Determination of Menarche Age of Students in Adolescence and Affecting Factors

The study was conducted as descriptive-sectional to investigate the age of menarche and the influencing factors of female students studying in the preparatory class of a state university. The universe of this research was the female students between February 2014-May 2015 in school of foreign languages at a state university. The study was held with all universe instead of sampling selection. 738 female students were voluntary participated into the study. Data were collected by the survey form. The menarche age of the participants is 13,3±1,12 (10-17) years old, and there is statistically significance between menarche age and body mass index (p<.001). The other statistically significance was available between menstrual period and weight change (p<.05). It has been found that the menarche age decreases as the students’ weight and BMI increases and the duration of the menstruation cycle increases. Factors affecting students’ menstruation order were investigated and it was determined that only weight change affects menstruation order. In the study, significant results were found between body mass index and age of menarche.

FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KEJADIAN NYERI MENSTRUASI (DISMINORE) PADA REMAJA PUTRI

Menstruation is endometrium releasing process included with bleeding and happened many times every month except in pregnancy. According to the World Health Organization (WHO) the number of disminore in the world is very large, the average more than 50 % of women in every country suffer from disminore. The aims of this research is to find out the correlation of menarche age, length of menstruation and family history with menstrual pain incident to the teenage girl of Social Class XI of Islamic Senior High School Number 1 year 2021. The method of this research used Survey Analitic with Cross Sectional approach. The populations in this research are all schoolgirls of Class XI of Islamic Senior High School Number 1 Palembang year 2021/2022, which amount 168 pepole. Big samples of this research are 63 respondents whom taken from using Stratified random sampling. Data collecting used questioner sheet. Data analysis used univariate and bivariate by using chi square test. Results : respondents who experience menstruation pain are 35 (55,6%) teenagers, normal menarche age respondents are 45 (71,4%) teenagers, respondents who experience normal menstruation length are 50 (79,4%) teenagers, respondents who have no disminore experiences family history are 42 (66,7%) teenagers. Bivariate result known that there is menarche age (length of menstruation) and family history (with menstruation pain incident to the teenage girls of Class XI of Islamic Senior High School Number 1 year 2021. The conclusion that there is correlation between menarche age, length of menstruation and family history with menstruation pain incident to the teenage girls of Social Class XI of Islamic Senior High School Number 1 year 2021. Suggestion : expected to the school authorities to cooperate with Health agencies to give counseling to the schoolgirls about female reproduction especially disminore.

The Factors Altering the Age of Onset of Menstruation among Adolescent Girls in Wardha Region

Introduction: Several studies have found that the most common age of menstruation onset has come down dramatically over the previous century, and that there has been a profane (with respect to time) tendency toward early menstruation onset in most metropolitan countries. Emerging economies, such as India, have also suffered a drop in recent years. The purpose of our study was to determine how diet and socioeconomic status influenced menarche age in this location. Methods: Following a simple random sampling among the schools, 100 girls between the ages of 10 and 15 were volunteered for this study. The girls were given a pre-designed questionnaire after receiving clearance and agreement from the school principal/class teacher. The female doctor gave the girls a brief examination. The age of the mother during menarche, as well as the family's socioeconomic situation and other characteristics, were all enquired about in depth. Results: Our study shows that the age of onset of menstruation in higher socioeconomic classes is lower as compared to Lower Socioeconomic class. No significant relation between BMI & type of food and usual age of onset of menstruation was seen in this study. Conclusions: As we progress from a lower to a better socioeconomic level, we see a trend of lowering the age of first menstrual flow. Because such data is scarce in this portion of India, more research must be conducted among girls from other parts of the state before the data can be compared to national figures.

