scholarly journals Identifying states of collateral sensitivity during the evolution of therapeutic resistance in Ewing’s sarcoma

Author(s):  
Jessica A. Scarborough ◽  
Erin McClure ◽  
Peter Anderson ◽  
Andrew Dhawan ◽  
Arda Durmaz ◽  
...  

SummaryAdvances in the treatment of Ewing’s sarcoma (EWS) are desperately needed, particularly in the case of metastatic disease. A deeper understanding of collateral sensitivity, where the evolution of therapeutic resistance to one drug aligns with sensitivity to another drug, may improve our ability to effectively target this disease. For the first time in a solid tumor, we produced a temporal collateral sensitivity map that demonstrates the evolution of collateral sensitivity and resistance in EWS. We found that the evolution of collateral resistance was predictable with some drugs, but had significant variation in response to other drugs. Using this map of temporal collateral sensitivity in EWS, we can see that the path towards collateral sensitivity is not always repeatable, nor is there always a clear trajectory towards resistance or sensitivity. Identifying transcriptomic changes that accompany these states of transient collateral sensitivity could improve treatment planning for EWS patients.

iScience ◽  
2020 ◽  
Vol 23 (7) ◽  
pp. 101293
Author(s):  
Jessica A. Scarborough ◽  
Erin McClure ◽  
Peter Anderson ◽  
Andrew Dhawan ◽  
Arda Durmaz ◽  
...  

Oncogene ◽  
2009 ◽  
Vol 28 (46) ◽  
pp. 4126-4132 ◽  
Author(s):  
W Luo ◽  
K Gangwal ◽  
S Sankar ◽  
K M Boucher ◽  
D Thomas ◽  
...  

ORL ro ◽  
2017 ◽  
Vol 2 (35) ◽  
pp. 24
Author(s):  
Daniel Mirea ◽  
Loredana Mitran ◽  
Daniela Safta ◽  
Cornelia Niţipir ◽  
Bogdan Mocanu ◽  
...  

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