Feasibility of focal brain cooling for partial epilepsy with secondary generalization: A computational study*

2020 ◽  
Author(s):  
Jaymar Soriano ◽  
Takatomi Kubo ◽  
Kazushi Ikeda
Keyword(s):  
Computational Study ◽  
Partial Epilepsy ◽  
Brain Cooling ◽  
Secondary Generalization

scholarly journals Is elevated pre-ictal heart rate associated with secondary generalization in partial epilepsy?

Seizure ◽  
2010 ◽  
Vol 19 (5) ◽  
pp. 291-295 ◽  
Author(s):  
Kristian Bernhard Nilsen ◽  
Marit Haram ◽  
Solveig Tangedal ◽  
Trond Sand ◽  
Eylert Brodtkorb
Keyword(s):  
Heart Rate ◽  
Partial Epilepsy ◽  
Secondary Generalization

Long-term electrical stimulation–induced inhibition of partial epilepsy

2006 ◽  
Vol 105 (6) ◽  
pp. 894-897 ◽  
Author(s):  
Kost Elisevich ◽  
Ken Jenrow ◽  
Lori Schuh ◽  
Brien Smith
Keyword(s):  
Electrical Stimulation ◽  
Seizure Frequency ◽  
Primary Motor Cortex ◽  
Cortical Excitability ◽  
Focal Epilepsy ◽  
Partial Epilepsy ◽  
Over Time ◽  
Secondary Generalization ◽  
Stimulation Of

✓The aim of this study was to determine the effects of long-term continuous cerebrocortical electrical stimulation in the treatment of partial epilepsy. The authors review the case of a 44-year-old man with medically intractable postencephalitic localization-related epilepsy with ictal onset in the primary motor cortex. For 5 years he was treated using patterned subthreshold electrical stimulation of the ictal site. This therapy has successfully eliminated the jacksonian march of cortical excitability and secondary generalization and reduced seizure frequency and intensity with an immediate postictal return of motor function. Over time, the seizure frequency subsided by more than 90%, with the patient showing no adverse features resulting from focal stimulation. The results in this case support the hypothesis that effective and safe long-term modulation of focal epilepsy is possible with focal cerebrocortical electrical stimulation.

Factors associated with relapse after antiepileptic drug withdrawal in a selected population with partial epilepsy

1999 ◽  
Vol 41 (9) ◽  
pp. 643-645 ◽  
Author(s):  
Alberto Verrotti ◽  
Simonetta Morresi ◽  
Rocco Cutarella ◽  
Guido Morgese ◽  
Francesco Chiarelli
Keyword(s):  
Antiepileptic Drug ◽  
Drug Withdrawal ◽  
Partial Epilepsy ◽  
Factors Associated ◽  
Antiepileptic Drug Withdrawal

Vergleich von Blutfluß und Benzodiazepin-Rezeptorverteilung bei fokaler Epilepsie: Vorläufige Ergebnisse einer SPECT-Studie

1989 ◽  
Vol 28 (05) ◽  
pp. 181-186
Author(s):  
A. Ludolph ◽  
O. Schober ◽  
G. Lottes ◽  
I. Böttger ◽  
H.-F. Beer ◽  
...  
Keyword(s):  
Human Brain ◽  
Receptor Binding ◽  
Brain Area ◽  
Brain Perfusion ◽  
Partial Epilepsy ◽  
Cerebral Lesion ◽  
Receptor Ligand ◽  
Receptor Mapping ◽  
Hmpao Spect ◽  
99Mtc Hmpao

99mTc-HMPAO-SPECT and SPECT with the 123I-labelled benzodiazepine (Bz) receptor ligand Ro 16-0154 were performed in 10 patients suffering from partial epilepsy, without cerebral lesion in MRT or CT. 2 h p.i. of Ro 16-0154 the distribution of activity correlated with the known distribution of Bz- receptors in the human brain. Perfusion and receptor-binding were found decreased in 7 patients of each study in the suspicious brain-area. 123l-labelled Ro 16-0154 is suitable for Bz-receptor mapping by SPECT. The decrease of Bz-receptor binding in epileptic foci, as described in PET-studies, was also detected by SPECT in 7 of 10 patients.

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