scholarly journals 75. A GENOME-WIDE ASSOCIATION STUDY ACROSS PSYCHIATRIC DISORDERS IN THE EXPANDED IPSYCH2015 CASE-COHORT STUDY

2021 ◽  
Vol 51 ◽  
pp. e81
Author(s):  
John Shorter ◽  
Joeri Meijsen ◽  
Vivek Appadurai ◽  
Anders Rosengren ◽  
kajsa Georgii Hellberg ◽  
...  
Keyword(s):  
Cohort Study ◽  
Association Study ◽  
Psychiatric Disorders ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

scholarly journals A genome-wide association study of total child psychiatric problems scores

2020 ◽  
Author(s):  
Alexander Neumann ◽  
Ilja M. Nolte ◽  
Irene Pappa ◽  
Tarunveer S. Ahluwalia ◽  
Erik Pettersson ◽  
...  
Keyword(s):  
Association Study ◽  
Psychiatric Disorders ◽  
Genetic Variants ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Psychiatric Problem ◽  
Problem Score ◽  
Genome Wide ◽  
A Genome ◽  
Psychiatric Problems

ABSTRACTSubstantial genetic correlations have been reported across psychiatric disorders and numerous cross-disorder genetic variants have been detected. To identify the genetic variants underlying general psychopathology in childhood, we performed a genome-wide association study using a total psychiatric problem score. We analyzed 6,844,199 common SNPs in 38,418 school-aged children from 20 population-based cohorts participating in the EArly Genetics and Lifecourse Epidemiology (EAGLE) consortium. The SNP heritability of total psychiatric problems was 5.4% (SE=0.01) and two loci reached genome-wide significance: rs10767094 and rs202005905. We also observed an association of SBF2, a gene associated with neuroticism in previous GWAS, with total psychiatric problems. The genetic effects underlying the total psychiatric problem score were shared with known genetic variants for common psychiatric disorders only (attention-deficit/hyperactivity disorder, anxiety, depression, insomnia) (rG > 0.49), but not with autism or the less common adult disorders (schizophrenia, bipolar disorder, or eating disorders) (rG < 0.01). Importantly, the total psychiatric problem score also showed at least a moderate genetic correlation of with intelligence, educational attainment, wellbeing, smoking, and body fat (rG > 0.29).The results suggest that many common genetic variants are associated with childhood psychiatric symptoms and related phenotypes in general instead of with specific symptoms. Further research is needed to establish causality and pleiotropic mechanisms between psychiatric disorders and related traits.

scholarly journals Genome-wide association study of school grades identifies a genetic overlap between language ability, psychopathology and creativity

2020 ◽  
Author(s):  
Veera M. Rajagopal ◽  
Andrea Ganna ◽  
Jonathan R. I. Coleman ◽  
Andrea G. Allegrini ◽  
Georgios Voloudakis ◽  
...  
Keyword(s):  
Association Study ◽  
Psychiatric Disorders ◽  
Genome Wide Association Study ◽  
Language Ability ◽  
Math Performance ◽  
Genome Wide Association ◽  
Language Performance ◽  
School Grades ◽  
Genome Wide ◽  
A Genome

AbstractIndividuals with psychiatric disorders perform differently in school compared to the general population. Genetic factors contribute substantially to such differences. It is however unclear if differential performance is seen across all cognitive domains such as math and language. Here we report a genome-wide association study (GWAS) of school grades in 30,982 individuals (18,495 with and 12,487 without one or more of six major psychiatric disorders) and a replication study in 4,547 individuals. GWAS of overall school performance yielded results that were highly similar to the results of a previous GWAS of educational attainment. Analyzing subject specific grades, we observed that math performance was severely affected whereas language performance (Danish and English) was relatively unaffected or enhanced in those with psychiatric disorders compared to controls. We found that the genetic variants associated with poor math performance, but better language performance were also associated with increased risk for multiple psychiatric disorders. The same variants were also associated with creativity, which we show through a polygenic score analysis of 2953 creative professionals and 164,622 controls. The results overall suggest that risk for psychiatric disorders, language ability and creativity might have overlapping genetic roots.

A Genome-wide Association Study on Confection Consumption in a Japanese Population- The Japan Multi-Institutional Collaborative Cohort study

2021 ◽  
pp. 1-37
Author(s):  
Taro Suzuki ◽  
Yasuyuki Nakamura ◽  
Yukio Doi ◽  
Akira Narita ◽  
Atsushi Shimizu ◽  
...  
Keyword(s):  
Cohort Study ◽  
Association Study ◽  
Japanese Population ◽  
Alcohol Intake ◽  
Genome Wide Association Study ◽  
Sweet Taste ◽  
Taste Perception ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

Abstract Differences in individual eating habits may be influenced by genetic factors, in addition to cultural, social, or environmental factors. Previous studies suggested that genetic variants within sweet taste receptor genes family were associated with sweet taste perception and the intake of sweet foods. The aim of this study was to conduct a genome-wide association study (GWAS) to find genetic variations that affect confection consumption in a Japanese population. We analyzed GWAS data on sweets consumption using 14,073 participants from the Japan Multi-Institutional Collaborative Cohort study. We used a semi-quantitative food frequency questionnaire to estimate food intake that was validated previously. Association of the imputed variants with sweets consumption was performed by linear regression analysis with adjustments for age, sex, total energy intake and principal component analysis components 1 to 3. Furthermore, the analysis was repeated adjusting for alcohol intake (g/day) in addition to the above-described variables. We found 418 single nucleotide polymorphisms (SNPs) located in 12q24 that were associated with sweets consumption. SNPs with the 10 lowest P-values were located on nine genes including at the BRAP, ACAD10, and ALDH2 regions on 12q24.12-13. After adjustment for alcohol intake, no variant was associated with sweets intake with genome-wide significance. In conclusion, we found a significant number of SNPs located on 12q24 genes that were associated with sweets intake before adjustment for alcohol intake. However, all of them lost statistical significance after adjustment for alcohol intake.

scholarly journals A genome-wide association study for shared risk across major psychiatric disorders in a nation-wide birth cohort implicates fetal neurodevelopment as a key mediator

2017 ◽  
Author(s):  
Andrew J. Schork ◽  
Hyejung Won ◽  
Vivek Appadurai ◽  
Ron Nudel ◽  
Mike Gandal ◽  
...  
Keyword(s):  
Association Study ◽  
Psychiatric Disorders ◽  
Genome Wide Association Study ◽  
Radial Glia ◽  
Genome Wide Association ◽  
Genome Wide ◽  
Common Genetic Variants ◽  
A Genome ◽  
Nationally Representative ◽  
Shared Risk

AbstractThere is mounting evidence that seemingly diverse psychiatric disorders share genetic etiology, but the biological substrates mediating this overlap are not well characterized. Here, we leverage the unique iPSYCH study, a nationally representative cohort ascertained through clinical psychiatric diagnoses indicated in Danish national health registers. We confirm previous reports of individual and cross-disorder SNP-heritability for major psychiatric disorders and perform a cross-disorder genome-wide association study. We identify four novel genome-wide significant loci encompassing variants predicted to regulate genes expressed in radial glia and interneurons in the developing neocortex during midgestation. This epoch is supported by partitioning cross-disorder SNP-heritability which is enriched at regulatory chromatin active during fetal neurodevelopment. These findings indicate that dysregulation of genes that direct neurodevelopment by common genetic variants results in general liability for many later psychiatric outcomes.

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