipitation method. The magnetic properties indicate a superparamagnetic behaviour, with a maximum magnetization of 16.2 emu g −1 , a coercive field of 22.1 Oe and a blocking temperature of 183.2 K. These MgFe 2 O 4 nanoparticles were used to produce aqueous and solid magnetoliposomes, with sizes below 130 nm. The potential drug curcumin was successfully incorporated in these nanosystems, with high encapsulation efficiencies (above 89%). Interaction by fusion between both types of drug-loaded magnetoliposomes (with or without PEGylation) and models of biological membranes was demonstrated, using FRET or fluorescence quenching assays. These results point to future applications of magnetoliposomes containing MgFe 2 O 4 nanoparticles in cancer therapy, allowing combined magnetic hyperthermia and chemotherapy.

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