scholarly journals Experimental chemotherapy of typhus Anti-rickettsial action of p -sulphonamidobenzamidine and related compounds

1946 ◽  
Vol 133 (870) ◽  
pp. 20-62 ◽  
Keyword(s):  
Biological Activity ◽  
Therapeutic Action ◽  
Experimental Chemotherapy ◽  
Related Compounds

The discovery of the pronounced anti-rickettsial activity of p -sulphonamidobenzamidine on experimental typhus infections in mice has led to a search for compounds of enhanced therapeutic action. A large number of compounds have been prepared in development of the sulphonamido-amidine structure, but anti-rickettsial activity has been found to be confined to about a dozen substances intimately related to p -sulphonamidobenzamidine, only one, namely, p -sulphonamidobenzamidoxime, having a very slightly superior therapeutic action. The significance of the discovery of yet another sulphonamide type with pronounced biological activity is discussed.

Cytosporones and Related Compounds, A Review: Isolation, Biosynthesis, Synthesis and Biological Activity of Promising Fungal Resorcinolic Lipids

2015 ◽  
Vol 12 (5) ◽  
pp. 618-638 ◽  
Author(s):  
Alisson Meza ◽  
Edson Anjos dos Santos ◽  
Roberto Silva Gomes ◽  
Dênis de Lima ◽  
Adilson Beatriz
Keyword(s):  
Biological Activity ◽  
Resorcinolic Lipids ◽  
Related Compounds

scholarly journals Az ösztrogénmetabolom biológiai és klinikai jelentősége lokális folyamatokban

2017 ◽  
Vol 158 (24) ◽  
pp. 929-937
Author(s):  
Krisztián Kovács ◽  
Barna Vásárhelyi ◽  
Katalin Mészáros ◽  
Attila Patócs ◽  
Gellért Karvaly
Keyword(s):  
Biological Activity ◽  
Clinical Significance ◽  
Physiological Role ◽  
Tissue Homeostasis ◽  
Diagnostic Significance ◽  
Peripheral Tissues ◽  
Breakdown Process ◽  
Specific Manner ◽  
Related Compounds

Abstract: Considerable knowledge has been gathered on the physiological role of estrogens. However, fairly little information is available on the role of compounds produced in the breakdown process of estrone and estradiol wich may play a role in various diseases associated with estrogen impact. To date, approximately 15 extragonadal estrogen-related compounds have been identified. These metabolites may exert protective, or, instead, pro-inflammatory and/or pro-oncogenic activity in a tissue-specific manner. Systemic and local estrogen metabolite levels are not necesserily correlated, which may promote the diagnostic significance of the locally produced estrogen metabolites in the future. The aim of the present study is a bibliographic review of the extragonadal metabolome in peripheral tissues, and to highlight the role of the peripheral tissue homeostasis of estrogens as well as the non-hormonal biological activity and clinical significance of the estrogen metabolome. Orv Hetil. 2017; 158(24): 929–937.

scholarly journals Biological activity and mechanisms of therapeutic action of rosmarinic acid, luteolin and its sulphated derivatives

2016 ◽  
Vol 62 (1) ◽  
pp. 22-30 ◽  
Author(s):  
A.M. Popov ◽  
O.N. Krivoshapko ◽  
A.A. Klimovich ◽  
A.A. Artyukov
Keyword(s):  
Type 2 Diabetes ◽  
Biological Activity ◽  
Lipid Metabolism ◽  
Phenolic Compounds ◽  
Rosmarinic Acid ◽  
Therapeutic Potential ◽  
Experimental Studies ◽  
Therapeutic Action ◽  
Carbohydrate And Lipid Metabolism

The review considers recent experimental studies of biological activity and mechanisms of therapeutic action of rosmarinic acid, luteolin and its sulfated derivatives in diseases associated with disorders of carbohydrate and lipid metabolism. Particular attention is focused on the results of studies showing a high therapeutic potential of these phenolic compounds in their prophylactic and therapeutic use at experimental modeling of type 2 diabetes and hyperlipidemia. Based on the analysis of our results and the literature data putative mechanisms of therapeutic action of rosmarinic acid, luteolin and its sulfated derivatives have been proposed.

Chemical structure and biological activity of hormones and related compounds

2007 ◽  
pp. 405-489
Author(s):  
K. Bankowski ◽  
D. Brandenburg ◽  
D. Gillessen ◽  
U. Ludescher ◽  
M. Manning ◽  
...  
Keyword(s):  
Biological Activity ◽  
Chemical Structure ◽  
Related Compounds

Chemical structure and biological activity of hormones and related compounds

2007 ◽  
pp. 427-493
Author(s):  
A. Bodanszky ◽  
M. Bodanszky ◽  
D. Brandenburg ◽  
D. Gillessen ◽  
U. Ludescher ◽  
...  
Keyword(s):  
Biological Activity ◽  
Chemical Structure ◽  
Related Compounds

Cytokinins: Synthesis and biological activity of zeatin esters and related compounds

1971 ◽  
Vol 10 (2) ◽  
pp. 275-280 ◽  
Author(s):  
Ruth Y. Schmitz ◽  
Folke Skoog ◽  
Sidney M. Hecht ◽  
Nelson J. Leonard
Keyword(s):  
Biological Activity ◽  
Related Compounds

ChemInform Abstract: Isocytosine H2-Receptor Histamine Antagonists. Part 4. Synthesis and Biological Activity of Donetidine (SKPF 93574) and Related Compounds.

ChemInform ◽  
2010 ◽  
Vol 25 (1) ◽  
pp. no-no
Author(s):  
T. H. BROWN ◽  
R. C. BLAKEMORE ◽  
G. J. DURANT ◽  
C. R. GANELLIN ◽  
M. E. PARSONS ◽  
...  
Keyword(s):  
Biological Activity ◽  
Histamine Antagonists ◽  
H2 Receptor ◽  
Related Compounds

ChemInform Abstract: Purines. Part 51. Synthesis and Biological Activity of Hypoxanthine 7- N-Oxide and Related Compounds.

ChemInform ◽  
2010 ◽  
Vol 23 (38) ◽  
pp. no-no
Author(s):  
K. OGAWA ◽  
M. NISHII ◽  
F. NOHARA ◽  
T. SAITO ◽  
T. ITAYA ◽  
...  
Keyword(s):  
Biological Activity ◽  
Related Compounds
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