Cholesterol Metabolism—Impacts on SARS-CoV-2 Infection Prognosis, Entry, and Antiviral Therapies

2020 ◽  
Author(s):  
Congwen Wei ◽  
Luming Wan ◽  
Yanhong Zhang ◽  
Chen Fan ◽  
Qiulin Yan ◽  
...  
Keyword(s):  
Cholesterol Metabolism ◽  
Scavenger Receptor ◽  
Hdl Cholesterol ◽  
Lung Cells ◽  
Type I ◽  
Antiviral Therapies ◽  
Scavenger Receptor Class ◽  
Global Pandemic ◽  
Class B ◽  
Clinically Significant

AbstractThe recently emerged pathogenic SARS-coronavirus 2 (SARS-CoV-2) has spread rapidly, leading to a global pandemic. In this study, we show that SARS-CoV-2 infection was associated with clinically significant lower level of HDL cholesterol (HDL-C), which can be used as indicators of disease severity and poor prognosis. Importantly, we found the spike protein of SARS-CoV-2 (SARS-2-S) bound to HDL. Antagonists of HDL receptor-Scavenger receptor class B type I (SR-B1), strongly inhibited SARS-CoV-2 infection. Notably, the lipids transfer function of SR-B1 was indispensable for this inhibition, offering explanations for the reduced serum HDL level observed in COVID-19 patients. Basing on findings here, we speculate that SR-B1-mediated pulmonary HDL-vitamin E uptake could participate in mediating SARS-CoV-2 infection of lung cells, and the unique expression profile of SR-B1 may also affect SARS-CoV-2 cell and tissue tropism. These findings might help to provide further insights into viral transmission, pathological characteristics and reveal therapeutic targets.Graphical Abstract

scholarly journals Scavenger receptor class B type I regulates cellular cholesterol metabolism and cell signaling associated with breast cancer development

2013 ◽  
Vol 15 (5) ◽  
Author(s):  
Christiane Danilo ◽  
Jorge L Gutierrez-Pajares ◽  
Maria Antonietta Mainieri ◽  
Isabelle Mercier ◽  
Michael P Lisanti ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Signaling ◽  
Cholesterol Metabolism ◽  
Scavenger Receptor ◽  
Cancer Development ◽  
Type I ◽  
Cellular Cholesterol ◽  
Breast Cancer Development ◽  
Scavenger Receptor Class ◽  
Class B

scholarly journals Association between HaeIII polymorphism of scavenger receptor class B type I gene and plasma HDL-cholesterol concentration

2002 ◽  
Vol 39 (5) ◽  
pp. 478-481 ◽  
Author(s):  
Seung Ho Hong ◽  
Young-Ree Kim ◽  
Yeo Min Yoon ◽  
Won Ki Min ◽  
Sa Il Chun ◽  
...  
Keyword(s):  
Plasma Lipids ◽  
Scavenger Receptor ◽  
Hdl Cholesterol ◽  
Cholesterol Concentration ◽  
Type I ◽  
Common Allele ◽  
Scavenger Receptor Class ◽  
Class B ◽  
The Common ◽  
I Gene

Background: Evidence has recently been found for significant associations between genetic variation within the scavenger receptor class B type I gene ( SR-BI), plasma lipids and anthropometric measurements in healthy Caucasians. The present case-control study was conducted to determine whether there is an association between three polymorphisms identified by the restriction endonucleases HaeIII, AluI and ApaI of SR-BI and coronary artery disease (CAD) in Korean subjects. Methods: DNA was extracted from 137 subjects with CAD and 124 age-matched controls; it was amplified using the polymerase chain reaction. Individual alleles at each of the three polymorphic sites were identified by digestion with the appropriate restriction enzyme. Results: Only a single allele was identified at the AluI and ApaI polymorphic sites. The frequency of the common (+) allele at the HaeIII polymorphic site was higher in CAD patients than in the controls ( P = 0·001). The concentrations of plasma HDL-cholesterol and apolipoprotein AI also varied significantly among HaeIII genotypes in the CAD patients. The common (+) allele of the HaeIII polymorphism was associated with a lower body mass index in female controls. Conclusions: Allele frequencies of the AluI and ApaI polymorphisms in this study were different to those in a Caucasian population studied previously, suggesting a difference in the genetic background. Further comparative studies of SR-BI polymorphism in other racial or ethnic groups should therefore prove to be of value.

