Knowledge-Based Decision Support for Concept Evaluation Using the Extended Impact Model of Modular Product Families

The design of modular product families enables a high external variety of products by a low internal variety of components and processes. This variety optimization leads to large economic savings along the entire value chain. However, when designing and selecting suitable modular product architecture concepts, often only direct costs are considered, and indirect costs as well as cross-cost center benefits are neglected. A lack of knowledge about the full savings potential often results in the selection of inferior solutions. Since available approaches do not adequately address this problem, this paper provides a new methodological support tool that ensures consideration of the full savings potentials in the evaluation of modular product architecture concepts. For this purpose, the visual knowledge base of the Impact Model of Modular Product Families (IMF) is used, extended and implemented in a model-based environment using SysML. The newly developed Sys-IMF is then applied to the product family example of electric medium-voltage motors. The support tool is dynamic, expandable and filterable and embedded in a methodical procedure for knowledge-based decision support. Sys-IMF supports decision makers in the early phase of interdisciplinary product development and enables the selection of the most suitable modular solution for the company.

Resource Modelling for the QC Laboratory at XYZ Pharmaceuticals in Southern Africa

Quality control (QC) laboratories are critical components in drug manufacturing and running them efficiently contributes to better, consistent supply of cost-effective quality products, while also and preventing deaths due to untimely delivery or unavailability of medicines. Having a resource modelling tool to estimate resources needed to handle a particular demand in a given system is essential for efficient running of QC laboratory. This study was done to establish such a model at XYZ Pharmaceuticals. The list of all products manufactured by XYZ Pharmaceuticals Southern Africa was reviewed; and product families for all products were identified. Analysts’ hands on time (HOT) to process one sample of each of the product families was estimated. The number of analysts required to support the workload at XYZ Pharmaceuticals was calculated using the HOTs for the different product families and the Maslaton’s Calculation Model. A baseline resource model was established.

New from old: discovery of the novel antibiotic actinomycin L in Streptomyces sp. MBT27

ABSTRACTStreptomycetes are major producers of bioactive natural products, including the majority of the antibiotics. While much if the low-hanging fruit has been discovered, it is predited that less than 5% of the chemical space has been mined. Here, we describe the novel actinomycins L1 and L2, which are produced by Streptomyces sp. MBT27. The molecules were discovered via metabolic analysis combined with molecular networking of cultures grown with different combinations of carbon sources. Actinomycins L1 and L2 are diastereoisomers, and the structure of actinomycin L2 was resolved using NMR and single crystal X-ray crystallography. Actinomycin L is formed via a unique spirolinkage of anthranilamide to the 4-oxoproline moiety of actinomycin X2, prior to the condensation of the actinomycin halves. Feeding anthranilamide to cultures of Streptomyces antibioticus, which has the same biosynthetic gene cluster as Streptomyces sp. MBT27 but only produces actinomycin X2, resulted in the production of actinomycin L. This shows that actinomycin L results from joining two distinct metabolic pathways, namely those for actinomycin X2 and for anthranilamide. Actinomycins L1 and L2 showed significant antimicrobial activity against Gram- positive bacteria. Our work shows how new molecules can still be identified even in the oldest of natural product families.IMPORTANCEActinomycin was the first antibiotic discovered in an actinobacterium by Selman Waksman and colleagues, as early as 1940. This period essentially marks the start of the ‘golden era’ of antibiotic discovery. Over time, emerging antimicrobial resistance (AMR) and the declining success rate of antibiotic discovery resulted in the current antibiotic crisis. We surprisingly discovered that under some growth conditions, Streptomyces sp. MBT27 can produce actinomycins that are significantly different from those that have been published so far. The impact of this work is not only that we have discovered a novel molecule with very interesting chemical modifications in one of the oldest antibiotics ever described, but also that this requires the combined action of primary and secondary metabolic pathways, namely the biosynthesis of anthranilamide and of actinomycin X2, respectively. The implication of the discovery is that even the most well-studied families of natural products may still have surprises in store for us.

