scholarly journals Sigma Oscillations Protect or Reinstate Motor Memory Depending on their Temporal Coordination with Slow Waves

2021 ◽  
Author(s):  
Judith Nicolas ◽  
Brad R King ◽  
David Levesque ◽  
Latifa Lazzouni ◽  
Emily BJ Coffey ◽  
...  
Keyword(s):  
Beneficial Effect ◽  
Memory Consolidation ◽  
Crucial Role ◽  
Motor Performance ◽  
Irrelevant Information ◽  
Slow Waves ◽  
Motor Memory ◽  
Temporal Coordination ◽  
Phase Amplitude ◽  
Related Phase

Targeted memory reactivation (TMR) during post-learning sleep is known to enhance motor memory consolidation but the underlying neurophysiological processes remain unclear. Here, we confirm the beneficial effect of auditory TMR on motor performance. At the neural level, TMR enhanced slow waves (SW) characteristics. Additionally, greater TMR-related phase-amplitude coupling between slow (0.3-2 Hz) and sigma (12-16 Hz) oscillations after the SW peak was related to higher TMR effect on performance. Importantly, sounds that were not associated to learning strengthened SW-sigma coupling at the SW trough and the increase in sigma power nested in the trough of the potential evoked by these unassociated sounds was related to the TMR benefit. Altogether, our data suggest that, depending on their precise temporal coordination during post learning sleep, slow and sigma oscillations play a crucial role in either memory reinstatement or protection against irrelevant information; two processes that critically contribute to motor memory consolidation.

scholarly journals Medial Prefrontal-Hippocampal Connectivity and Motor Memory Consolidation in Depression and Schizophrenia

2015 ◽  
Vol 77 (2) ◽  
pp. 177-186 ◽  
Author(s):  
Lisa Genzel ◽  
Martin Dresler ◽  
Marion Cornu ◽  
Eugen Jäger ◽  
Boris Konrad ◽  
...  
Keyword(s):  
Memory Consolidation ◽  
Motor Memory

scholarly journals A method for event-related phase/amplitude coupling

NeuroImage ◽  
2013 ◽  
Vol 64 ◽  
pp. 416-424 ◽  
Author(s):  
Bradley Voytek ◽  
Mark D'Esposito ◽  
Nathan Crone ◽  
Robert T. Knight
Keyword(s):  
Phase Amplitude ◽  
Related Phase

Contribution of the Premotor Cortex to Consolidation of Motor Sequence Learning in Humans During Sleep

2010 ◽  
Vol 104 (5) ◽  
pp. 2603-2614 ◽  
Author(s):  
Michael A. Nitsche ◽  
Michaela Jakoubkova ◽  
Nivethida Thirugnanasambandam ◽  
Leonie Schmalfuss ◽  
Sandra Hullemann ◽  
...  
Keyword(s):  
Reaction Time ◽  
Task Performance ◽  
Rem Sleep ◽  
Sequence Learning ◽  
Memory Consolidation ◽  
Primary Motor Cortex ◽  
Premotor Cortex ◽  
Reaction Time Task ◽  
Motor Memory ◽  
Motor Sequence

Motor learning and memory consolidation require the contribution of different cortices. For motor sequence learning, the primary motor cortex is involved primarily in its acquisition. Premotor areas might be important for consolidation. In accordance, modulation of cortical excitability via transcranial DC stimulation (tDCS) during learning affects performance when applied to the primary motor cortex, but not premotor cortex. We aimed to explore whether premotor tDCS influences task performance during motor memory consolidation. The impact of excitability-enhancing, -diminishing, or placebo premotor tDCS during rapid eye movement (REM) sleep on recall in the serial reaction time task (SRTT) was explored in healthy humans. The motor task was learned in the evening. Recall was performed immediately after tDCS or the following morning. In two separate control experiments, excitability-enhancing premotor tDCS was performed 4 h after task learning during daytime or immediately before conduction of a simple reaction time task. Excitability-enhancing tDCS performed during REM sleep increased recall of the learned movement sequences, when tested immediately after stimulation. REM density was enhanced by excitability-increasing tDCS and reduced by inhibitory tDCS, but did not correlate with task performance. In the control experiments, tDCS did not improve performance. We conclude that the premotor cortex is involved in motor memory consolidation during REM sleep.

scholarly journals Does sleep selectively strengthen certain memories over others? A critical review of the literature

