Cerebellar modulation of prefrontal-hippocampal gamma coherence during spatial working memory decisions

ABSTRACTThe medial prefrontal cortex (mPFC) and dorsal hippocampal CA1 region (dCA1) in rodents show increased coherence of neuronal oscillations during decisions in learned spatial working memory (SWM) tasks and the coherence changes reflect decision outcome. However, how coherence is controlled is unknown. We found in mice that decision related gamma coherence modulation between the mPFC and dCA1 and normal SWM performance required an intact cerebellum. Optogenetic activation of the cerebellar lobulus simplex impaired decision-related mPFC-dCA1 coherence modulation and SWM performance. Our findings reveal a role for the cerebellum in the task-specific modulation of coherence between cerebral cortical areas as possible mechanism of cerebellar cognitive function.

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Delay-dependent impairment of spatial working memory with inhibition of NR2B-containing NMDA receptors in hippocampal CA1 region of rats

Molecular Brain ◽

10.1186/1756-6606-6-13 ◽

2013 ◽

Vol 6 (1) ◽

pp. 13 ◽

Cited By ~ 29

Author(s):

Xue-Han Zhang ◽

Shu-Su Liu ◽

Feng Yi ◽

Min Zhuo ◽

Bao-Ming Li

Keyword(s):

Working Memory ◽

Nmda Receptors ◽

Spatial Working Memory ◽

Ca1 Region ◽

Hippocampal Ca1 Region ◽

Hippocampal Ca1 ◽

Delay Dependent

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Two-photon calcium imaging of medial prefrontal cortex and hippocampus without cortical invasion

10.1101/119404 ◽

2017 ◽

Cited By ~ 2

Author(s):

Masashi Kondo ◽

Kenta Kobayashi ◽

Masamichi Ohkura ◽

Junichi Nakai ◽

Masanori Matsuzaki

Keyword(s):

Prefrontal Cortex ◽

Medial Prefrontal Cortex ◽

Neural Activity ◽

Calcium Imaging ◽

Cortical Surface ◽

Intact Mouse ◽

Two Photon ◽

Ca1 Region ◽

Hippocampal Ca1 Region ◽

Hippocampal Ca1

AbstractIn vivo two-photon calcium imaging currently allows us to observe the activity of multiple neurons up to ∼900 μm below the cortical surface without cortical invasion. However, many other important brain areas are located deeper than this. Here, we used a 1100 nm laser, which underfilled the back aperture of the objective, and red genetically encoded calcium indicators to establish two-photon calcium imaging of the intact mouse brain and detect neural activity up to 1200 μm from the cortical surface. This imaging was obtained from the medial prefrontal cortex (the prelimbic area) and the hippocampal CA1 region. We found that the neural activity related to reward prediction is higher in the prelimbic area than in layer 2/3 of the secondary motor area, while it is negligible in the hippocampal CA1 region. Reducing the invasiveness of imaging is an important strategy to reveal the brain processes active in cognition and memory.

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Activation of CaM kinase IV and CREB phosphorylation in LTP at rat hippocampal CA1 region

Neuroscience Research ◽

10.1016/s0168-0102(00)81238-9 ◽

2000 ◽

Vol 38 ◽

pp. S65

Author(s):

J Kasahara

Keyword(s):

Cam Kinase ◽

Creb Phosphorylation ◽

Ca1 Region ◽

Hippocampal Ca1 Region ◽

Hippocampal Ca1 ◽

Cam Kinase Iv

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Faculty Opinions recommendation of Bump attractor dynamics in prefrontal cortex explains behavioral precision in spatial working memory.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718262129.793494533 ◽

2014 ◽

Author(s):

Nicolas Brunel ◽

Elisa Tartaglia

Keyword(s):

Working Memory ◽

Prefrontal Cortex ◽

Spatial Working Memory ◽

Attractor Dynamics

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The role of prefrontal cortex in working memory: examining the contents of consciousness

Philosophical Transactions of the Royal Society B Biological Sciences ◽

10.1098/rstb.1998.0334 ◽

1998 ◽

Vol 353 (1377) ◽

pp. 1819-1828 ◽

Cited By ~ 159

Author(s):

◽

S. M. Courtney ◽

L. Petit ◽

J. V. Haxby ◽

L. G. Ungerleider

Keyword(s):

Working Memory ◽

Prefrontal Cortex ◽

Visual Processing ◽

Right Hemisphere ◽

Functional Organization ◽

Spatial Working Memory ◽

Domain Specificity ◽

Long Term Memory ◽

Present Evidence ◽

The Right

Working memory enables us to hold in our ‘mind's eye’ the contents of our conscious awareness, even in the absence of sensory input, by maintaining an active representation of information for a brief period of time. In this review we consider the functional organization of the prefrontal cortex and its role in this cognitive process. First, we present evidence from brain–imaging studies that prefrontal cortex shows sustained activity during the delay period of visual working memory tasks, indicating that this cortex maintains on–line representations of stimuli after they are removed from view. We then present evidence for domain specificity within frontal cortex based on the type of information, with object working memory mediated by more ventral frontal regions and spatial working memory mediated by more dorsal frontal regions. We also propose that a second dimension for domain specificity within prefrontal cortex might exist for object working memory on the basis of the type of representation, with analytic representations maintained preferentially in the left hemisphere and image–based representations maintained preferentially in the right hemisphere. Furthermore, we discuss the possibility that there are prefrontal areas brought into play during the monitoring and manipulation of information in working memory in addition to those engaged during the maintenance of this information. Finally, we consider the relationship of prefrontal areas important for working memory, both to posterior visual processing areas and to prefrontal areas associated with long–term memory.

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