Influence of different curing regimes on properties of new copolymer of chloroprene and acrylonitrile

The curing system plays a vital role in designing rubber compounds for various industrial applications. Therefore, it is paramount to establish viable curing strategies for any new elastomer to explore its application potentials and commercial significance. Impacts of different curing regimes on the properties of a recently developed copolymer of chloroprene and acrylonitrile (acrylonitrile-chloroprene rubber, NCR) are reported here. Several primary accelerators (four from thiourea- and one from thiazolene product families) were used for curing the new rubber along with fixed loadings of zinc oxide (5 phr) and magnesium oxide (4 phr). Besides, curatives based on sulfur and peroxide were also evaluated. The influence of different curing systems on the rheological and physical properties of the copolymer was explored. It has been seen that the properties of the copolymer are considerably influenced by the different curing systems used. While ethylene thiourea (ETU) and propylene thiourea (PTU), as primary accelerators, provide the highest state of cure but may cause scorch. The use of trimethyl thiourea (TMU), on the other hand, results in the fastest rate and the most stable state of cure, good scorch safety, bin stability, and an overall good balance of properties. The sulfur-based crosslinking system induces good mechanical properties but causes limited bin stability, poor high-temperature compression set, and impaired heat resistance properties. As a curing agent, peroxide delivers the best bin stability in the rubber stocks but yields higher stiffness and limited aging resistance in the vulcanizates.

EXTENDING PRODUCT FAMILY DESIGN METHODS TO PRODUCT-SERVICE-SYSTEM FAMILY DESIGN

Although product family design methods are well established, little research has focused on Product-Service-System (PSS) family design. A PSS family design method is proposed in this paper that parallels methodology for designing product families. Separate platforms are proposed for products and for services. However, couplings between product and service platforms are identified and incorporated into the design method. Design problem formulations are proposed for PSS family platforms and for the PSS family itself, using a module-based approach, in contrast to a platform scaling approach. Alternative methods are investigated and compared for solving these problems. The application domain of Assistive Mobility (AM) is identified as a promising PSS family in this work. If smart technologies are integrated into AM devices, such as manual wheelchairs, powered wheelchairs, walkers, and rollators, then patient diagnosis and treatment, as well as device maintenance, services are enabled with these smart technologies, demonstrating that smart AM devices are a promising PSS family.

INTRODUCING A FRAMEWORK TO GENERATE AND EVALUATE THE COST EFFECTS OF PRODUCT (FAMILY) CONCEPTS

Product concept generation and evaluation are critical for the success of new product developments (NPD) because managers need to select the most profitable product concepts. However, current approaches can be restricted to single products and do not cover product families' effects. Similarly, they do not necessarily capture all requirements and usually lack extensive cost analyses. Thus, this paper proposes a framework supporting product concept generation and evaluation by providing an accessible conceptualization to overcome the limitations. Using the so-called Extended Axiomatic Design (EAD) supports designers and managers to configure the requirements across product concepts' various domains while concurrently evaluating their economic consequences. The study applies the framework on a simplified case of a bottle manufacturer to conceptualize four product concepts. The case illustrates how the EAD can be used as a virtual testbed to generate and evaluate new product concepts. Finally, designers and managers can make more informed decisions about product concepts by considering their economic and engineering selection criteria to select the most profitable NPD project configuration.

DESIGN FOR FUTURE VARIETY TO ENABLE LONG-TERM BENEFITS OF MODULAR PRODUCT FAMILIES

By developing and using modular product families, large savings can be achieved through reuse and combinability along the entire value chain of a company. Since these potentials often have a very long-term character, the lifetime of a modular product family should be as long as possible. Change drivers, such as changing customer and production requirements, however, result in changes having to be made to the initially developed modular product family, which not only causes a great effort but also prevents the long-term benefits from being fully exploited. With the Change Allocation Model, we introduce a tool that makes it possible to align the essential future changes to the product architecture and to identify and redesign the change-critical components taking into account the existing component variety of the product family. This enables future changes in variety to be considered in the product architecture and a future robust modular product family to be developed. The new visualization is illustrated using the example of a product family of pressure regulating valves and is finally discussed with regard to further potentials and challenges.

TWO-LEVEL OPTIMIZATION OF PRODUCT FAMILIES: APPLICATION TO A PRODUCT FAMILY OF WATER HOSE BOXES

Increasing product complexity and individual customer requirements make the design of optimal product families difficult. Numerical optimization supports optimal design but must deal with the following challenges: many design variables, non-linear or discrete dependencies, and many possibilities of assigning shared components to products. Existing approaches use simplifications to alleviate those challenges. However, for use in industrial practice, they often use irrelevant commonality metrics, do not rely on the actual design variables of the product, or are unable to treat discrete variables. We present a two-level approach: (1) a genetic algorithm (GA) to find the best commonality scheme (i.e., assignment scheme of shared components to products) and (2) a particle swarm optimization (PSO) to optimize the design variables for one specific commonality scheme. It measures total cost, comprising manufacturing costs, economies of scales and complexity costs. The approach was applied to a product family consisting of five water hose boxes, each of them being subject to individual technical requirements. The results are discussed in the context of the product family design process.