scholarly journals High false-positive rate of fluorodeoxyglucose positron emission tomography to detect lymph node metastasis in microinvasive cervical cancer after conization

2021 ◽  
Author(s):  
Kidong Kim ◽  
Hayeon Kim ◽  
Hwajung Lee ◽  
Keun Ho Lee ◽  
Banghyun Lee ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Fdg Pet ◽  
Emission Tomography ◽  
Fluorodeoxyglucose Positron Emission Tomography ◽  
Node Metastasis ◽  
Positron Emission ◽  
Detect Lymph Node Metastasis ◽  
Fluorodeoxyglucose Positron Emission

AbstractWe aimed to estimate the positive predictive value of fluorodeoxyglucose positron emission tomography (FDG PET) to detect lymph node metastasis in patients with microinvasive cervical cancer who recently underwent conization. We retrospectively collected data of patients fulfilling the following criteria: 1) cervical cancer stage 1A1 (by FIGO staging revised in 1994) without invasion of the lymphovascular space diagnosed by conization from September 2008 to July 2018, 2) FDG PET within 3 months after diagnosis, 3) lymph node metastasis suspected by FDG PET, and 4) histologic confirmation or follow-up imaging study for suspected lymph node metastasis. Lymph node metastasis was suspected in 31 regions in 18 patients; however, no true metastasis was found. In conclusion, lymph node metastasis suspected by FDG PET in microinvasive cervical cancer after conization might be false positive. Lymph node dissection should not be performed for such patients.

scholarly journals Comparison between18F-Fluorodeoxyglucose Positron Emission Tomography and Sentinel Lymph Node Biopsy for Regional Lymph Nodal Staging in Patients with Melanoma: A Review of the Literature

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Paoletta Mirk ◽  
Giorgio Treglia ◽  
Marco Salsano ◽  
Pietro Basile ◽  
Alessandro Giordano ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Lymph Node ◽  
Fdg Pet ◽  
Lymph Node Biopsy ◽  
Emission Tomography ◽  
Fluorodeoxyglucose Positron Emission Tomography ◽  
Nodal Staging ◽  
Node Biopsy ◽  
Positron Emission ◽  
Fluorodeoxyglucose Positron Emission

Aim. to compare18F-Fluorodeoxyglucose positron emission tomography (FDG-PET) to sentinel lymph node biopsy (SLNB) for regional lymph nodal staging in patients with melanoma.Methods. We performed a literature review discussing original articles which compared FDG-PET to SLNB for regional lymph nodal staging in patients with melanoma.Results and Conclusions. There is consensus in the literature that FDG-PET cannot replace SLNB for regional lymph nodal staging in patients with melanoma.

Histologic Results of Para-Aortic Lymphadenectomy in Patients Treated for Stage IB2/II Cervical Cancer With Negative [18F]Fluorodeoxyglucose Positron Emission Tomography Scans in the Para-Aortic Area

2008 ◽  
Vol 26 (15) ◽  
pp. 2558-2561 ◽  
Author(s):  
Mathias Boughanim ◽  
Sophie Leboulleux ◽  
Annie Rey ◽  
Chi Tuan Pham ◽  
Yaelle Zafrani ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Fdg Pet ◽  
Emission Tomography ◽  
Fluorodeoxyglucose Positron Emission Tomography ◽  
Nodal Involvement ◽  
Positron Emission ◽  
Pet Ct ◽  
Aortic Area ◽  
Fdg Pet Ct ◽  
Fluorodeoxyglucose Positron Emission

Purpose Histologic results of complete para-aortic lymphadenectomy were studied in patients treated for stage IB2/II cervical carcinoma who had no para-aortic uptake on [18F]fluorodeoxyglucose positron emission tomography combined with integrated computed tomography (FDG-PET/CT). Patients and Methods Patients were treated between 2004 and 2006 for stage IB2/II cervical cancer. Magnetic resonance imaging of the abdomen and pelvis and FDG-PET/CT were initially performed. Patients with no para-aortic abnormalities were treated with external pelvic radiation therapy and concomitant chemotherapy followed by utero-vaginal brachytherapy. Para-aortic lymphadenectomy was then performed. FDG-PET/CT images were reviewed by two nuclear medicine specialists. Results Thirty-eight patients were studied. Three patients had histologically proven para-aortic involvement (metastatic nodes with capsular rupture in the para-aortic area), leading to a negative predictive value of 92% for para-aortic nodal involvement. Conclusion In this study, three of 38 patients with no para-aortic uptake on [18F]FDG-PET/CT imaging had histologically proven para-aortic node involvement. PET/CT imaging without histologic examination of the para-aortic area used to determine radiation therapy fields in stage IB2/II cervical cancer would overlook 8% of patients with histologic para-aortic nodal involvement.

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