Age at menarche, age at menopause, reproductive years and risk of fatal stroke occurrence among Chinese women: the Guangzhou Biobank Cohort Study

Background The relationship between women’s reproductive characteristics and stroke events is unclear. We aimed to investigate age at menarche, age at menopause and number of reproductive years in relation to fatal stroke occurrence in the Guangzhou Biobank Cohort Study. Methods In total, 16,504 postmenopausal women without stroke, heart disease or a cancer history at baseline were included and followed up for a median of 12.0 years. After review of available records, 222 stroke deaths were recorded. Cox proportional hazards regression was used to assess the associations between the risk of fatal stroke occurrence and age at menarche, age at menopause and number of reproductive years. Results In the whole cohort, compared with those aged 15 years at menarche, an increased risk of fatal stroke among women at menarche showed respectively in those aged 12 years (aHR (adjusted hazard ratio) = 1.86, 95% confidence interval (CI) 0.96–3.60), aged 13 years (aHR = 1.69, 95% CI 0.98–2.92), aged 17 years (aHR = 1.83, 95% CI 1.10–3.05) and aged ≥ 18 years (aHR = 1.66, 95% CI 1.03–2.70), wherein the associations revealed an atypically U-shaped; similar U-shaped association to the cohort of postmenopausal women born before 1940 released a range of incremental risks of fatal stroke in women at menarche aged ≤ 12 years (aHR = 3.68, 95% CI 1.68–8.05), aged 13 years (aHR = 2.11, 95% CI 1.02–4.34), aged 14 years (aHR = 2.07, 95% CI 1.04), aged 17 years (aHR = 2.30, 95% CI 1.20–4.39) and aged 18 years (aHR = 2.50, 95% CI 1.37–4.57), respectively. Compared with menopausal women aged 51–52 years, those aged < 43 years at menopause had an increased risk for fatal stroke among postmenopausal women born in and after 1940 (aHR = 1.64, 95% CI 0.97–2.78) and postmenopausal women born before 1940 (aHR = 1.97, 95% CI 1.05–3.69). Additionally, compared with those with 32–34 reproductive years, women with ≤ 28 reproductive years had an increased risk for fatal stroke in the whole cohort (aHR = 1.91, 95% CI 1.28–2.86) and the cohort of postmenopausal women born before 1940 (aHR = 1.79, 95% CI 1.15–2.80). Conclusions Younger and older age at menarche, younger age at menopause and fewer reproductive ages were related to an increased risk of fatal stroke in postmenopausal women.

Interactions between Polygenic Risk Scores, Dietary Pattern, and Menarche Age with the Obesity Risk in a Large Hospital-Based Cohort

Obese Asians are more susceptible to metabolic diseases than obese Caucasians of the same body mass index (BMI). We hypothesized that the genetic variants associated with obesity risk interact with the lifestyles of middle-aged and elderly adults, possibly allowing the development of personalized interventions based on genotype. We aimed to examine this hypothesis in a large city hospital-based cohort in Korea. The participants with cancers, thyroid diseases, chronic kidney disease, or brain-related diseases were excluded. The participants were divided into case and control according to their BMI: ≥25 kg/m2 (case; n = 17,545) and <25 kg/m2 (control; n = 36,283). The genetic variants that affected obesity risk were selected using a genome-wide association study, and the genetic variants that interacted with each other were identified by generalized multifactor dimensionality reduction analysis. The selected genetic variants were confirmed in the Ansan/Ansung cohort, and polygenetic risk scores (PRS)−nutrient interactions for obesity risk were determined. A high BMI was associated with a high-fat mass (odds ratio (OR) = 20.71) and a high skeletal muscle-mass index (OR = 3.38). A high BMI was positively related to metabolic syndrome and its components, including lipid profiles, whereas the initial menstruation age was inversely associated with a high BMI (OR = 0.78). The best model with 5-SNPs included SEC16B_rs543874, DNAJC27_rs713586, BDNF_rs6265, MC4R_rs6567160, and GIPR_rs1444988703. The high PRS with the 5-SNP model was positively associated with an obesity risk of 1.629 (1.475–1.798) after adjusting for the covariates. The 5-SNP model interacted with the initial menstruation age, fried foods, and plant-based diet for BMI risk. The participants with a high PRS also had a higher obesity risk when combined with early menarche, low plant-based diet, and a high fried-food intake than in participants with late menarche, high plant-based diet, and low fried-food intake. In conclusion, people with a high PRS and earlier menarche age are recommended to consume fewer fried foods and a more plant-based diet to decrease obesity risk. This result can be applied to personalized nutrition for preventing obesity.

