scholarly journals Decreased homotopic interhemispheric functional connectivity in children with autism spectrum disorder

2020 ◽  
Author(s):  
Shuxia Yao ◽  
Menghan Zhou ◽  
Yuan Zhang ◽  
Feng Zhou ◽  
Qianqian Zhang ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Functional Connectivity ◽  
Symptom Severity ◽  
Visual Processing ◽  
Brain Networks ◽  
Cingulate Cortex ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Volume Changes ◽  
Processing Network

AbstractWhile a number of functional and structural changes occur in large-scale brain networks in autism spectrum disorder (ASD), reduced interhemispheric resting state functional connectivity (rsFC) between homotopic regions may be of particular importance as a biomarker. ASD is an early-onset developmental disorder and neural alterations are often age-dependent, reflecting dysregulated developmental trajectories, although no studies have investigated whether homotopic interhemispheric rsFC alterations occur in ASD children. The present study conducted a voxel-based homotopic interhemispheric rsFC analysis in 146 SD and 175 typically developing children under age 10 and examined associations with symptom severity in the Autism Brain Imaging Data Exchange datasets. Given the role of corpus callosum (CC) in interhemispheric connectivity and reported CC volume changes in ASD we additionally examined whether there were parallel volumetric changes in ASD children. Results demonstrated decreased homotopic rsFC in ASD children in the medial prefrontal cortex, precuneus and posterior cingulate cortex of the default mode network (DMN), the dorsal anterior cingulate cortex of the salience network, the precentral gyrus and inferior parietal lobule of the mirror neuron system, the lingual, fusiform and inferior occipital gyri of the visual processing network and thalamus. Symptom severity was associated with homotopic rsFC in regions in the DMN and visual processing network. There were no significant CC volume changes in ASD children. The present study shows that reduced homotopic interhemispheric rsFC in brain networks in ASD adults/adolescents is already present in children of 5-10 years old and further supports their potential use as a general ASD biomarker.

scholarly journals Atypical Resting-State Functional Connectivity of Intra/Inter-Sensory Networks Is Related to Symptom Severity in Young Boys With Autism Spectrum Disorder

2021 ◽  
Vol 12 ◽  
Author(s):  
Jia Wang ◽  
Xiaomin Wang ◽  
Runshi Wang ◽  
Xujun Duan ◽  
Heng Chen ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Functional Connectivity ◽  
Resting State ◽  
Symptom Severity ◽  
Interaction Strength ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Resting State Functional Connectivity ◽  
Connectivity Patterns ◽  
Visual Network

Autism spectrum disorder (ASD) has been reported to have altered brain connectivity patterns in sensory networks, assessed using resting-state functional magnetic imaging (rs-fMRI). However, the results have been inconsistent. Herein, we aimed to systematically explore the interaction between brain sensory networks in 3–7-year-old boys with ASD (N = 29) using independent component analysis (ICA). Participants were matched for age, head motion, and handedness in the MRI scanner. We estimated the between-group differences in spatial patterns of the sensory resting-state networks (RSNs). Subsequently, the time series of each RSN were extracted from each participant’s preprocessed data and associated estimates of interaction strength between intra- and internetwork functional connectivity (FC) and symptom severity in children with ASD. The auditory network (AN), higher visual network (HVN), primary visual network (PVN), and sensorimotor network (SMN) were identified. Relative to TDs, individuals with ASD showed increased FC in the AN and SMN, respectively. Higher positive connectivity between the PVN and HVN in the ASD group was shown. The strength of such connections was associated with symptom severity. The current study might suggest that the abnormal connectivity patterns of the sensory network regions may underlie impaired higher-order multisensory integration in ASD children, and be associated with social impairments.

scholarly journals Atypical flexibility in dynamic functional connectivity quantifies the severity in autism spectrum disorder

2018 ◽  
Author(s):  
Vatika Harlalka ◽  
Raju S. Bapi ◽  
P.K. Vinod ◽  
Dipanjan Roy
Keyword(s):  
Autism Spectrum Disorder ◽  
Functional Connectivity ◽  
Resting State ◽  
Symptom Severity ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Modular Organization ◽  
Strong Positive Correlation ◽  
Connection Strength ◽  
Whole Brain

