scholarly journals Extremely bright, near-IR emitting spontaneously blinking fluorophores enable ratiometric multicolor nanoscopy in live cells

2021 ◽  
Author(s):  
Jonathan Tyson ◽  
Kevin Hu ◽  
Shuai Zheng ◽  
Phylicia Kidd ◽  
Neville Dadina ◽  
...  
Keyword(s):  
Single Molecule ◽  
Biological Evaluation ◽  
Live Cell ◽  
Live Cells ◽  
Chemical Additives ◽  
Design Synthesis ◽  
Near Ir ◽  
Intracellular Organelles ◽  
Synthesis And Biological Evaluation ◽  
Single Molecule Localization Microscopy

New bright, photostable, emission-orthogonal fluorophores that blink without toxic additives are needed to enable multi-color, live-cell, single-molecule localization microscopy (SMLM), especially for experiments that demand ultra-high-resolution live imaging. Here we report the design, synthesis, and biological evaluation of Yale676sb, a photostable, near-IR emitting fluorophore that achieves these goals in the context of an exceptional quantum yield (0.59). When used alongside HMSiR, Yale676sb enables simultaneous, live-cell, two-color SMLM of two intracellular organelles (ER + mitochondria) with only a single laser and no chemical additives.

Design, synthesis and biological evaluation of novel pteridinone derivatives possessing a sulfonyl moiety as potent dual inhibitors of PLK1 and BRD4

2021 ◽  
Author(s):  
Fei Chen ◽  
Yu Wang ◽  
Zhanfeng Gao ◽  
Shihui Wang ◽  
Jiuyu Liu ◽  
...  
Keyword(s):  
Single Molecule ◽  
Therapeutic Strategy ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Effective Therapeutic Strategy ◽  
Dual Inhibitors ◽  
Simultaneous Inhibition ◽  
Synthesis And Biological Evaluation

The simultaneous inhibition of PLK1 and BRD4 by a single molecule could lead to the development of an effective therapeutic strategy for a variety of diseases in which PLK1 and...

Design, synthesis and biological evaluation of novel pteridinone derivatives as potent dual inhibitors of PLK1 and BRD4

2020 ◽  
Vol 44 (38) ◽  
pp. 16477-16490
Author(s):  
Yinliang Qi ◽  
Le Xu ◽  
Zhiwei Li ◽  
Ping Gong ◽  
Tao Hu ◽  
...  
Keyword(s):  
Biological Activity ◽  
Single Molecule ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Dual Inhibitors ◽  
Simultaneous Inhibition ◽  
Synthesis And Biological Evaluation

To develop novel simultaneous inhibition of PLK1 and BRD4 bromodomain by a single molecule, three series of novel pteridinone derivatives were designed, synthesized and evaluated for their biological activity.

Design, Synthesis and Biological Evaluation of Hybrid Molecules Containing Conjugated Styryl Ketone and α-Bromoacryloyl Moieties

2012 ◽  
Vol 9 (2) ◽  
pp. 140-152 ◽  
Author(s):  
Romeo Romagnoli ◽  
Pier Giovanni Baraldi ◽  
Olga Cruz-Lopez ◽  
Maria Kimatrai Salvador ◽  
Delia Preti ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Hybrid Molecules ◽  
Synthesis And Biological Evaluation

Design, Synthesis and Biological Evaluation of Novel Aminosaccharide Derivatives of Combretastatin A-4

2013 ◽  
Vol 10 (10) ◽  
pp. 935-941
Author(s):  
Yan Tang ◽  
Zhewei Tu ◽  
Jing Sun ◽  
Xiong Zhu ◽  
Kun Liu ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of

Design, Synthesis and Biological Evaluation of Benzopyran Derivatives as KATP Channel Openers

2010 ◽  
Vol 7 (6) ◽  
pp. 415-420 ◽  
Author(s):  
Jinpei Zhou ◽  
Hai Qian ◽  
Huibin Zhang ◽  
Hui Gao ◽  
Wenlong Huang ◽  
...  
Keyword(s):  
Katp Channel ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation ◽  
Katp Channel Openers
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