scholarly journals Orthogonal representation of task-related information in theta phase-based multiple place fields of single units in the subiculum

2021 ◽  
Author(s):  
Su-Min Lee ◽  
Jae-Min Seol ◽  
Inah Lee
Keyword(s):  
Theta Rhythm ◽  
Memory Task ◽  
Field Size ◽  
Male Rats ◽  
Choice Response ◽  
Neural Firing ◽  
Related Factors ◽  
Related Information ◽  
Phase Precession ◽  
Theta Phase

The subiculum is positioned at a critical juncture at the interface of the hippocampus with the rest of the brain. However, the exact roles of the subiculum in most hippocampal-dependent memory tasks remain largely unknown. One obstacle to make analytical comparisons of neural firing patterns between the subiculum and hippocampal CA1 is the broad firing fields of the subicular cells. Here, we used spiking phases in relation to theta rhythm to parse the broad firing field of a subicular neuron into multiple subfields to find the unique functional contribution of the subiculum while male rats performed a hippocampal-dependent visual scene memory task. Some of the broad firing fields of the subicular neurons were successfully divided into multiple subfields by using the theta-phase precession cycle. The resulting phase-based fields in the subiculum were more similar to those in CA1 in terms of the field size and phase-precession strength. The new method significantly improved the detection of task-relevant information in subicular cells without affecting the information content represented by CA1 cells. Notably, multiple fields of a single subicular neuron, unlike those in the CA1, could carry heterogeneous task-related information such as visual context and choice response. Our findings suggest that the subicular cells integrate multiple task-related factors by using theta rhythm to associate environmental context with action.

scholarly journals Coherent coding of spatial position mediated by theta oscillations in hippocampus and prefrontal cortex

2019 ◽  
Author(s):  
Mark C. Zielinski ◽  
Justin D. Shin ◽  
Shantanu P. Jadhav
Keyword(s):  
Prefrontal Cortex ◽  
Spatial Memory ◽  
Spatial Information ◽  
Cell Activity ◽  
Memory Task ◽  
Physiological Mechanism ◽  
Spatial Position ◽  
Theta Oscillations ◽  
Male Rats ◽  
Theta Phase

ABSTRACTInteractions between the hippocampus (area CA1) and prefrontal cortex (PFC) are crucial for memory-guided behavior. Theta oscillations (~8 Hz) underlie a key physiological mechanism for mediating these coordinated interactions, and theta oscillatory coherence and phase-locked spiking in the two regions have been shown to be important for spatial memory. Hippocampal place cell activity associated with theta oscillations encodes spatial position during behavior, and theta-phase associated spiking is known to further mediate a temporal code for space within CA1 place fields. Although prefrontal neurons are prominently phase-locked to hippocampal theta oscillations in spatial memory tasks, whether and how theta oscillations mediate processing of spatial information across these networks remains unclear. Here, we addressed these questions using simultaneous recordings of dorsal CA1 – PFC ensembles and population decoding analyses in male rats performing a continuous spatial working memory task known to require hippocampal-prefrontal interactions. We found that in addition to CA1, population activity in PFC can also encode the animal’s current spatial position on a theta-cycle timescale during memory-guided behavior. Coding of spatial position was coherent for CA1 and PFC ensembles, exhibiting correlated position representations within theta cycles. In addition, incorporating theta-phase information during decoding to account for theta-phase associated spiking resulted in a significant improvement in the accuracy of prefrontal spatial representations, similar to concurrent CA1 representations. These findings indicate a theta-oscillation mediated mechanism of temporal coordination for shared processing and communication of spatial information across the two networks during spatial memory-guided behavior.

scholarly journals Independent theta phase coding accounts for CA1 population sequences and enables flexible remapping

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Angus Chadwick ◽  
Mark CW van Rossum ◽  
Matthew F Nolan
Keyword(s):  
Traveling Wave ◽  
Action Potentials ◽  
Theta Rhythm ◽  
Place Cells ◽  
Population Activity ◽  
Phase Coding ◽  
Synaptic Interactions ◽  
Spike Sequences ◽  
Rate Coding ◽  
Theta Phase

Hippocampal place cells encode an animal's past, current, and future location through sequences of action potentials generated within each cycle of the network theta rhythm. These sequential representations have been suggested to result from temporally coordinated synaptic interactions within and between cell assemblies. Instead, we find through simulations and analysis of experimental data that rate and phase coding in independent neurons is sufficient to explain the organization of CA1 population activity during theta states. We show that CA1 population activity can be described as an evolving traveling wave that exhibits phase coding, rate coding, spike sequences and that generates an emergent population theta rhythm. We identify measures of global remapping and intracellular theta dynamics as critical for distinguishing mechanisms for pacemaking and coordination of sequential population activity. Our analysis suggests that, unlike synaptically coupled assemblies, independent neurons flexibly generate sequential population activity within the duration of a single theta cycle.

scholarly journals Smokers’ curiosity for tobacco-related trivia aids memory of tobacco-related information

2021 ◽  
Author(s):  
Jaydin Clark ◽  
Asia Vincent ◽  
Xinyi Wang ◽  
Amanda Lee McGowan ◽  
David M. Lydon-Staley
Keyword(s):  
Health Information ◽  
Memory Task ◽  
Related Information ◽  
Open Questions