AbstractResting-state functional connectivity (FC) analyses have shown atypical connectivity in autism spectrum disorder (ASD) as compared to typically developing (TD). However, this view emerges from investigating static FC overlooking the age, disease phenotype and their interaction in the whole brain transient connectivity patterns. Contrasting with most extant literature in the present study, we investigated precisely how age and disease phenotypes factors into dynamic changes in functional connectivity of TD and ASD using resting-state functional magnetic resonance imaging (rs-fMRI) data stratified into three cohorts: children (7–11 years) and adolescents (12–17 years), and adults (18+) for the analysis. The dynamic variability in the connection strength and the modular organization in terms of measures: flexibility, cohesion strength and disjointness were explored for each subject to characterize the differences between ASD and TD.In ASD, we observed significantly higher inter-subject dynamic variability in connection strength as compared to TD. This hypervariability relates to the symptom severity in ASD. We found that whole-brain flexibility correlates with static modularity only in TD. Further, we observed a core-periphery organization in the resting-state, with Sensorimotor and Visual regions in the rigid core; and DMN and attention areas in the flexible periphery. TD also develops a more cohesive organization of sensorimotor areas. However, in ASD we found a strong positive correlation of symptom severity with the flexibility of rigid areas and with disjointness of sensorimotor areas. The regions of the brain showing the high predictive power of symptom severity were distributed across the cortex, with stronger bearings in the frontal, motor and occipital cortices. Our study demonstrates that the dynamic framework best characterizes the variability in ASD.

scholarly journals Atypical Resting-State Functional Connectivity of Intra/Inter-Sensory Networks is Related to Symptom Severity in Young Boys with Autism Spectrum Disorder

2020 ◽  
Author(s):  
Jia Wang ◽  
Xiaomin Wang ◽  
Runshi Wang ◽  
Xujun Duan ◽  
Heng Chen ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Functional Connectivity ◽  
Resting State ◽  
Symptom Severity ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Social Impairment ◽  
Connectivity Pattern ◽  
Children With Asd ◽  
Visual Network

Abstract Background Autism spectrum disorder (ASD), a neurodevelopmental disorder, has been reported with an altered brain connectivity pattern in the sensory network using resting-state functional magnetic imaging (rs-fMRI) compared to typical developing participants (TDs). However, there is still no consistent conclusion. In the current study, we investigated the alterations of the intra-network and inter-network connectivity pattern relating to sensory in children with ASD compared with TDs, and further assessed whether these alterations are associated with autistic behavioral symptoms. Methods rs-fMRI was used to assess young boys with ASD (N=29) and TD (N=29), aged 3-7-years. Groups were matched for age and handiness. Spatial patterns of the sensory rest state networks (RSNs) were obtained using group Independent component analysis (ICA) method, and between-groups differences were evaluated within each sensory network. Then, the time series of each RSN were extracted from each participant preprocessed data. Correlation analysis was assessed among intra- and inter-network functional connectivity (FC) and symptom severity in children with ASD. Results Four sensory components were identified, including auditory network (AN), higher visual network (HVN), primary visual network (PVN) and sensorimotor network (SMN). Functional images revealed two sensory networks exhibiting significant increased FCs in ASD group, located within AN and SMN. Higher positive connectivity between PVN and HVN in ASD group is associated with symptom severity. Conclusion Current study might shed light that the abnormal connectivity patterns of sensory network regions may underlie impaired higher-order multisensory integration in ASD children, and social impairment of ASD are caused probably by aberrant FCs involving inter/intra- sensory network.

scholarly journals Increased Functional Connectivity Between Subcortical and Cortical Resting-State Networks in Autism Spectrum Disorder

2015 ◽  
Vol 72 (8) ◽  
pp. 767 ◽  
Author(s):  
Leonardo Cerliani ◽  
Maarten Mennes ◽  
Rajat M. Thomas ◽  
Adriana Di Martino ◽  
Marc Thioux ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Functional Connectivity ◽  
Resting State ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Resting State Networks
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