Extracellular recording system based on amplitude modulation for CMOS microelectrode arrays

Author(s):  
Neil Joye ◽  
Alexandre Schmid ◽  
Yusuf Leblebici
2017 ◽  
Vol 2 (3) ◽  
pp. 035003 ◽  
Author(s):  
Bernd Bachmann ◽  
Nouran Y Adly ◽  
Jan Schnitker ◽  
Alexey Yakushenko ◽  
Philipp Rinklin ◽  
...  

2019 ◽  
Vol 11 (46) ◽  
pp. 5872-5879 ◽  
Author(s):  
Xinwei Wei ◽  
Qing Gao ◽  
Chaoqi Xie ◽  
Chenlei Gu ◽  
Tao Liang ◽  
...  

To mimic the heart in vitro, here, we reported a new method about the extracellular recording of engineered cardiac tissue based on a porous scaffold and microelectrode arrays, and it is expected to be applied to pharmaceutical studies.


2011 ◽  
Vol 27 (1) ◽  
pp. 12-17 ◽  
Author(s):  
Qingjun Liu ◽  
Ning Hu ◽  
Weiwei Ye ◽  
Hua Cai ◽  
Fenni Zhang ◽  
...  

2011 ◽  
Vol 8 (1) ◽  
pp. 38-44
Author(s):  
Neil Joye ◽  
Alexandre Schmid ◽  
Yusuf Leblebici

2019 ◽  
Author(s):  
Cole L. Hurwitz ◽  
Kai Xu ◽  
Akash Srivastava ◽  
Alessio P. Buccino ◽  
Matthias H. Hennig

AbstractDetermining the positions of neurons in an extracellular recording is useful for investigating functional properties of the underlying neural circuitry. In this work, we present a Bayesian modelling approach for localizing the source of individual spikes on high-density, microelectrode arrays. To allow for scalable inference, we implement our model as a variational autoencoder and perform amortized variational inference. We evaluate our method on both biophysically realistic simulated and real extracellular datasets, demonstrating that it is more accurate than and can improve spike sorting performance over heuristic localization methods such as center of mass.


2020 ◽  
Author(s):  
R Bestel ◽  
U van Rienen ◽  
C Thielemann ◽  
R Appali

AbstractObjectiveMeasuring neuronal cell activity using microelectrode arrays reveals a great variety of derived signal shapes within extracellular recordings. However, possible mechanisms responsible for this variety have not yet been entirely determined, which might hamper any subsequent analysis of the recorded neuronal data. For an investigation of this issue, we propose a computational model based on the finite element method describing the electrical coupling between an electrically active neuron and an extracellular recording electrode in detail. This allows for a systematic study of possible parameters that may play an essential role in defining or altering the shape of the measured electrode potential. Our results indicate that neuronal geometry and neurite structure, as well as the actual pathways of input potentials that evoke action potential generation, have a significant impact on the shape of the resulting extracellular electrode recording and explain most of the known signal shape variety.


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