scholarly journals Comparative efficacy and safety of current drugs against COVID-19: A systematic review and network meta-analysis

2020 ◽  
Author(s):  
Yi Li ◽  
Wei He
Keyword(s):  
Systematic Review ◽  
Clinical Evidence ◽  
Meta Analysis ◽  
Clinical Decision ◽  
Added Value ◽  
Efficacy And Safety ◽  
Outcome Indicators ◽  
Rapid Spread ◽  
The World ◽  
Significant Health

AbstractThe rapid spread of coronavirus disease (COVID-19) has greatly disrupted the livelihood of many people around the world. To date, more than 35.16 million COVID-19 cases with 1.037million total deaths have been reported worldwide. Compared with China, where the disease was first reported, cases of COVID-19, the number of confirmed cases for the disease in the rest of the world have been incredibly high. Even though several dugs have been suggested to be used against the disease, the said interventions should be backed by empirical clinical evidence. Therefore, this paper provides a systematic review and a meta-analysis of efficacy and safety of different COVID-19 drugs.Research in contextEvidence before this studyCurrently, Covid-19 is one of the most urgent and significant health challenge, globally. However, so far there is no specific and effective treatment strategy against the disease. Nonetheless, there are numerous debates over the effectiveness and potential adverse effects of different COVID-19 antivirals. In general, there is invaluable need to continually report on new advances and successes against COVID-19, apparently to aid in managing the pandemic.Added value of this studyThis study provides a comprehensive, evidence-based guide on the management of multiple COVID-19 symptoms. In particular, we provide a review of 14 drugs, placebos and standard treatments against COVID 19. Meanwhile, we also performed a meta-analysis based on four clinical outcome indicators, to measure and compare the efficacy and safety of current interventions.Implications of all the available evidenceFindings of this research will guide clinical decision in COVID-19 patients. It will also provide a basis for predicting clinical outcomes such as efficacy, mortality and safety of interventions against the disease.

scholarly journals The efficacy and safety of interferons for the treatment of patients with COVID-19: protocol for systematic review and meta-analysis of controlled trials

2021 ◽  
Author(s):  
Afsaneh Noormandi ◽  
Mohammad Fathalipour ◽  
Reza Daryabeygi-Khotbehsara ◽  
Soheil Hassanipour
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Meta Analysis ◽  
World Health ◽  
Controlled Trials ◽  
Efficacy And Safety ◽  
Global Pandemic ◽  
The World ◽  
Health Organization ◽  
Time Of Administration

Background and objective: COVID-19 has since been declared a global pandemic by the World Health Organization (WHO), infecting millions worldwide. The use of Interferon (INF) subtypes previously examined in the treatment of SARS and MERS is also being initiated in some clinical trials. Although different clinical trials were evaluated IFNs in the treatment of COVID-19, their efficacy and safety remain unknown. Therefore, this study aims to systematically assess IFNs efficacy and safety in treating patients with COVID-19. Methods: The protocol has been registered in the PROSPERO International Prospective Register (CRD42020200643) on 24 July 2020. This protocol has been arranged according to the PRISMA-P (Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols) 2015 checklist. Discussion: Due to lack of approved medication for the covid-19 treatment and also various mutations of this virus, evaluated the efficacy and safety of medications by various studies could help for finding treatments with high effectiveness. IFNs are one of the medications that have been administered in covid-19 infection.  Moreover, the best time of administration and dose of this medication was unknown. Although meta-analysis is a potent source for assessing the accuracy of subjects, heterogeneity of articles is a potent limitation of our work.

scholarly journals Comparative Efficacy and Safety of the Moxibustion for the Treatment of Coronavirus Disease 2019 (COVID-19): Protocol for a Systematic Review and Meta-analysis.

