scholarly journals Unique presentation of palatal metastasis from high-grade spindle cell sarcoma of the bone

2020 ◽  
Vol 13 (11) ◽  
pp. e236652
Author(s):  
Valentina Fenech ◽  
Anton Queen ◽  
Archana Gadve ◽  
Fiona Cowie
Keyword(s):  
Soft Palate ◽  
Spindle Cell ◽  
Bone Cancer ◽  
Surgical Excision ◽  
Malignant Tumour ◽  
Spindle Cell Sarcoma ◽  
High Grade ◽  
Cell Sarcoma ◽  
History Of ◽  
Primary Bone

Spindle cell sarcoma (SCS) is a rare malignant tumour which can arise in bone and accounts for 2%–5% of primary bone cancer cases. Distant metastasis occurs predominantly in the lungs. However, metastasis to the soft palate, to the best of our knowledge, has never been previously reported. In this case report, we describe a unique presentation of soft palate metastasis in a patient with a history of high-grade SCS of the bone who presented with progressive dysphagia and nausea and vomiting who underwent surgical excision for palliation of symptoms.

INTRAARTERIAL CISPLATIN AND CAFFEINE WITH/WITHOUT DOXORUBICIN FOR MUSCULOSKELETAL HIGH-GRADE SPINDLE-CELL SARCOMA

1994 ◽  
Author(s):  
H TSUCHIYA ◽  
K TOMITA ◽  
H YASUTAKE ◽  
Y TAKAGI ◽  
S KATSUO ◽  
...  
Keyword(s):  
Spindle Cell ◽  
Spindle Cell Sarcoma ◽  
High Grade ◽  
Cell Sarcoma

scholarly journals Histochemical and ultrastructural study of an elastofibroma dorsi coexisting with a high grade spindle cell sarcoma

10.4081/884 ◽  
2009 ◽  
Vol 48 (2) ◽  
pp. 173 ◽  
Author(s):  
M Alberghini ◽  
P Bacchini ◽  
G Pignatti ◽  
MC Maltarello ◽  
L Zanella ◽  
...  
Keyword(s):  
Ultrastructural Study ◽  
Spindle Cell ◽  
Spindle Cell Sarcoma ◽  
High Grade ◽  
Cell Sarcoma ◽  
Elastofibroma Dorsi

scholarly journals Well-Differentiated Extraskeletal Osteosarcoma Arising from the Retroperitoneum That Recurred as Anaplastic Spindle Cell Sarcoma

2010 ◽  
Vol 2010 ◽  
pp. 1-5 ◽  
Author(s):  
Hiromasa Arai ◽  
Yasushi Rino ◽  
Teppei Nishii ◽  
Norio Yukawa ◽  
Nobuyuki Wada ◽  
...  
Keyword(s):  
Spindle Cell ◽  
Tumor Resection ◽  
Large Mass ◽  
Japanese Woman ◽  
Spindle Cell Sarcoma ◽  
Histopathological Diagnosis ◽  
High Grade ◽  
Extraskeletal Osteosarcoma ◽  
Cell Sarcoma ◽  
Well Differentiated

Extraskeletal osteosarcoma is an uncommon high-grade malignant soft tissue sarcoma. Well-differentiated extraskeletal osteosarcoma is thought to have a better prognosis than classical extraskeletal osteosarcoma, but dedifferentiation after recurrence has also been reported. We present a case of a primary retroperitoneal extraskeletal osteosarcoma in a 62-year-old Japanese woman. Abdominal CT revealed a large mass with diffuse calcification in the right retroperitoneal space and tumor resection was performed. The histopathological diagnosis was well-differentiated retroperitoneal extraskeletal osteosarcoma. She was followed up by CT every 6 months without adjuvant radiotherapy and chemotherapy for 31 months until anaplastic high-grade spindle cell sarcoma recurred in the retroperitoneum. Our case is the seventh reported description of well-differentiated extraskeletal sarcoma, and the first to arise in the retroperitoneum and recur as an entirely dedifferentiated spindle cell sarcoma.

Leiomyosarcoma of the Foot

2007 ◽  
Vol 97 (6) ◽  
pp. 475-479 ◽  
Author(s):  
Erin Engel ◽  
Michael Butler ◽  
Joseph Anain
Keyword(s):  
United States ◽  
Differential Diagnosis ◽  
Malignant Tumor ◽  
Clinical Presentation ◽  
Spindle Cell ◽  
Pyogenic Granuloma ◽  
The United States ◽  
Spindle Cell Sarcoma ◽  
Cell Sarcoma ◽  
History Of

