scholarly journals A recurrent novelMGA–NUTM1fusion identifies a new subtype of high-grade spindle cell sarcoma

2018 ◽  
Vol 4 (6) ◽  
pp. a003194 ◽  
Author(s):  
Daniel Diolaiti ◽  
Filemon S. Dela Cruz ◽  
Gunes Gundem ◽  
Nancy Bouvier ◽  
Mathieu Boulad ◽  
...  
Keyword(s):  
Spindle Cell ◽  
Spindle Cell Sarcoma ◽  
High Grade ◽  
Cell Sarcoma

High-grade spindle cell sarcoma arising in rhytidectomy scar: A case report

2010 ◽  
Vol 63 (5) ◽  
pp. e448-e450
Author(s):  
D. Jones ◽  
M.J. Earley
Keyword(s):  
Case Report ◽  
Spindle Cell ◽  
Spindle Cell Sarcoma ◽  
High Grade ◽  
Cell Sarcoma

INTRAARTERIAL CISPLATIN AND CAFFEINE WITH/WITHOUT DOXORUBICIN FOR MUSCULOSKELETAL HIGH-GRADE SPINDLE-CELL SARCOMA

1994 ◽  
Author(s):  
H TSUCHIYA ◽  
K TOMITA ◽  
H YASUTAKE ◽  
Y TAKAGI ◽  
S KATSUO ◽  
...  
Keyword(s):  
Spindle Cell ◽  
Spindle Cell Sarcoma ◽  
High Grade ◽  
Cell Sarcoma

scholarly journals Histochemical and ultrastructural study of an elastofibroma dorsi coexisting with a high grade spindle cell sarcoma

10.4081/884 ◽  
2009 ◽  
Vol 48 (2) ◽  
pp. 173 ◽  
Author(s):  
M Alberghini ◽  
P Bacchini ◽  
G Pignatti ◽  
MC Maltarello ◽  
L Zanella ◽  
...  
Keyword(s):  
Ultrastructural Study ◽  
Spindle Cell ◽  
Spindle Cell Sarcoma ◽  
High Grade ◽  
Cell Sarcoma ◽  
Elastofibroma Dorsi

scholarly journals Well-Differentiated Extraskeletal Osteosarcoma Arising from the Retroperitoneum That Recurred as Anaplastic Spindle Cell Sarcoma

2010 ◽  
Vol 2010 ◽  
pp. 1-5 ◽  
Author(s):  
Hiromasa Arai ◽  
Yasushi Rino ◽  
Teppei Nishii ◽  
Norio Yukawa ◽  
Nobuyuki Wada ◽  
...  
Keyword(s):  
Spindle Cell ◽  
Tumor Resection ◽  
Large Mass ◽  
Japanese Woman ◽  
Spindle Cell Sarcoma ◽  
Histopathological Diagnosis ◽  
High Grade ◽  
Extraskeletal Osteosarcoma ◽  
Cell Sarcoma ◽  
Well Differentiated

Extraskeletal osteosarcoma is an uncommon high-grade malignant soft tissue sarcoma. Well-differentiated extraskeletal osteosarcoma is thought to have a better prognosis than classical extraskeletal osteosarcoma, but dedifferentiation after recurrence has also been reported. We present a case of a primary retroperitoneal extraskeletal osteosarcoma in a 62-year-old Japanese woman. Abdominal CT revealed a large mass with diffuse calcification in the right retroperitoneal space and tumor resection was performed. The histopathological diagnosis was well-differentiated retroperitoneal extraskeletal osteosarcoma. She was followed up by CT every 6 months without adjuvant radiotherapy and chemotherapy for 31 months until anaplastic high-grade spindle cell sarcoma recurred in the retroperitoneum. Our case is the seventh reported description of well-differentiated extraskeletal sarcoma, and the first to arise in the retroperitoneum and recur as an entirely dedifferentiated spindle cell sarcoma.

scholarly journals Gemcitabine and docetaxel in relapsed and unresectable high-grade osteosarcoma and spindle cell sarcoma of bone

