In many countries, the use of the KTX high-speed rail has been generalized of late. Therefore, its customers who initially pursued only convenience and speed have begun pursuing quality services such as comfort and stability. Thus, the importance of reducing the noise in the high-speed rail is increasing. The active noise is best choice to reduce noise because of being able to actively reduce the ambient noise coming from the environmental-factor changes. But it’s too hard in a three-dimensional closed-space sound field such as the interior of a high-speed rail. In this study, we used multichannel(2x2) FXLMS algorithm for applying ANC system in KTX. In detail, after measuring the noise inside KTX during its runs in South Korea, multichannel active noise control was simulated to determine the extent to which it can reduce the noise inside KTX. Simulation was done using a multichannel FXLMS algorithm for reducing the actual noise inside KTX and the noise reduction in the open-space section of KTX was compared with that in the tunnel section, and the active-noise-control performances in the low-frequency (below 500 Hz) region were compared.