Leiomyosarcoma is a very rare malignant tumor, with only 28 new cases diagnosed in the United States each year. The prognosis varies, with average 5-year survival of 65%. Although most leiomyosarcomas occur in the lower extremity, there is a paucity in the literature on these sarcomas in the foot. Only 15 cases of leiomyosarcoma in the foot have been reported in the literature since the mid-1930s. We describe a 31-year-old man with a history of an ingrown toenail and nonhealing pyogenic granuloma. His clinical presentation suggested atypical tissue. Biopsy findings confirmed the diagnosis of spindle cell sarcoma, specifically, leiomyosarcoma. The patient was treated with amputation of the affected hallux and adjuvant therapy. The similar presentations of a pyogenic granuloma and a malignant tumor necessitate a thorough differential diagnosis with even common foot ailments. (J Am Podiatr Med Assoc 97(6): 475–479, 2007)

scholarly journals Gemcitabine and docetaxel in relapsed and unresectable high-grade osteosarcoma and spindle cell sarcoma of bone

BMC Cancer ◽  
2016 ◽  
Vol 16 (1) ◽  
Author(s):  
E. Palmerini ◽  
R. L. Jones ◽  
E. Marchesi ◽  
A. Paioli ◽  
M. Cesari ◽  
...  
Keyword(s):  
Spindle Cell ◽  
Spindle Cell Sarcoma ◽  
High Grade ◽  
Cell Sarcoma ◽  
High Grade Osteosarcoma

scholarly journals Late-Onset Metastatic Malignant Spindle Cell Tumour Presenting with Massive Intra-Abdominal Haemorrhage

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Pamathy Gnanaselvam ◽  
Malintha Lahiru ◽  
Mariathas Priatharshan ◽  
Umesh Jayarajah ◽  
Kathirvetpillai Kopinath
Keyword(s):  
Spindle Cell ◽  
Late Onset ◽  
Cell Tumour ◽  
Histological Evaluation ◽  
Spindle Cell Sarcoma ◽  
Rare Tumour ◽  
Cell Sarcoma ◽  
Metastatic Deposit ◽  
History Of ◽  
Spindle Cell Tumour

Primary spindle cell sarcoma is a rare tumour. The presentation of acute intra-abdominal bleeding from a metastatic spindle cell tumour has not been previously reported. We report a case of a 40-year-old woman with a history of curative resection of the medial compartment of the right thigh for spindle cell sarcoma presenting with an acute onset abdominal pain and haemorrhagic shock after 5 uneventful years. Emergency exploratory laparotomy was conducted that revealed a retropancreatic mass which had ruptured along its inferior border. Histological evaluation revealed a metastatic deposit of the spindle cell sarcoma. In cases of spontaneous abdominal haemorrhage, it is important to consider the possibility of a ruptured metastatic deposit among the differentials especially in patients with a history of malignancies. Moreover, this is the first reported case of metastatic malignant spindle cell sarcoma presenting with intra-abdominal haemorrhage.

Malignant spindle cell tumors of the posterior fossa in children: case series and review of management

2021 ◽  
pp. 1-11
Author(s):  
Michael J. Gigliotti ◽  
Christine Mau ◽  
Charles S. Specht ◽  
Cynthia Lawson ◽  
Sarah McNutt ◽  
...  
Keyword(s):  
Literature Review ◽  
Posterior Fossa ◽  
Ewing Sarcoma ◽  
Spindle Cell ◽  
Spindle Cell Sarcoma ◽  
High Grade ◽  
Cell Sarcoma ◽  
Presenting Symptoms ◽  
Spindle Cell Tumors

OBJECTIVE The WHO Classification of Tumours of the Central Nervous System (2016) classifies nonmeningothelial malignant spindle cell tumors involving the extraaxial tissues of the posterior fossa as melanocytic tumors and malignant mesenchymal tumors (sarcomas). The objective of this study was to conduct a review of the literature pertaining to the management strategies of posterior fossa malignant spindle cell tumors in the pediatric population. METHODS The authors performed an institutional search of their pathology database for patients younger than 18 years of age who presented with posterior fossa malignant spindle cell tumors. A literature review was also performed using the PubMed database, with “posterior fossa” or “spindle cell tumors” or “Ewing sarcoma” or “high-grade” or “spindle cell sarcoma” or “leptomeningeal melanocytoma” as keywords. The database search was restricted to pediatric patients (age ≤ 18 years). Parameters reported from the literature review included patient age, tumor location, presenting symptoms, treatment modalities (resection, chemotherapy, and/or radiotherapy), leptomeningeal spread at or after the time of treatment, and follow-up length and resulting outcome. RESULTS The authors report 3 rare cases of posterior fossa malignant spindle cell tumors, including Ewing sarcoma in a 13-year-old male; high-grade spindle cell sarcoma, not otherwise specified in a 10-year-old male; and primary leptomeningeal melanocytoma in a 16-year-old female. All 3 patients underwent resection and radiotherapy and either chemotherapy or targeted immunotherapy. At the last follow-up, all patients were alive with either resolution or stable disease. CONCLUSIONS A review of these 3 cases and the existing literature support managing patients with intracranial malignant spindle cell tumors with multimodal therapy that can include a combination of resection, radiotherapy, and chemotherapy or immunotherapy to prolong progression-free and overall survival.

Sign in / Sign up

Export Citation Format

Share Document