Review Jurnal "Hubungan Status Gizi dengan Usia Menarche pada Remaja Putri"

The onset of menarche is part of physical and sexual maturity process. Previous studies have shown that the nutritional status of an adolescenst girl have important influence on the menarche age. The study was designed to determine the age of menarche and its relation to nutritional status of adolescent girls in SMP Negeri 10 Bulukumba. This was an analytical survey with a Cross Sectional Study approach. The sample in this study consisted of 74 people (total sampling), namely all students who had experienced menarche. The result of this study indicate that of the 74 respondents studied, there were 48 respondents had a good nutritional status, 43.75% had experienced normal menarche and 56.25% had experienced abnormal menarche. There were 26 respondents had a malnutrition, 15.38% had experienced normal menarche and 84.62% had experienced abnormal menarche. The results of statistical tests showed that there was an association between the nutritional status and the age at menarche of adolescent girls in SMP Negeri 10 Bulukumba (Pv=0,020; OR= 4,28). It is concluded that nutritional status is significantly associated with the age at menarche in adolesence. A good nutritional status in adolescent girls will experience puberty normally, resulting in normal and uninterrupted menstruation.

Review jurnal Hubungan Status Gizi dengan Usia Menarche pada Remaja Putri

The onset of menarche is part of physical and sexual maturity process. Previous studies have shown that the nutritional status of an adolescenst girl have important influence on the menarche age. The study was designed to determine the age of menarche and its relation to nutritional status of adolescent girls in SMP Negeri 10 Bulukumba. This was an analytical survey with a Cross Sectional Study approach. The sample in this study consisted of 74 people (total sampling), namely all students who had experienced menarche. The result of this study indicate that of the 74 respondents studied, there were 48 respondents had a good nutritional status, 43.75% had experienced normal menarche and 56.25% had experienced abnormal menarche. There were 26 respondents had a malnutrition, 15.38% had experienced normal menarche and 84.62% had experienced abnormal menarche. The results of statistical tests showed that there was an association between the nutritional status and the age at menarche of adolescent girls in SMP Negeri 10 Bulukumba (Pv=0,020; OR= 4,28). It is concluded that nutritional status is significantly associated with the age at menarche in adolesence. A good nutritional status in adolescent girls will experience puberty normally, resulting in normal and uninterrupted menstruation.Keywords: Menarche, adolescent, nutritional status.

Age at Menarche and Asthma Onset Among US Girls and Women: Findings from NHANES, 2001-2018

Background: Findings on the association between early menarche and asthma onset remain inconsistent and the evidence in the US is lacking. Furthermore, there was no clear separation of childhood- and adult-onset asthma in previous studies. Therefore, we aim at quantitatively estimating the association of age at menarche with risk of childhood- and adult-onset asthma separately in US girls and women.Methods: We conducted a retrospective cohort study of 24,282 US girls and women aged less than 80 years by using continuous NHANES data in 2001-2018. Weighted Cox proportional-hazards regression models with censoring ages of 19 and 79 were used to separately estimate hazard ratios of childhood- and adult-onset asthma associated with age at menarche. Results: Each one-year increase of age at menarche was significantly associated with a 17% (HR [95%CI]: 0.83 [0.77, 0.90]) decrease in the risk of childhood-onset asthma. Compared with age at menarche of 12-14, we observed a 60% (HR [95%CI]: 1.60 [1.22, 2.09]) increased risk of childhood-onset asthma for early menarche (age at menarche <12 years) and 41% (HR [95%CI]: 0.59 [0.32, 1.08]) decreased risk for late menarche (age at menarche ≥15 years). Race, family income, education and family history of asthma did not modify these associations. No significant association between age at menarche and adult-onset asthma.Conclusions: In this US nationally representative study, we found that early menarche was associated with increased risk of childhood-onset asthma, but not adult-onset asthma. These findings help demonstrate early menarche may be a risk factor for childhood-onset asthma in US, indicating timely and effective management of special individuals with early menarche for preventing asthma.

