Intrinsically disordered proteins (IDPs) widely involve in human diseases and are thus attractive therapeutic targets. In practice, however, it is computationally prohibitive to dock large ligand libraries to thousands and...
Intrinsically disordered proteins (IDPs) have not fixed tertiary structure under physiology condition and associate with many human diseases. Because IDPs have the characters of diverse conformation, current experimental methods can...
Intrinsically disordered proteins (IDPs) have gained much attention in recent years due to their vital roles in biology and prevalence in various human diseases. Although IDPs are perceived as attractive...
Mutations in short linear motifs impair the functions of intrinsically disordered proteins in cellular signaling/regulation and contribute substantially to human diseases.