2021 ◽  
Author(s):  
Juan Gao ◽  
Xiujuan Zhou ◽  
Hongyan Xie ◽  
hong Gao ◽  
xiaoxu Fu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Symptoms ◽  
Meta Analysis ◽  
Efficacy And Safety ◽  
Eligibility Criteria ◽  
Manual Search ◽  
Acute Respiratory Insufficiency ◽  
The World ◽  
Complementary And Alternative

Abstract Background Coronavirus disease 2019 (COVID-19) has spread from its origins to the world and become a pandemic since late 2019. It predominantly damages the lungs and causes diffuse alveolar injury with edema, cellular fibroblasts and hyaline membrane formation, resulting in acute respiratory insufficiency, respiratory failure, sepsis, acute heart injury, heart failure and other severe complications. It is also reported that moxibustion can effectively modify the negative emotions and relieve the symptoms of chest distress and impaired appetite for the patient with COVID-19. The main objective of current research is to make an assessment for effectiveness and safety of the moxibustion as an important complementary and alternative therapeutic method for COVID-19.Methods and analysis Articles for the systematic literature will be located at the MEDLINE, OVID, EMBASE, CNKI, CBM, NTR, Chi CTR databases. With no restriction about language, manual search will be conducted for potential eligible articles as supplements. Any randomized controlled trials (RCTs) with any moxibustion interventions issued by the therapeutic regimen on all patients diagnosed with COVID-19 will be included. We will include the published studies with no restriction about language. All study records of the title and abstract identified by the search strategies will be directly imported and assessed based on the eligibility criteria. Risk of individual studies for the methodological quality of eligible RCTs will be assessed with the tool from the Cochrane Collaboration’s risk of bias tool.Discussion The purpose of this study is to conduct a systematic review and meta-analysis of the efficacy and safety of moxibustion as a complementary and alternative treatment for COVID-19.No studies have investigated whether moxibustion will relieve clinical symptoms and shorten the length of hospitalization time.To the best of our knowledge, this is the first systematic review and meta-analysis program designed to update the currently available evidence. Despite the fact of controversial views in using moxibustion, if this study confirms its efficacy and safety, it could provide a better guide for clinical practice around the world.Systematic review registrationPROSPERO CRD42020176572.

scholarly journals The Effect of Different Ventilation Modes on the Outcomes of Patients Infected with Coronavirus Disease 2019 (COVID-19): a Protocol of Systematic Review and Network Meta-Analysis

2020 ◽  
Author(s):  
Yihao Zhu ◽  
Fei Wang ◽  
Tao Zhu
Keyword(s):  
Systematic Review ◽  
Evaluation System ◽  
Meta Analysis ◽  
Specific Treatment ◽  
Systemic Review ◽  
Efficacy And Safety ◽  
Ventilation Strategy ◽  
Number Of Patients ◽  
The World ◽  
Ventilation Modes

Abstract Background: Coronavirus disease 2019 (COVID-19) outbreak has spread around the world, the high mortality rate and strong infectious cause surging global patients diagnosed patients and death while in response to the outbreak, a myriad of scientific research workers and researchers have made unremitting efforts, but effective treatments are still limited, even may say that there is no specific treatment. So a large number of patients with severe patients need treatment for respiratory support, in particular, based on various realistic factors, different way of ventilation is widely used in clinical, which kind of ventilation way is the best one of the most effective ventilation strategy is not clear, so we planned a network meta-analysis to evaluate different ventilation methods on new crown the efficacy and safety of patients, expect to find an optimal ventilation strategy.Methods and analysis: Two authors will independently search the electronic databases, preprints databases, Clinical Study Registration website and COVID-19 research related project database from December 1, 2019 to November 5, 2020. The primary outcomes are 1) All-cause mortality; 2) Transmission of COVID-19 to health care workers and other people; 3) Length of hospital stay; 4) Length of ICU stay. A systemic review and a network meta-analysis based on Bayesian framework will be performed to assess the effect of different ventilation modes on the outcomes of patients infected with COVID-19. The Grading of Recommendations Assessment, Development and Evaluation System (GRADE) will be used to evaluate the quality of evidence.Discussion: COVID-19 has spread around the world and become a global public health security problem. With limited treatment available, a large number of critically ill patients need ventilator support treatment, and the demand for ventilators has increased sharply. To our knowledge, this study will be the first systematic review and NMA to analyze the efficacy and safety of different ventilation modes in patients with COVID-19. This study expected to obtain the best choice of ventilation mode for COVID-19 patients based on high quality evidence. Ethics and dissemination: Ethical approval is not required owning to it is a literature-based study. The final conclusion will be disseminated through peer-reviewed publication. PROSPERO registration number: CRD42020219581

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