BMC Cancer ◽  
2016 ◽  
Vol 16 (1) ◽  
Author(s):  
E. Palmerini ◽  
R. L. Jones ◽  
E. Marchesi ◽  
A. Paioli ◽  
M. Cesari ◽  
...  
Keyword(s):  
Spindle Cell ◽  
Spindle Cell Sarcoma ◽  
High Grade ◽  
Cell Sarcoma ◽  
High Grade Osteosarcoma

scholarly journals Unique presentation of palatal metastasis from high-grade spindle cell sarcoma of the bone

2020 ◽  
Vol 13 (11) ◽  
pp. e236652
Author(s):  
Valentina Fenech ◽  
Anton Queen ◽  
Archana Gadve ◽  
Fiona Cowie
Keyword(s):  
Soft Palate ◽  
Spindle Cell ◽  
Bone Cancer ◽  
Surgical Excision ◽  
Malignant Tumour ◽  
Spindle Cell Sarcoma ◽  
High Grade ◽  
Cell Sarcoma ◽  
History Of ◽  
Primary Bone

Spindle cell sarcoma (SCS) is a rare malignant tumour which can arise in bone and accounts for 2%–5% of primary bone cancer cases. Distant metastasis occurs predominantly in the lungs. However, metastasis to the soft palate, to the best of our knowledge, has never been previously reported. In this case report, we describe a unique presentation of soft palate metastasis in a patient with a history of high-grade SCS of the bone who presented with progressive dysphagia and nausea and vomiting who underwent surgical excision for palliation of symptoms.

Malignant spindle cell tumors of the posterior fossa in children: case series and review of management

2021 ◽  
pp. 1-11
Author(s):  
Michael J. Gigliotti ◽  
Christine Mau ◽  
Charles S. Specht ◽  
Cynthia Lawson ◽  
Sarah McNutt ◽  
...  
Keyword(s):  
Literature Review ◽  
Posterior Fossa ◽  
Ewing Sarcoma ◽  
Spindle Cell ◽  
Spindle Cell Sarcoma ◽  
High Grade ◽  
Cell Sarcoma ◽  
Presenting Symptoms ◽  
Spindle Cell Tumors

OBJECTIVE The WHO Classification of Tumours of the Central Nervous System (2016) classifies nonmeningothelial malignant spindle cell tumors involving the extraaxial tissues of the posterior fossa as melanocytic tumors and malignant mesenchymal tumors (sarcomas). The objective of this study was to conduct a review of the literature pertaining to the management strategies of posterior fossa malignant spindle cell tumors in the pediatric population. METHODS The authors performed an institutional search of their pathology database for patients younger than 18 years of age who presented with posterior fossa malignant spindle cell tumors. A literature review was also performed using the PubMed database, with “posterior fossa” or “spindle cell tumors” or “Ewing sarcoma” or “high-grade” or “spindle cell sarcoma” or “leptomeningeal melanocytoma” as keywords. The database search was restricted to pediatric patients (age ≤ 18 years). Parameters reported from the literature review included patient age, tumor location, presenting symptoms, treatment modalities (resection, chemotherapy, and/or radiotherapy), leptomeningeal spread at or after the time of treatment, and follow-up length and resulting outcome. RESULTS The authors report 3 rare cases of posterior fossa malignant spindle cell tumors, including Ewing sarcoma in a 13-year-old male; high-grade spindle cell sarcoma, not otherwise specified in a 10-year-old male; and primary leptomeningeal melanocytoma in a 16-year-old female. All 3 patients underwent resection and radiotherapy and either chemotherapy or targeted immunotherapy. At the last follow-up, all patients were alive with either resolution or stable disease. CONCLUSIONS A review of these 3 cases and the existing literature support managing patients with intracranial malignant spindle cell tumors with multimodal therapy that can include a combination of resection, radiotherapy, and chemotherapy or immunotherapy to prolong progression-free and overall survival.

Extra-Articular Hip Resection and Reconstruction with Custom Acetabular Resection Guide and Implants in a Case of High-Grade Spindle Cell Sarcoma of the Proximal Femur

2020 ◽  
Vol 10 (3) ◽  
pp. e19.00529-e19.00529
Author(s):  
Jorge Manrique ◽  
Corey J. Schiffman ◽  
Albert D. Chan ◽  
David Olsen ◽  
Matthew J. Thompson
Keyword(s):  
Proximal Femur ◽  
Spindle Cell ◽  
Spindle Cell Sarcoma ◽  
High Grade ◽  
Cell Sarcoma
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