scholarly journals Indexing Cerebrovascular Health Using Transcranial Doppler Ultrasound

2020 ◽  
Author(s):  
R. Ghorbani Afkhami ◽  
R. Wong ◽  
S. Ramadan ◽  
F. R. Walker ◽  
S. J. Johnson
Keyword(s):  
Blood Flow ◽  
Transcranial Doppler ◽  
Pulsatility Index ◽  
Augmentation Index ◽  
Transcranial Doppler Ultrasound ◽  
Cost Effective ◽  
Blood Flow Dynamics ◽  
Vascular Stiffening ◽  
Cerebrovascular Health ◽  
Magnetic Resonance Imaging Mri

AbstractTranscranial Doppler (TCD) blood flow velocity has been extensively used in biomedical research as it provides a cost-effective and relatively simple approach to assess changes in cerebral blood flow dynamics and track cerebrovascular health status. In this paper, we introduce a new TCD based timing index, TITCD, as an indicator of vascular stiffening and vascular health. We use two different datasets, D1 and D2 with 38 and 55 subjects, respectively to investigate the correlations of the new index and the existing indices, namely the pulsatility index (PITCD) and the augmentation index (AITCD), with age, cardiorespiratory fitness (CRF) and magnetic resonance imaging (MRI) blood flow pulsatility index (PIMRI). Comparing the correlation results, AITCD and TITCD both showed strong correlations with age (rD1 = 0.71, rD2 = 0.58 and rD1 = 0.69, rD2 = 0.50 respectively). While, PITCD had a significant correlation with age only in one of the datasets (rD2 = 0.41). The new TITCD index also showed better correlations with CRF (rD1 = −0.77) and PIMRI (rD1 = 0.50) compared to AITCD (rD1 = − 0.65 and rD1 = 0.33, respectively) and PITCD (no significant correlations with CRF or PIMRI). The proposed index has a much clearer relationship with vascular aging factors such as stiffness and cerebrovascular resistance (CVR) and therefore had the strongest correlations with CRF.

Cluster Headache: Transcranial Doppler Ultrasound and rCBF Studies

Cephalalgia ◽  
1990 ◽  
Vol 10 (2) ◽  
pp. 87-94 ◽  
Author(s):  
Arve Dahl ◽  
David Russell ◽  
Rolf Nyberg-Hansen ◽  
Kjell Rootwelt
Keyword(s):  
Blood Flow ◽  
Cluster Headache ◽  
Glyceryl Trinitrate ◽  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Transcranial Doppler ◽  
Statistical Significance ◽  
Transcranial Doppler Ultrasound ◽  
Normal Limits ◽  
Symptomatic Side

Transcranial Doppler and rCBF examinations were carried out in 25 cluster headache patients. Spontaneous and glyceryl trinitrate (nitroglycerin) provoked attacks were accompanied by a bilateral decrease in middle cerebral artery blood flow velocities. This decrease was more pronounced on the symptomatic side but the difference did not reach statistical significance. Mean hemispheric blood flow and rCBF were within normal limits during provoked attacks and similar to those found when patients were attack-free. During cluster periods middle cerebral artery velocities were significantly higher on the symptomatic side. Glyceryl trinitrate caused a bilateral middle cerebral artery velocity decrease which was significantly greater on the symptomatic side. Attacks provoked by glyceryl trinitrate appeared to begin when the vasodilatory effect of this substance was receding.

Transcranial Doppler Pulsatility Index: Not an Accurate Method to Assess Intracranial Pressure

Neurosurgery ◽  
2010 ◽  
Vol 66 (6) ◽  
pp. 1050-1057 ◽  
Author(s):  
Anders Behrens ◽  
Niklas Lenfeldt ◽  
Khalid Ambarki ◽  
Jan Malm ◽  
Anders Eklund ◽  
...  
Keyword(s):  
Blood Flow ◽  
Intracranial Pressure ◽  
Flow Velocity ◽  
Transcranial Doppler ◽  
Blood Flow Velocity ◽  
Pulsatility Index ◽  
Transcranial Doppler Sonography ◽  
Accurate Method ◽  
Mathematical Simulations

Abstract BACKGROUND Transcranial Doppler sonography (TCD) assessment of intracranial blood flow velocity has been suggested to accurately determine intracranial pressure (ICP). OBJECTIVE We attempted to validate this method in patients with communicating cerebrospinal fluid systems using predetermined pressure levels. METHODS Ten patients underwent a lumbar infusion test, applying 4 to 5 preset ICP levels. On each level, the pulsatility index (PI) in the middle cerebral artery was determined by measuring the blood flow velocity using TCD. ICP was simultaneously measured with an intraparenchymal sensor. ICP and PI were compared using correlation analysis. For further understanding of the ICP-PI relationship, a mathematical model of the intracranial dynamics was simulated using a computer. RESULTS The ICP-PI regression equation was based on data from 8 patients. For 2 patients, no audible Doppler signal was obtained. The equation was ICP = 23*PI + 14 (R2 = 0.22, P < .01, N = 35). The 95% confidence interval for a mean ICP of 20 mm Hg was −3.8 to 43.8 mm Hg. Individually, the regression coefficients varied from 42 to 90 and the offsets from −32 to +3. The mathematical simulations suggest that variations in vessel compliance, autoregulation, and arterial pressure have a serious effect on the ICP-PI relationship. CONCLUSIONS The in vivo results show that PI is not a reliable predictor of ICP. Mathematical simulations indicate that this is caused by variations in physiological parameters.

Transcranial Doppler Ultrasonic Features in Chronic Tension-Type Headache

Cephalalgia ◽  
1992 ◽  
Vol 12 (6) ◽  
pp. 385-386 ◽  
Author(s):  
Thomas-Martin Wallasch
Keyword(s):  
Blood Flow ◽  
Transcranial Doppler ◽  
Internal Carotid ◽  
Cerebral Arteries ◽  
Transcranial Doppler Ultrasound ◽  
Tension Type Headache ◽  
Chronic Tension Type Headache ◽  
Blood Flow Velocities ◽  
Type Headache ◽  
Flow Velocities

We studied vascular features in patients suffering from chronic headache of the tension-type by means of transcranial Doppler ultrasound (TCD). Blood flow velocities of the basal cerebral arteries and the submandibular extracranial part of the internal carotid artery were compared between 20 chronic tension-type headache sufferers and the same number of age- and sex-matched control subjects. There were no significant differences of ultrasonic features between the groups. Changes in blood flow velocities do not seem to be involved in the pathogenetic mechanisms of chronic tension-type headache.

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