Magnetically induced deep brain stimulation of neuronal firing for pain relief

Author(s):  
Fan Jie ◽  
Wu Tiecheng ◽  
Lee Kim Seng ◽  
Lee Xiaoping Li
2020 ◽  
Vol 124 (5) ◽  
pp. 1518-1529
Author(s):  
Edward M. Bello ◽  
Filippo Agnesi ◽  
Yizi Xiao ◽  
Joan Dao ◽  
Matthew D. Johnson

The network mechanisms of thalamic deep brain stimulation (DBS) are not well understood at the cellular level. This study investigated the neuronal firing rate and pattern changes in the motor cortex resulting from stimulation of the cerebellar-receiving area of the motor thalamus. We showed that there is a nonintuitive relationship between general entropy-based spike-pattern measures and phase-locked regularization to DBS.


2015 ◽  
Vol 263 (2) ◽  
pp. 290-298 ◽  
Author(s):  
Cécile Delorme ◽  
Alister Rogers ◽  
Brian Lau ◽  
Hélène Francisque ◽  
Marie-Laure Welter ◽  
...  

2020 ◽  
Vol 132 (3) ◽  
pp. 717-720 ◽  
Author(s):  
Sérgio A. F. Dantas ◽  
Eduardo J. L. Alho ◽  
Juliano J. da Silva ◽  
Nilson N. Mendes Neto ◽  
Erich Talamoni Fonoff ◽  
...  

Hypothalamic deep brain stimulation (DBS) has been used for more than a decade to treat cluster headache (CH) but its mechanisms remain poorly understood. The authors have successfully treated a patient with CH using hypothalamic DBS and found that the contact used for chronic stimulation was located in a white matter region posterior to the mammillary bodies. Fiber tracts crossing that region were the medial forebrain bundle and those interconnecting the hypothalamus and brainstem, including the dorsal longitudinal fasciculus. Because the stimulation of axons is an important mechanism of DBS, some of its clinical effects in CH may be related to the stimulation of fibers interconnecting the hypothalamus and brainstem.


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