scholarly journals Cre-dependent optogenetic transgenic mice without early age-related hearing loss

2018 ◽  
Author(s):  
Daniel Lyngholm ◽  
Shuzo Sakata
Keyword(s):  
Hearing Loss ◽  
Transgenic Mice ◽  
Genetic Defect ◽  
F1 Hybrids ◽  
Early Age ◽  
F1 Hybrid ◽  
Hearing Research ◽  
Brain Functions ◽  
Age Related ◽  
Age Related Hearing Loss

AbstractWith the advent of recent genetic technologies for mice, it is now feasible to investigate the circuit mechanisms of brain functions in an unprecedented manner. Although transgenic mice are commonly used on C57BL/6J (C57) background, hearing research has typically relied on different genetic backgrounds, such as CBA/Ca or CBA due to the genetic defect of C57 mice for early age-related hearing loss. This limits the utilization of available genetic resources for hearing research. Here we report congenic (>F10) Cre-dependent channelrhodopsin2 (ChR2) mice on CBA/Ca background. By crossing this line with Cre-driver mice on C57 background, F1 hybrids restored the hearing deficit of C57 mice. We also found a linear relationship between aging and hearing loss, with progression rates varied depending on genetic backgrounds (3.39 dB/month for C57; 0.82 dB/month for F1 hybrid). We further demonstrate that this approach allows to express ChR2 in a specific type of inhibitory neurons in the auditory cortex and that they can be identified within a simultaneously recorded population of neurons in awake mice. Thus, our Cre-dependent optogenetic transgenic mice on CBA/Ca background are a valuable tool to investigate the circuit mechanisms of hearing across lifespan.

Genetics of age-related hearing loss in mice: I. Inbred and F1 hybrid strains

1993 ◽  
Vol 65 (1-2) ◽  
pp. 125-132 ◽  
Author(s):  
Lawrence C. Erway ◽  
James F. Willott ◽  
Jonathan R. Archer ◽  
David E. Harrison
Keyword(s):  
Hearing Loss ◽  
F1 Hybrid ◽  
Age Related ◽  
Age Related Hearing Loss

scholarly journals The Association Between Early Age‐Related Hearing Loss and Brain β‐Amyloid

2020 ◽  
Author(s):  
Justin S. Golub ◽  
Rahul K. Sharma ◽  
Brady Q. Rippon ◽  
Adam M. Brickman ◽  
José A. Luchsinger
Keyword(s):  
Hearing Loss ◽  
Early Age ◽  
Age Related ◽  
Β Amyloid ◽  
Age Related Hearing Loss

Deterioration of the Medial Olivocochlear Efferent System Accelerates Age-Related Hearing Loss in Pax2-Isl1 Transgenic Mice

2015 ◽  
Vol 53 (4) ◽  
pp. 2368-2383 ◽  
Author(s):  
Tetyana Chumak ◽  
Romana Bohuslavova ◽  
Iva Macova ◽  
Nicole Dodd ◽  
Daniela Buckiova ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Transgenic Mice ◽  
Efferent System ◽  
Age Related ◽  
Medial Olivocochlear ◽  
Medial Olivocochlear Efferent System ◽  
Age Related Hearing Loss

Genetics of age-related hearing loss in mice. III. Susceptibility of inbred and F1 hybrid strains to noise-induced hearing loss

1996 ◽  
Vol 93 (1-2) ◽  
pp. 181-187 ◽  
Author(s):  
Lawrence C. Erway ◽  
Yea-Wen Shiau ◽  
Rickie R. Davis ◽  
Edward F. Krieg
Keyword(s):  
Hearing Loss ◽  
Noise Induced Hearing Loss ◽  
F1 Hybrid ◽  
Age Related ◽  
Age Related Hearing Loss

scholarly journals Down-regulation of AMPK signaling pathway rescues hearing loss in TFB1 transgenic mice and delays age-related hearing loss