Curiosity promotes learning. Two open questions concern the extent to which tobacco smokers exhibit curiosity about smoking-related health information and whether this curiosity can facilitate recall of this information. Participants (n=324 smokers; n=280 non-smokers) performed a Trivia Guessing Task wherein participants guessed the answers to general trivia and smoking-related trivia questions and provided ratings of their curiosity prior to viewing the answers to the questions. A subset of participants (n=121 smokers; n=97 non-smokers) completed a surprise Trivia Memory Task one-week later and answered the previously-viewed questions. Results indicate that smokers are no less curious about smoking-related trivia than they are about general trivia and that curiosity about the answer to smoking-related trivia is associated with more accurate recall of smoking-related trivia answers one week later. Findings suggest that engendering states of curiosity for smoking-related information may facilitate retention of that information in smokers.

A Framework for Ontology-Based Heterogeneous Data Integration for Cost Management in Product Family Design

2008 ◽  
Author(s):  
Xiaomeng Chang ◽  
Janis Terpenny
Keyword(s):  
Product Family ◽  
Heterogeneous Data ◽  
Schema Integration ◽  
Product Family Design ◽  
Related Factors ◽  
Product Families ◽  
Heterogeneous Data Integration ◽  
Related Information ◽  
Semantic Data ◽  
Data Schema

High quality, high impact and economical products and systems are important goals for an enterprise. The usage of product families can be strategic to achieving these goals, yet defining these families can be challenging, requiring the consideration of numerous cost factors. This requires bringing together a great number of heterogeneous data sources of varying formats in a manner that allows the product development team to easily locate and reuse information in a collaborative manner across time and space. To date, our work has focused on the development and use of an Activity-Based Cost ontology (ABC ontology) to guide designers drill down to get at information for product family design. However, this ontology is built in such a way that it can only support information retrieval from the ontology and does not bring together and connect heterogeneous data resources. It does not address the problem of designers who struggle with obtaining relevant details from different departments in an enterprise. While there have been several semantic data schema integration tools for heterogeneous data resources integration, these tools cannot guide users to related information, that would lead to the root cause of the high cost. In this paper, in order to better manage cost in product family design, an ontology-based framework is put forward that builds on our prior work and combines the advantages of ABC ontology and data schema integration tools. The ontology-based framework can guide users to the proper information aspects through querying the central ontology, and give users detailed information about these aspects from heterogeneous data resources with the support of local ontologies. Ultimately, this framework will facilitate designers with better utilization of cost-related factors for product family design from a whole enterprise perspective.

scholarly journals Theta phase precession beyond the hippocampus

2012 ◽  
Vol 23 (1) ◽  
Author(s):  
Sushant Malhotra ◽  
Robert W.A. Cross ◽  
Matthijs A.A. van der Meer
Keyword(s):  
Phase Precession ◽  
Theta Phase ◽  
Theta Phase Precession

scholarly journals Administration of a 20-Hydroxyeicosatetraenoic Acid Synthesis Inhibitor Improves Outcome in a Rat Model of Pediatric Traumatic Brain Injury

2019 ◽  
Vol 41 (3-4) ◽  
pp. 166-176 ◽  
Author(s):  
Shiyu Shu ◽  
Zhi Zhang ◽  
Dawn Spicer ◽  
Ewa Kulikowicz ◽  
Ke Hu ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Ischemia Reperfusion ◽  
Memory Task ◽  
Male Rats ◽  
Lesion Volume ◽  
Hydroxyeicosatetraenoic Acid ◽  
Post Injury ◽  
Synthesis Inhibitor ◽  
Tnf Α

The arachidonic acid pathway metabolite 20-hydroxyeicosatetraenoic acid (20-HETE) contributes to ischemia/reperfusion brain injury. Inhibition of 20-HETE formation can protect the developing brain from global ischemia. Here, we examined whether treatment with the 20-HETE synthesis inhibitor N-hydroxy-N-4-butyl-2-methylphenylformamidine (HET0016) can protect the immature brain from traumatic brain injury (TBI). Male rats at postnatal day 9–10 underwent controlled cortical impact followed by intraperitoneal injection with vehicle or HET0016 (1 mg/kg, 5 min and 3 h post-injury). HET0016 decreased the lesion volume by over 50% at 3 days of recovery, and this effect persisted at 30 days as the brain matured. HET0016 decreased peri-lesion gene expression of proinflammatory cytokines (tumor necrosis factor-α [TNF-α], interleukin-1β [IL-1β]) at 1 day and increased reparative cytokine (IL-4, IL-10) expression at 3 days. It also partially preserved microglial ramified processes, consistent with less activation. HET0016 decreased contralateral hindlimb foot faults and improved outcome on the novel object recognition memory task 30 days after TBI. In cultured BV2 microglia, HET0016 attenuated the lipopolysaccharide-evoked increase in release of TNF-α. Our data show that HET0016 improves acute and long-term histologic and functional outcomes, in association with an attenuated neuroinflammatory response after contusion of an immature rat brain.

Sign in / Sign up

Export Citation Format

Share Document