We consider the canonical quantization of a generalized two-dimensional massive fermion theory containing higher odd-order derivatives. The requirements of Lorentz invariance, hermiticity of the Hamiltonian and absence of tachyon excitations suffice to fix the mass term, which contains a derivative coupling. We show that the basic quantum excitations of a higher-derivative theory of order 2N+1 consist of a physical usual massive fermion, quantized with positive metric, plus 2N unphysical massless fermions, quantized with opposite metrics. The positive-metric Hilbert subspace, which is isomorphic to the space of states of a massive free fermion theory, is selected by a subsidiary-like condition. Employing the standard bosonization scheme, the equivalent boson theory is derived. The results obtained are used as a guideline to discuss the solution of a theory including a current–current interaction.