scholarly journals A comparison of single and multi-echo processing of fMRI data during overt autobiographical recall

2021 ◽  
Author(s):  
Adrian W. Gilmore ◽  
Anna M. Agron ◽  
Estefaniá I. González-Araya ◽  
Stephen J. Gotts ◽  
Alex Martin
Keyword(s):  
Standard Model ◽  
Data Processing ◽  
Spatial Resolution ◽  
Thermal Noise ◽  
Fmri Data ◽  
Autobiographical Memories ◽  
Hippocampal Activity ◽  
Autobiographical Recall ◽  
The Standard Model ◽  
Temporal And Spatial

Recent years have seen an increase in the use of multi-echo fMRI designs by cognitive neuroscientists. Acquiring multiple echoes allows one to reduce thermal noise and identify nuisance signal components in BOLD data (Kundu et al., 2012). At the same time, multi-echo acquisitions increase data processing complexity and may incur a cost to the temporal and spatial resolution of the acquired data. Here, we re-examine a multi-echo dataset (Gilmore et al., 2021) analyzed using multi-echo ICA (ME-ICA) and focused on hippocampal activity during the overly spoken recall of recent and remote autobiographical memories. The goal of the present series of analyses was to determine if ME-ICA's theoretical denoising benefits might lead to a practical difference in the overall conclusions reached. Compared to single echo data, ME-ICA led to qualitatively different conclusions regarding hippocampal contributions to autobiographical recall: whereas the single echo analysis largely failed to reveal hippocampal activity relative to an active baseline, ME-ICA results supported predictions of the Standard Model of Consolidation and a time limited hippocampal involvement (Alvarez and Squire, 1994). These data provide a practical example of the benefits multi-echo denoising in a naturalistic memory paradigm and demonstrate how they can be used to address long-standing theoretical questions.

scholarly journals Evidence supporting a time-limited hippocampal role in retrieving autobiographical memories

2021 ◽  
Vol 118 (12) ◽  
pp. e2023069118
Author(s):  
Adrian W. Gilmore ◽  
Alina Quach ◽  
Sarah E. Kalinowski ◽  
Estefanía I. González-Araya ◽  
Stephen J. Gotts ◽  
...  
Keyword(s):  
Standard Model ◽  
Time Series Data ◽  
Activity Patterns ◽  
Series Data ◽  
Hippocampal Activity ◽  
Autobiographical Recall ◽  
The Standard Model ◽  
Potential Benefits ◽  
Graded Activity ◽  
Fmri Time Series

The necessity of the human hippocampus for remote autobiographical recall remains fiercely debated. The standard model of consolidation predicts a time-limited role for the hippocampus, but the competing multiple trace/trace transformation theories posit indefinite involvement. Lesion evidence remains inconclusive, and the inferences one can draw from functional MRI (fMRI) have been limited by reliance on covert (silent) recall, which obscures dynamic, moment-to-moment content of retrieved memories. Here, we capitalized on advances in fMRI denoising to employ overtly spoken recall. Forty participants retrieved recent and remote memories, describing each for approximately 2 min. Details associated with each memory were identified and modeled in the fMRI time-series data using a variant of the Autobiographical Interview procedure, and activity associated with the recall of recent and remote memories was then compared. Posterior hippocampal regions exhibited temporally graded activity patterns (recent events > remote events), as did several regions of frontal and parietal cortex. Consistent with predictions of the standard model, recall-related hippocampal activity differed from a non-autobiographical control task only for recent, and not remote, events. Task-based connectivity between posterior hippocampal regions and others associated with mental scene construction also exhibited a temporal gradient, with greater connectivity accompanying the recall of recent events. These findings support predictions of the standard model of consolidation and demonstrate the potential benefits of overt recall in neuroimaging experiments.

scholarly journals The human hippocampus plays a time-limited role in retrieving autobiographical memories

2020 ◽  
Author(s):  
Adrian W. Gilmore ◽  
Alina Quach ◽  
Sarah E. Kalinowski ◽  
Estefanía I. Gonzalez-Araya ◽  
Stephen J. Gotts ◽  
...  
Keyword(s):  
Standard Model ◽  
Activity Patterns ◽  
Temporal Gradient ◽  
Human Hippocampus ◽  
Limited Role ◽  
Hippocampal Activity ◽  
Autobiographical Recall ◽  
The Standard Model ◽  
Potential Benefits ◽  
Graded Activity

ABSTRACTThe necessity of the human hippocampus for remote autobiographical recall remains fiercely debated. The standard model of consolidation predicts a time-limited role for the hippocampus, but the competing multiple trace/trace transformation theories posit indefinite involvement. Lesion evidence remains inconclusive, and the inferences one can draw from fMRI have been limited by reliance on covert (silent) recall, which obscures dynamic, moment-to-moment content of retrieved memories. Here, we capitalized on advances in fMRI denoising to employ overtly spoken recall. Forty participants retrieved recent and remote memories, describing each for approximately two minutes. Details associated with each memory were identified and modeled in the fMRI timeseries data using a variant of the Autobiographical Interview procedure, and activity associated with the recall of recent and remote memories was then compared. Posterior hippocampal regions exhibited temporally-graded activity patterns (recent events > remote events), as did several regions of frontal and parietal cortex. Consistent with predictions of the standard model, recall-related hippocampal activity differed from a non-autobiographical control task only for recent, and not remote, events. Task-based connectivity between posterior hippocampal regions and others associated with mental scene construction also exhibited a temporal gradient, with greater connectivity accompanying the recall of recent events. These findings support predictions of the standard model of consolidation and demonstrate the potential benefits of overt recall in neuroimaging experiments.

