scholarly journals Genome-wide association study of school grades identifies a genetic overlap between language ability, psychopathology and creativity

2020 ◽  
Author(s):  
Veera M. Rajagopal ◽  
Andrea Ganna ◽  
Jonathan R. I. Coleman ◽  
Andrea G. Allegrini ◽  
Georgios Voloudakis ◽  
...  
Keyword(s):  
Association Study ◽  
Psychiatric Disorders ◽  
Genome Wide Association Study ◽  
Language Ability ◽  
Math Performance ◽  
Genome Wide Association ◽  
Language Performance ◽  
School Grades ◽  
Genome Wide ◽  
A Genome

AbstractIndividuals with psychiatric disorders perform differently in school compared to the general population. Genetic factors contribute substantially to such differences. It is however unclear if differential performance is seen across all cognitive domains such as math and language. Here we report a genome-wide association study (GWAS) of school grades in 30,982 individuals (18,495 with and 12,487 without one or more of six major psychiatric disorders) and a replication study in 4,547 individuals. GWAS of overall school performance yielded results that were highly similar to the results of a previous GWAS of educational attainment. Analyzing subject specific grades, we observed that math performance was severely affected whereas language performance (Danish and English) was relatively unaffected or enhanced in those with psychiatric disorders compared to controls. We found that the genetic variants associated with poor math performance, but better language performance were also associated with increased risk for multiple psychiatric disorders. The same variants were also associated with creativity, which we show through a polygenic score analysis of 2953 creative professionals and 164,622 controls. The results overall suggest that risk for psychiatric disorders, language ability and creativity might have overlapping genetic roots.

scholarly journals A genome-wide association study of total child psychiatric problems scores

2020 ◽  
Author(s):  
Alexander Neumann ◽  
Ilja M. Nolte ◽  
Irene Pappa ◽  
Tarunveer S. Ahluwalia ◽  
Erik Pettersson ◽  
...  
Keyword(s):  
Association Study ◽  
Psychiatric Disorders ◽  
Genetic Variants ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Psychiatric Problem ◽  
Problem Score ◽  
Genome Wide ◽  
A Genome ◽  
Psychiatric Problems

ABSTRACTSubstantial genetic correlations have been reported across psychiatric disorders and numerous cross-disorder genetic variants have been detected. To identify the genetic variants underlying general psychopathology in childhood, we performed a genome-wide association study using a total psychiatric problem score. We analyzed 6,844,199 common SNPs in 38,418 school-aged children from 20 population-based cohorts participating in the EArly Genetics and Lifecourse Epidemiology (EAGLE) consortium. The SNP heritability of total psychiatric problems was 5.4% (SE=0.01) and two loci reached genome-wide significance: rs10767094 and rs202005905. We also observed an association of SBF2, a gene associated with neuroticism in previous GWAS, with total psychiatric problems. The genetic effects underlying the total psychiatric problem score were shared with known genetic variants for common psychiatric disorders only (attention-deficit/hyperactivity disorder, anxiety, depression, insomnia) (rG > 0.49), but not with autism or the less common adult disorders (schizophrenia, bipolar disorder, or eating disorders) (rG < 0.01). Importantly, the total psychiatric problem score also showed at least a moderate genetic correlation of with intelligence, educational attainment, wellbeing, smoking, and body fat (rG > 0.29).The results suggest that many common genetic variants are associated with childhood psychiatric symptoms and related phenotypes in general instead of with specific symptoms. Further research is needed to establish causality and pleiotropic mechanisms between psychiatric disorders and related traits.

scholarly journals 75. A GENOME-WIDE ASSOCIATION STUDY ACROSS PSYCHIATRIC DISORDERS IN THE EXPANDED IPSYCH2015 CASE-COHORT STUDY

2021 ◽  
Vol 51 ◽  
pp. e81
Author(s):  
John Shorter ◽  
Joeri Meijsen ◽  
Vivek Appadurai ◽  
Anders Rosengren ◽  
kajsa Georgii Hellberg ◽  
...  
Keyword(s):  
Cohort Study ◽  
Association Study ◽  
Psychiatric Disorders ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

scholarly journals A genome-wide association study for shared risk across major psychiatric disorders in a nation-wide birth cohort implicates fetal neurodevelopment as a key mediator

2017 ◽  
Author(s):  
Andrew J. Schork ◽  
Hyejung Won ◽  
Vivek Appadurai ◽  
Ron Nudel ◽  
Mike Gandal ◽  
...  
Keyword(s):  
Association Study ◽  
Psychiatric Disorders ◽  
Genome Wide Association Study ◽  
Radial Glia ◽  
Genome Wide Association ◽  
Genome Wide ◽  
Common Genetic Variants ◽  
A Genome ◽  
Nationally Representative ◽  
Shared Risk

AbstractThere is mounting evidence that seemingly diverse psychiatric disorders share genetic etiology, but the biological substrates mediating this overlap are not well characterized. Here, we leverage the unique iPSYCH study, a nationally representative cohort ascertained through clinical psychiatric diagnoses indicated in Danish national health registers. We confirm previous reports of individual and cross-disorder SNP-heritability for major psychiatric disorders and perform a cross-disorder genome-wide association study. We identify four novel genome-wide significant loci encompassing variants predicted to regulate genes expressed in radial glia and interneurons in the developing neocortex during midgestation. This epoch is supported by partitioning cross-disorder SNP-heritability which is enriched at regulatory chromatin active during fetal neurodevelopment. These findings indicate that dysregulation of genes that direct neurodevelopment by common genetic variants results in general liability for many later psychiatric outcomes.

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