scholarly journals Herpes Simplex Virus-induced Enhancement of Mitochondrial DNA Synthesis in the Absence of Virus Replication

1974 ◽  
Vol 25 (3) ◽  
pp. 457-463 ◽  
Author(s):  
K. Radsak ◽  
M. Albring
Keyword(s):  
Mitochondrial Dna ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Dna Synthesis ◽  
Virus Replication ◽  
Simplex Virus ◽  
Mitochondrial Dna Synthesis

Corrigendum to “Cetylpyridinium chloride blocks herpes simplex virus replication in gingival fibroblasts” [Anti. Res. 179 (2020) 104818]

2021 ◽  
Vol 188 ◽  
pp. 105022
Author(s):  
Diana M. Alvarez ◽  
Luisa F. Duarte ◽  
Nicolas Corrales ◽  
Patricio C. Smith ◽  
Pablo A. González
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Replication ◽  
Cetylpyridinium Chloride ◽  
Gingival Fibroblasts ◽  
Simplex Virus

scholarly journals Control of Herpes Simplex Virus Replication Is Mediated through an Interferon Regulatory Factor 3-Dependent Pathway

2009 ◽  
Vol 83 (23) ◽  
pp. 12399-12406 ◽  
Author(s):  
Vineet D. Menachery ◽  
David A. Leib
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Replication ◽  
Early Recognition ◽  
Critical Role ◽  
Type I ◽  
Type I Ifn ◽  
Regulatory Factor ◽  
Simplex Virus ◽  
Hsv 1

ABSTRACT The type I interferon (IFN) cascade is critical in controlling viral replication and pathogenesis. Recognition pathways triggered by viral infection rapidly induce the type I IFN cascade, often in an IFN regulatory factor 3 (IRF-3)-dependent fashion. This dependence predicts that loss of IRF-3 would render early recognition pathways inoperative and thereby impact virus replication, but this has not been observed previously with herpes simplex virus type 1 (HSV-1) in vitro. In this study, HSV-1-infected IRF-3−/− bone marrow-derived dendritic cells (BMDCs) and macrophages supported increased HSV replication compared to control cells. In addition, IRF-3-deficient BMDCs exhibited delayed type I IFN synthesis compared to control cells. However, while IFN pretreatment of IRF-3−/− BMDCs resulted in reduced virus titers, a far greater reduction was seen after IFN treatment of wild-type cells. This suggests that even in the presence of exogenously supplied IFN, IRF-3−/− BMDCs are inherently defective in the control of HSV-1 replication. Together, these results demonstrate a critical role for IRF-3-mediated pathways in controlling HSV-1 replication in cells of the murine immune system.

scholarly journals Viral DNA synthesis is required for the efficient expression of specific herpes simplex virus type 1 mRNA species

Virology ◽  
1980 ◽  
Vol 101 (1) ◽  
pp. 10-24 ◽  
Author(s):  
Louis E. Holland ◽  
Kevin P. Anderson ◽  
Charles Shipman ◽  
Edward K. Wagner
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Dna Synthesis ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Viral Dna ◽  
Mrna Species ◽  
Efficient Expression ◽  
Simplex Virus
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