2020 ◽  
Author(s):  
Per Davidson ◽  
Peter Jönsson ◽  
Ingegerd Carlsson ◽  
Edward Pace-Schott
Keyword(s):  
Literature Review ◽  
Beneficial Effect ◽  
Eye Movement ◽  
Memory Consolidation ◽  
Critical Review ◽  
Special Focus ◽  
Rapid Eye Movement Sleep ◽  
Review Of The Literature ◽  
Test Expectancy ◽  
Emotional Memories

Sleep has been found to have a beneficial effect on memory consolidation. It has furthermore frequently been suggested that sleep does not strengthen all memories equally. The aim of this literature review was to examine the studies that have measured whether sleep selectively strengthens certain kinds of declarative memories more than others, depending on such factors as emotion, reward, test-expectancy or different instructions during encoding. The review of this literature revealed that although some support exists that sleep is more beneficial for certain kinds of memories, the majority of studies does not support such an effect. A second aim of this review was to examine which factors during sleep that have been found to selectively benefit certain memories over others, with a special focus on the often-suggested claim that rapid eye movement sleep primarily consolidates emotional memories. The review of this literature revealed that no sleep variable has been reliably found to be specifically associated with the consolidation of certain kinds of memories over others.

Phase-amplitude coupling of interictal fast activities modulated by slow waves on scalp EEG and its correlation with seizure outcomes of disconnection surgery in children with intractable nonlesional epileptic spasms

2021 ◽  
pp. 1-9
Author(s):  
Takehiro Uda ◽  
Ichiro Kuki ◽  
Takeshi Inoue ◽  
Noritsugu Kunihiro ◽  
Hiroharu Suzuki ◽  
...  
Keyword(s):  
Therapeutic Option ◽  
Surrogate Marker ◽  
Slow Waves ◽  
Seizure Freedom ◽  
Scalp Eeg ◽  
Epileptic Spasms ◽  
Posterior Quadrant ◽  
Before And After ◽  
Phase Amplitude

OBJECTIVEEpileptic spasms (ESs) are classified as focal, generalized, or unknown onset ESs. The classification of ESs and surgery in patients without lesions apparent on MRI is challenging. Total corpus callosotomy (TCC) is a surgical option for diagnosis of the lateralization and possible treatment for ESs. This study investigated phase-amplitude coupling (PAC) of fast activity modulated by slow waves on scalp electroencephalography (EEG) to evaluate the strength of the modulation index (MI) before and after disconnection surgery in children with intractable nonlesional ESs. The authors hypothesize that a decreased MI due to surgery correlates with good seizure outcomes.METHODSThe authors studied 10 children with ESs without lesions on MRI who underwent disconnection surgeries. Scalp EEG was obtained before and after surgery. The authors collected 20 epochs of 3 minutes each during non–rapid eye movement sleep. The MI of the gamma (30–70 Hz) amplitude and delta (0.5–4 Hz) phase was obtained in each electrode. MIs for each electrode were averaged in 4 brain areas (left/right, anterior/posterior quadrants) and evaluated to determine the correlation with seizure outcomes.RESULTSThe median age at first surgery was 2.3 years (range 10 months–9.1 years). Two patients with focal onset ESs underwent anterior quadrant disconnection (AQD). TCC alone was performed in 5 patients with generalized or unknown onset ESs. Two patients achieved seizure freedom. Three patients had residual generalized onset ESs. Disconnection surgeries in addition to TCC consisted of TCC + posterior quadrant disconnection (PQD) (1 patient); TCC + AQD + PQD (1 patient); and TCC + AQD + hemispherotomy (1 patient). Seven patients became seizure free with a mean follow-up period of 28 months (range 5–54 months). After TCC, MIs in 4 quadrants were significantly lower in the 2 seizure-free patients than in the 6 patients with residual ESs (p < 0.001). After all 15 disconnection surgeries in 10 patients, MIs in the 13 target quadrants for each disconnection surgery that resulted in freedom from seizures were significantly lower than in the 26 target quadrants in patients with residual ESs (p < 0.001).CONCLUSIONSIn children with nonlesional ESs, PAC for scalp EEG before and after disconnection surgery may be a surrogate marker for control of ESs. The MI may indicate epileptogenic neuronal modulation of the interhemispheric corpus callosum and intrahemispheric subcortical network for ESs. TCC may be a therapeutic option to disconnect the interhemispheric modulation of epileptic networks.

scholarly journals Bidirectional Interaction of Hippocampal Ripples and Cortical Slow Waves Leads to Coordinated Spiking Activity During NREM Sleep

