Contraception in breast cancer survivors from the FEERIC case-control study (performed on behalf of the Seintinelles research network)

Objective: To compare the prevalence of contraception in breast cancer (BC) patients at risk of unintentional pregnancy (i.e. not currently pregnant or trying to get pregnant) and matched controls. Design: The FEERIC study (Fertility, Pregnancy, Contraception after BC in France) is a prospective, multicenter case-control study. Data were collected through online questionnaires completed on the Seintinelles* research platform. Setting: Not applicable Patient(s): BC patients aged from 18 to 43 years, matched for age and parity to cancer free volunteer controls in a 1:2 ratio. Intervention(s): None Results: In a population of 1278 women at risk of unintentional pregnancy, the prevalence of contraception at study inclusion did not differ significantly between cases (340/431, 78.9%) and controls (666/847, 78.6%, p=0.97). However, the contraceptive methods used were significantly different, with a higher proportion of copper IUD use in BC survivors (59.5% versus 25.0% in controls p<0.001). For patients at risk of unintentional pregnancy, receiving information about chemotherapy induced ovary damage at BC diagnosis (OR= 2.47 95%CI [ 1.39 - 4.37] and anti-HER2 treatment (OR=2.46, 95% CI [ 1.14 - 6.16]) were significantly associated with the use of a contraception in multivariate analysis. Discussion: In this large French study, BC survivors had a prevalence of contraception use similar to that for matched controls, though almost one in five women at risk of unintentional pregnancy did not use contraception. Dedicated consultations at cancer care centers could further improve access to information and contraception counseling.