Aging ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 5590-5611
Author(s):  
Jingjing Zhao ◽  
Gen Li ◽  
Xuan Zhao ◽  
Xin Lin ◽  
Yunge Gao ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Transgenic Mice ◽  
Signaling Pathway ◽  
Down Regulation ◽  
Ampk Signaling ◽  
Age Related ◽  
Age Related Hearing Loss

Risk Factors of Age-related Hearing Loss, Adults over 65 Years in Korea: Including the Effect of the War Participation

2016 ◽  
Vol 17 (2) ◽  
pp. 68-73
Author(s):  
Dong-Wook Kim ◽  
Tae-Young Lee ◽  
Da-Hye Choi ◽  
Taek-Yeong Kim ◽  
Hyun-Chul Moon
Keyword(s):  
Risk Factors ◽  
Hearing Loss ◽  
Age Related ◽  
Age Related Hearing Loss

scholarly journals Chronic Oral Selegiline Treatment Mitigates Age-Related Hearing Loss in BALB/c Mice

2021 ◽  
Vol 22 (6) ◽  
pp. 2853
Author(s):  
Judit Szepesy ◽  
Viktória Humli ◽  
János Farkas ◽  
Ildikó Miklya ◽  
Júlia Tímár ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Hearing Aids ◽  
Dose Range ◽  
Auditory Brainstem ◽  
High Frequency Hearing Loss ◽  
Age Related ◽  
Hearing Function ◽  
Brainstem Response ◽  
Aging Societies ◽  
Age Related Hearing Loss

Age-related hearing loss (ARHL), a sensorineural hearing loss of multifactorial origin, increases its prevalence in aging societies. Besides hearing aids and cochlear implants, there is no FDA approved efficient pharmacotherapy to either cure or prevent ARHL. We hypothesized that selegiline, an antiparkinsonian drug, could be a promising candidate for the treatment due to its complex neuroprotective, antioxidant, antiapoptotic, and dopaminergic neurotransmission enhancing effects. We monitored by repeated Auditory Brainstem Response (ABR) measurements the effect of chronic per os selegiline administration on the hearing function in BALB/c and DBA/2J mice, which strains exhibit moderate and rapid progressive high frequency hearing loss, respectively. The treatments were started at 1 month of age and lasted until almost a year and 5 months of age, respectively. In BALB/c mice, 4 mg/kg selegiline significantly mitigated the progression of ARHL at higher frequencies. Used in a wide dose range (0.15–45 mg/kg), selegiline had no effect in DBA/2J mice. Our results suggest that selegiline can partially preserve the hearing in certain forms of ARHL by alleviating its development. It might also be otoprotective in other mammals or humans.

scholarly journals Reduced resting state functional connectivity with increasing age-related hearing loss and McGurk susceptibility

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Alina Schulte ◽  
Christiane M. Thiel ◽  
Anja Gieseler ◽  
Maike Tahden ◽  
Hans Colonius ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Functional Connectivity ◽  
Resting State ◽  
Mcgurk Effect ◽  
Functional Coupling ◽  
Resting State Functional Connectivity ◽  
Visual Integration ◽  
Age Related ◽  
Hearing Thresholds ◽  
Age Related Hearing Loss

Abstract Age-related hearing loss has been related to a compensatory increase in audio-visual integration and neural reorganization including alterations in functional resting state connectivity. How these two changes are linked in elderly listeners is unclear. The current study explored modulatory effects of hearing thresholds and audio-visual integration on resting state functional connectivity. We analysed a large set of resting state data of 65 elderly participants with a widely varying degree of untreated hearing loss. Audio-visual integration, as gauged with the McGurk effect, increased with progressing hearing thresholds. On the neural level, McGurk illusions were negatively related to functional coupling between motor and auditory regions. Similarly, connectivity of the dorsal attention network to sensorimotor and primary motor cortices was reduced with increasing hearing loss. The same effect was obtained for connectivity between the salience network and visual cortex. Our findings suggest that with progressing untreated age-related hearing loss, functional coupling at rest declines, affecting connectivity of brain networks and areas associated with attentional, visual, sensorimotor and motor processes. Especially connectivity reductions between auditory and motor areas were related to stronger audio-visual integration found with increasing hearing loss.

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