2020 ◽  
Vol 31 (1) ◽  
pp. 324-340
Author(s):  
Pavel Sanda ◽  
Paola Malerba ◽  
Xi Jiang ◽  
Giri P Krishnan ◽  
Jorge Gonzalez-Martinez ◽  
...  
Keyword(s):  
Slow Wave ◽  
Memory Consolidation ◽  
Slow Wave Sleep ◽  
Nrem Sleep ◽  
Slow Waves ◽  
Slow Oscillation ◽  
Cortical Input ◽  
Sharp Wave ◽  
Up States ◽  
Intracranial Recordings

Abstract The dialogue between cortex and hippocampus is known to be crucial for sleep-dependent memory consolidation. During slow wave sleep, memory replay depends on slow oscillation (SO) and spindles in the (neo)cortex and sharp wave-ripples (SWRs) in the hippocampus. The mechanisms underlying interaction of these rhythms are poorly understood. We examined the interaction between cortical SO and hippocampal SWRs in a model of the hippocampo–cortico–thalamic network and compared the results with human intracranial recordings during sleep. We observed that ripple occurrence peaked following the onset of an Up-state of SO and that cortical input to hippocampus was crucial to maintain this relationship. A small fraction of ripples occurred during the Down-state and controlled initiation of the next Up-state. We observed that the effect of ripple depends on its precise timing, which supports the idea that ripples occurring at different phases of SO might serve different functions, particularly in the context of encoding the new and reactivation of the old memories during memory consolidation. The study revealed complex bidirectional interaction of SWRs and SO in which early hippocampal ripples influence transitions to Up-state, while cortical Up-states control occurrence of the later ripples, which in turn influence transition to Down-state.

scholarly journals 0104 The Effect of Time, Sleep, and Wake on Motor Memory Consolidation: A Partial Replication of Walker, Et Al. (2002)

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A41-A42
Author(s):  
M Tucker ◽  
I Wani
Keyword(s):  
Memory Consolidation ◽  
Memory Task ◽  
Skill Learning ◽  
Motor Memory ◽  
Partial Replication ◽  
Motor Sequence ◽  
Training Performance ◽  
Digit Sequence ◽  
Larger Sample ◽  
Typing Task

Abstract Introduction Findings from Walker, et al (2002) ‘Practice with Sleep Makes Perfect: Sleep-Dependent Motor Skill Learning’ demonstrate that performance on a widely used motor memory task (motor sequence task (MST)) benefits from a 12hr period of sleep (and not wake) even if the sleep period does not occur for approximately 12hrs after task acquisition, suggesting that sleep is crucial for motor memory consolidation. Using a larger sample, we attempted to replicate this finding, which is derived from Groups B & D from Walker et al (2002). Methods Participants (64 medical students: Age 21.2±0.8; N=33 females) were trained on the MST in the morning (10am; N=40) or evening (10pm; N=24) and then returned 12 and 24hrs later to be retested. The MST is a simple typing task that requires participants, at training, to type a 5-digit sequence (e.g., 4-1-3-2-4) as fast and accurately as possible over a series of 12 30-second trials with a 30-second break between each trial. At each retest, participants performed three 30-second trials. Results With 75% of the data collected we have found that when sleep follows training in the evening (first 12hr interval), the number of correctly typed sequences increased by 19.1% (cf. 20.5% in Walker (2002)). After a subsequent day of wake (second 12hr interval) performance increased by an additional 7.3% (cf. 2.0%). However, when a day of wake spanned the first 12hrs following training, performance increased by 14.5% (cf. 3.9%) followed by another 14.5% increase over the subsequent night (cf. 14.4%). Performance differences between sleep and wake participants were nonsignificant over the first 12hrs (p=0.38) and second 12hrs (p=0.49). Conclusion With most of data collection complete, our findings only partially replicate those of Walker et al (2002), and may draw into question the robustness of sleep for the processing motor memory. Support None

scholarly journals Role of the somatosensory cortex in motor memory consolidation

2020 ◽  
Vol 124 (3) ◽  
pp. 648-651
Author(s):  
Manasi Wali
Keyword(s):  
Motor Learning ◽  
Somatosensory Cortex ◽  
Memory Consolidation ◽  
Motor Memory ◽  
Implicit Motor Learning ◽  
Implicit Motor ◽  
Human Motor ◽  
Plos Biol

Motor memories become resistant to interference by the process of consolidation, which leads to long-term retention. Studies have shown involvement of the somatosensory cortex in motor learning-related plasticity, but not directly in motor memory consolidation. This Neuro Forum article reviews evidence from a continuous theta-burst transcranial magnetic stimulation (cTBS) study by Kumar and colleagues (Kumar N, Manning TF, Ostry DJ. PLoS Biol 17: e3000469, 2019) that demonstrates the role of somatosensory, rather than motor, cortex in human motor memory consolidation during implicit motor learning.

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