Indirect measurements in micro-space with the EM

1995 ◽  
Vol 53 ◽  
pp. 598-599
Author(s):  
Sterling P. Newberry
Keyword(s):  
Electron Microscope ◽  
Standard Model ◽  
Particle Physics ◽  
Information Storage ◽  
Storage Space ◽  
Indirect Measurements ◽  
Storage And Retrieval ◽  
Adequate Information ◽  
Compelling Reason ◽  
The Standard Model

At the 1958 meeting of our society, then known as EMSA, the author introduced the concept of microspace and suggested its use to provide adequate information storage space and the use of electron microscope techniques to provide storage and retrieval access. At this current meeting of MSA, he wishes to suggest an additional use of the power of the electron microscope.The author has been contemplating this new use for some time and would have suggested it in the EMSA fiftieth year commemorative volume, but for page limitations. There is compelling reason to put forth this suggestion today because problems have arisen in the “Standard Model” of particle physics and funds are being greatly reduced just as we need higher energy machines to resolve these problems. Therefore, any techniques which complement or augment what we can accomplish during this austerity period with the machines at hand is worth exploring.

An Interview with the Physicist that Her Head in the Universe and Both Feet on the Earth

2019 ◽  
Author(s):  
Adib Rifqi Setiawan
Keyword(s):  
Standard Model ◽  
Particle Physics ◽  
Space Time ◽  
Additional Dimension ◽  
The Earth ◽  
The Standard Model ◽  
The Universe

Put simply, Lisa Randall’s job is to figure out how the universe works, and what it’s made of. Her contributions to theoretical particle physics include two models of space-time that bear her name. The first Randall–Sundrum model addressed a problem with the Standard Model of the universe, and the second concerned the possibility of a warped additional dimension of space. In this work, we caught up with Randall to talk about why she chose a career in physics, where she finds inspiration, and what advice she’d offer budding physicists. This article has been edited for clarity. My favourite quote in this interview is, “Figure out what you enjoy, what your talents are, and what you’re most curious to learn about.” If you insterest in her work, you can contact her on Twitter @lirarandall.

An Interview with the Physicist that Her Head in the Universe and Both Feet on the Earth

2019 ◽  
Author(s):  
Adib Rifqi Setiawan
Keyword(s):  
Standard Model ◽  
Particle Physics ◽  
Space Time ◽  
Additional Dimension ◽  
The Earth ◽  
The Standard Model ◽  
The Universe

Put simply, Lisa Randall’s job is to figure out how the universe works, and what it’s made of. Her contributions to theoretical particle physics include two models of space-time that bear her name. The first Randall–Sundrum model addressed a problem with the Standard Model of the universe, and the second concerned the possibility of a warped additional dimension of space. In this work, we caught up with Randall to talk about why she chose a career in physics, where she finds inspiration, and what advice she’d offer budding physicists. This article has been edited for clarity. My favourite quote in this interview is, “Figure out what you enjoy, what your talents are, and what you’re most curious to learn about.” If you insterest in her work, you can contact her on Twitter @lirarandall.

Enhanced Attribute-Based Authenticated Key Agreement Protocol in the Standard Model

2014 ◽  
Vol 36 (10) ◽  
pp. 2156-2167
Author(s):  
Qiang LI ◽  
Deng-Guo FENG ◽  
Li-Wu ZHANG ◽  
Zhi-Gang GAO
Keyword(s):  
Standard Model ◽  
Key Agreement ◽  
Authenticated Key Agreement ◽  
Key Agreement Protocol ◽  
The Standard Model

Beyond the Standard Model

2017 ◽  
Author(s):  
Laurent Baulieu ◽  
John Iliopoulos ◽  
Roland Sénéor
Keyword(s):  
Field Theory ◽  
General Relativity ◽  
Supergravity Models ◽  
Standard Model ◽  
Field Theories ◽  
Beyond The Standard Model ◽  
Super Symmetry ◽  
The Standard Model ◽  
Topological Field ◽  
Supersymmetric Theories

The motivation for supersymmetry. The algebra, the superspace, and the representations. Field theory models and the non-renormalisation theorems. Spontaneous and explicit breaking of super-symmetry. The generalisation of the Montonen–Olive duality conjecture in supersymmetric theories. The remarkable properties of extended supersymmetric theories. A brief discussion of twisted supersymmetry in connection with topological field theories. Attempts to build a supersymmetric extention of the standard model and its experimental consequences. The property of gauge supersymmetry to include general relativity and the supergravity models.

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