Association of miR-1251-5p/miR-6892-5p Expression With Clinicopathological Factors in Premenopausal Endometrial Cancer

Background This study is aim to profile the differentially expressed microRNAs (DEMs) of premenopausal endometrial cancer (EC), identify their target genes and understand their roles in carcinogenesis. Methods Next-generation sequencing (NGS) was performed on 3 premenopausal EC and 3 premenopausal normal endometrial tissues. Selection of candidate miRNAs and subsequent validation were performed by qRT-PCR on 20 premenopausal EC, 30 premenopausal normal endometrial and 40 postmenopausal EC samples. The relationship between DEMs and clinical characteristics was analyzed. Moreover, bioinformatic software programs and databases were applied to predict miRNA target genes, molecular functions, and signaling pathways. Results 136 upregulated and 131 downregulated DEMs were identified. The expression of miR-1251-5p was highly upregulated in premenopausal EC samples compared with premenopausal normal endometrial samples and significantly downregulated compared with postmenopausal EC samples. The expression of miR-6892-5p was highly upregulated in premenopausal EC samples compared with premenopausal normal endometrial samples and postmenopausal EC samples. In the premenopausal EC group, miR-1251-5p expression was closely correlated with menarche age, number of pregnancies, tumor grading, myometrial infiltration and lymph node metastasis; miR-6892-5p expression was closely correlated with BMI, hypertension, tumor grading, and metastasis. Conclusions miR-1251-5p and miR-6892-5p may play important roles in tumorigenesis progression of premenopausal EC.

Age At Menarche, Age At Menopause, Reproductive Years and Risk of Fatal Stroke Occurrence Among Chinese Women: The Guangzhou Biobank Cohort Study

Background The relationship between women’s reproductive characteristics and stroke events is unclear. We aimed to investigate age at menarche, age at menopause and number of reproductive years in relation to fatal stroke occurrence in the Guangzhou Biobank Cohort Study. Methods In total, 16504 postmenopausal women without stroke, heart disease or a cancer history at baseline were included and followed up for a median of 12.0 years. After review of available records, 222 stroke deaths were recorded. Cox proportional hazards regression was used to assess the associations between the risk of fatal stroke occurrence and age at menarche, age at menopause and number of reproductive years. Results In the whole cohort, compared with those aged 15 years at menarche, women aged 17 years at menarche had an increased risk for fatal stroke (adjusted hazard ratio [aHR] = 1.83, 95% confidence interval (CI) 1.10–3.05) and fatal haemorrhagic stroke (HR = 2.65, 95% CI 1.14–6.18), and women aged ≥ 18 years at menarche had an increased risk for fatal stroke (HR = 1.66, 95% CI 1.03–2.70) and fatal ischaemic stroke (HR = 2.01, 95% CI 1.01–3.99). Among postmenopausal women born before 1940, women aged < 43 years at menopause had an increased risk for fatal stroke (HR = 1.97, 95% CI 1.05–3.69) compared with those aged 51–52 years at menopause. Additionally, in the whole cohort, women with ≤ 28 reproductive years had an increased risk for fatal stroke (HR = 1.91, 95% CI 1.28–2.86) and fatal ischaemic stroke (HR = 2.26, 95% CI 1.26–4.05) compared with those with 32–34 reproductive years; postmenopausal women born before 1940 had a similar risk for fatal stroke and fatal ischaemic stroke. Conclusions Older age at menarche, younger age at menopause and fewer reproductive ages were related to an increased risk of fatal stroke in postmenopausal women.