scholarly journals Viral cultures, PCR Cycle threshold values and viral load estimation for COVID-19 infectious potential assessment in transplant patients: systematic review - Protocol Version 29 December 2021

2022 ◽  
Author(s):  
Tom Jefferson ◽  
Elizabeth A Spencer ◽  
Susanna Maltoni ◽  
Jon Brassey ◽  
IGHO ONAKPOYA ◽  
...  
Keyword(s):  
Systematic Review ◽  
Solid Organ ◽  
Hematopoietic Stem ◽  
Transplant Patients ◽  
Viral Culture ◽  
Viral Burden ◽  
Gene Copies ◽  
Cell Transplants ◽  
Review Protocol ◽  
Hematopoietic Stem Cell Transplants

This is the protocol for a systematic review focussing on people receiving solid organ or hematopoietic stem cell transplants. Our research questions are as follows: What is the relationship between serial PCR Ct value or other measures of viral burden, and the likelihood and duration of the presence of infectious virus from viral culture, among transplant recipients with SARS-CoV-2 infection? What is the influence of age, sex, underlying pathologies, degree of immunosuppression, vaccination status, COVID-19 symptoms and COVID-19 disease course on viral burden and the likelihood of presence of infectious SARS-CoV-2? We will include single studies reporting serial Cts from sequential rt-PCR testing or other measures of viral burden such as RNA gene copies of respiratory samples (from nasopharyngeal specimens) along with viral culture data on the same samples, from patients about to receive a transplant or who are post transplant with SARS-CoV-2 infection.

scholarly journals Infectious Complications in Autoimmune Hemolytic Anemia

2021 ◽  
Vol 10 (1) ◽  
pp. 164
Author(s):  
Juri Alessandro Giannotta ◽  
Bruno Fattizzo ◽  
Francesca Cavallaro ◽  
Wilma Barcellini
Keyword(s):  
Hemolytic Anemia ◽  
Autoimmune Hemolytic Anemia ◽  
Immunosuppressive Agents ◽  
Infectious Complications ◽  
Solid Organ ◽  
Systemic Autoimmune Diseases ◽  
Hematopoietic Stem ◽  
Infectious Risk ◽  
Cell Transplants ◽  
Hematopoietic Stem Cell Transplants

Autoimmune hemolytic anemia (AIHA) may be frequently challenged by infectious complications, mainly as a result of immunosuppressive treatments administered. Furthermore, infectious agents are known triggers of AIHA onset and relapse. Although being risk factors for mortality, infections are an underestimated issue in AIHA. This review will collect the available evidence on the frequency and type of infectious complications in AIHA, detailing the risk related to each treatment (i.e., steroids, rituximab, splenectomy, classic immunosuppressive agents, and new target drugs). Moreover, we will briefly discuss the infectious complications in AIHA secondary to other diseases that harbor an intrinsic infectious risk (e.g., primary immunodeficiencies, systemic autoimmune diseases, lymphoproliferative disorders, solid organ and hematopoietic stem cell transplants). Finally, viral and bacterial reactivations during immune suppressive therapies will be discussed, along with suggested screening and prophylactic strategies.

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