E-health evaluation, which involves different dimensions, has increased. In traditional healthcare, quality dimensions exist but these are not sufficiently exploited for e-health. Reliability is often examined regarding technology, software, demand and survival. This chapter reviews the reasons that e-health systems need to be evaluated, the methods followed for conducting e-health evaluation studies and the main points that characterize an evaluation procedure as successful. Many researchers have presented evaluation considerations for e-health. Herein, the emphasis is on analyzing a series of ideas mined from the scientific literature that allows drawing up practical considerations for e-health evaluation. These considerations focus both on quality and reliability assurance as well as on quality and reliability improvement.