Identification of Scavenger Receptor Class B Type I in the Hepatocytes of Hypercholesterolemic Rats

2001 ◽  
Vol 7 (S2) ◽  
pp. 642-643
Author(s):  
J. Y. Wang ◽  
Y. W. Lee ◽  
H. Y. Hsiao ◽  
W. T. Chao ◽  
V. C. Yang
Keyword(s):  
Scavenger Receptor ◽  
Hdl Cholesterol ◽  
High Density Lipoproteins ◽  
High Cholesterol Diet ◽  
Type I ◽  
Sprague Dawley ◽  
Long Term Effects ◽  
High Cholesterol ◽  
Scavenger Receptor Class ◽  
Class B

The levels of plasma high density lipoproteins (HDL) are inversely related to the incidence of atherosclerosis and coronary heart disease. This protective effect of HDL is thought to be involved in the reverse transport of cholesterol from peripheral tissue to the liver. The scavenger receptor class B type 1 (SR-BI) is the first HDL receptor that can mediate the selective uptake of HDL cholesterol in steroidogenic tissues and in liver. The expression of SR-BI in liver appears to be responsive to changes in the hormonal status and in the levels of HDL cholesterol. However, long-term effects of high-cholesterol diet on the SR-BI expression in liver parenchymal cells and KupfFer cells have not been studied. to investigate the in vivo effects of liver-specific SR-BI expression on lipid metabolism, we fed male Sprague-Dawley rats with high-cholesterol or normal diet for 1 and 12 months.

scholarly journals Variants in Scavenger Receptor Class B Type I Gene Are Associated with HDL Cholesterol Levels in Younger Women

2007 ◽  
Vol 64 (2) ◽  
pp. 107-113 ◽  
Author(s):  
Caroline G.P. Roberts ◽  
Haiqing Shen ◽  
Braxton D. Mitchell ◽  
Coleen M. Damcott ◽  
Alan R. Shuldiner ◽  
...  
Keyword(s):  
Scavenger Receptor ◽  
Hdl Cholesterol ◽  
Type I ◽  
Younger Women ◽  
Cholesterol Levels ◽  
Scavenger Receptor Class ◽  
Class B ◽  
I Gene

Quercetin induces the selective uptake of HDL-cholesterol via promoting SR-BI expression and the activation of the PPARγ/LXRα pathway

2018 ◽  
Vol 9 (1) ◽  
pp. 624-635 ◽  
Author(s):  
Kun Ren ◽  
Ting Jiang ◽  
Guo-Jun Zhao
Keyword(s):  
Reverse Cholesterol Transport ◽  
Scavenger Receptor ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Cholesterol Transport ◽  
Type I ◽  
Lipid Uptake ◽  
Scavenger Receptor Class ◽  
Class B ◽  
Selective Lipid Uptake

Reverse cholesterol transport (RCT) is the process to deliver cholesterol to the liver for further excretion and involves scavenger receptor class B type I (SR-BI)-mediated selective lipid uptake (SLU) from high-density lipoprotein cholesterol (HDL-C).

scholarly journals HDL modification by secretory phospholipase A2 promotes scavenger receptor class B type I interaction and accelerates HDL catabolism

2000 ◽  
Vol 41 (11) ◽  
pp. 1849-1857 ◽  
Author(s):  
Frederick C. de Beer ◽  
Patrice M. Connell ◽  
J. Yu ◽  
Maria C. de Beer ◽  
Nancy R. Webb ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Scavenger Receptor ◽  
Type I ◽  
Secretory Phospholipase A2 ◽  
Secretory Phospholipase ◽  
Scavenger Receptor Class ◽  
Class B
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