Class-Modeling of Septic Shock With Hyperdimensional Computing

Sepsis arises when a patient's immune system has an extreme reaction to an infection. This is followed by septic shock if damage to organ tissue is so extensive that it causes a total systemic failure. Early detection of septic shock among septic patients could save critical time for preparation and prevention treatment. Due to the high variance in symptoms and patient state before shock, it is challenging to create a protocol that would be effective across patients. However, since septic shock is an acute change in patient state, modeling patient stability could be more effective in detecting a condition that departs from it. In this paper we present a one-class classification approach to septic shock using hyperdimensional computing. We built various models that consider different contexts and can be adapted according to a target priority. Among septic patients, the models can detect septic shock accurately with 90% sensitivity and overall accuracy of 60% of the cases up to three hours before the onset of septic shock, with the ability to adjust predictions according to incoming data. Additionally, the models can be easily adapted to prioritize sensitivity (increase true positives) or specificity (decrease false positives).

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An One Class Classification Approach to Non-relevance Feedback Document Retrieval

Fuzzy Systems and Knowledge Discovery - Lecture Notes in Computer Science ◽

10.1007/11540007_161 ◽

2005 ◽

pp. 1216-1225

Author(s):

Takashi Onoda ◽

Hiroshi Murata ◽

Seiji Yamada

Keyword(s):

Relevance Feedback ◽

Document Retrieval ◽

Classification Approach ◽

One Class Classification

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Outliers analysis and one class classification approach for planetary gearbox diagnosis

Journal of Physics Conference Series ◽

10.1088/1742-6596/305/1/012031 ◽

2011 ◽

Vol 305 ◽

pp. 012031 ◽

Cited By ~ 13

Author(s):

Anna Bartkowiak ◽

Radoslaw Zimroz

Keyword(s):

Classification Approach ◽

Planetary Gearbox ◽

One Class Classification

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A novel one-class classification approach to accurately predict disease-gene association in acute myeloid leukemia cancer

PLoS ONE ◽

10.1371/journal.pone.0226115 ◽

2019 ◽

Vol 14 (12) ◽

pp. e0226115 ◽

Cited By ~ 1

Author(s):

Akram Vasighizaker ◽

Alok Sharma ◽

Abdollah Dehzangi

Keyword(s):

Acute Myeloid Leukemia ◽

Myeloid Leukemia ◽

Disease Gene ◽

Classification Approach ◽

Gene Association ◽

One Class Classification ◽

Acute Myeloid

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Immunoregulatory biological response modifiers: effect of cytokines on septic shock

Mediators of Inflammation ◽

10.1155/s0962935193000675 ◽

1993 ◽

Vol 2 (7) ◽

pp. S5-S10 ◽

Cited By ~ 4

Author(s):

Michael A. Chirigos ◽

Claudio De Simone

Keyword(s):

Septic Shock ◽

Immune System ◽

Tumour Necrosis Factor ◽

Tumour Necrosis ◽

Biological Response ◽

Therapeutic Benefit ◽

Biological Response Modifiers ◽

Beneficial Effects ◽

Cellular Components ◽

Necrosis Factor

Whole bacteria or bacterial components or their extracts were employed to restore or augment the immune system. Beneficial effects were attained with these agents in treating various diseases. These agents were named biological response modifiers (BRMs) because they regulated certain cellular components of the immune system. The cellular regulation induced by these BRMs was found to be due to cytokines. The cytokines were shown to act directly on the various cellular components and to provide therapeutic benefit in various autoimmune and immune deficiency diseases. Overproduction of specific cytokines however leads to a deleterious effect on the host. Overproduction of tumour necrosis factor (endotoxin, lipopolysaccharide) leads to septic shock. Bacteraemia is the leading cause of overproduction of tumour necrosis factor (TNF). Septic shock in many cases leads to death. Several monoclonal antibodies to lipopolysaccharide (LPS) and anticytokines have demonstrated protection against septic shock.

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Mapping raised bogs with an iterative one-class classification approach

ISPRS Journal of Photogrammetry and Remote Sensing ◽

10.1016/j.isprsjprs.2016.07.008 ◽

2016 ◽

Vol 120 ◽

pp. 53-64 ◽

Cited By ~ 24

Author(s):

Benjamin Mack ◽

Ribana Roscher ◽

Stefanie Stenzel ◽

Hannes Feilhauer ◽

Sebastian Schmidtlein ◽

...

Keyword(s):

Classification Approach ◽

Raised Bogs ◽

One Class Classification

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Corticosteroid in Septic Shock: Advantage or Disadvantage?

Majalah Sainstekes ◽

10.33476/ms.v6i2.1198 ◽

2019 ◽

Vol 6 (2) ◽

Author(s):

Sakura Muhammad Tola

Keyword(s):

Septic Shock ◽

Immune System ◽

Inflammatory Disease ◽

Adjunctive Therapy ◽

Innate Immune System ◽

Innate Immune ◽

Hemodynamic Stability ◽

Major Health ◽

Major Health Issue ◽

Multi Organ Dysfunction Syndrome

Sepsis has become a major health issue, with more patients dying in hospitals due to sepsis related complications. The pathogenesis of sepsis is complex and involves multiple aspects of the interaction between the infecting microorganisms and the host. Sepsis is fundamentally an inflammatory disease mediated by the activation of the innate immune system. In the case, sepsis is an unbalanced (proinflammatory and anti-inflammatory), dysregulated response, the localized process goes out of control and becomes systemic contribute to diminished oxygen delivery. The process also leads to decreased hemodynamic stability, hyperglycemia and ultimately, multi organ dysfunction syndrome and death in septic shock. The use of corticosteroid hydrocortisone as adjunctive therapy is still debating due to the lack of supporting study and differences result among the studies.

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diagnosis and trEatmEnt of patiEnts in sEptiC shoCK

New Medicine ◽

10.5604/01.3001.0009.7846 ◽

2017 ◽

Vol 21 (1) ◽

pp. 31-36

Author(s):

Jacek wadełek

Keyword(s):

Septic Shock ◽

Organ Dysfunction ◽

Host Response ◽

Signs And Symptoms ◽

Intravenous Fluids ◽

Failure Assessment ◽

Acute Change ◽

Life Threatening ◽

Sepsis And Septic Shock ◽

Clinical Emergency

sepsis and septic shock are a clinical emergency. sepsis is defined as a life-threatening organ dysfunction due to a dysregulated host response to infection, and organ dysfunction is defined as an acute change in sequential organ failure assessment (sofa) score greater than 2 points secondary to an infectious cause. septic shock is defined as sepsis with persisting hypotension requiring vasopressors to maintain a mean arterial pressure of 65 mm hg or higher, and blood lactate level greater than 2 mmol/l (18 mg/dl) despite adequate volume resuscitation. the diagnosis of septic shock begins with medical history and physical examination focused on the signs and symptoms of infection, with the aim of recognizing complex physiologic manifestations of shock. Clinicians should understand the importance of prompt administration of antibiotics, vasopressors and intravenous fluids aimed at restoring adequate circulation. they should also be aware of the limitations of the protocol-based therapy.

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