Study on Public Chest X-ray Data sets for Lung Disease Classification

Background:Interstitial lung disease (ILD) in inflammatory rheumatic diseases (IRD) is associated with increased mortality. Moreover, the lung is one of the most effected organs on IRD. Consequently, screening methods were required to the detect ILD in IRD.Objectives:The objective of the following study is to evaluate the diagnostic value of lung function test, chest x-ray and HR-CT of the lung in the detection of ILD at the onset of IRD.Methods:The study is designed as a case-control study and includes 126 patients with a newly diagnosed IRD. It was matched by gender, age and the performance of lung function test and chest x-ray. The sensitivity and specificity were verified by crosstabs and receiver operating characteristic (ROC) curve analysis. The study cohort was divided in two groups (ILD group: n = 63 and control group: n = 63). If possible, all patients received a lung function test and optional a chest x-ray. Patients with pathological findings in the screening tests (chest x-ray or reduced diffusing capacity for carbon monoxide (DLCO) < 80 %) maintained a high-resolution computer tomography (HR-CT) of the lung. Additionally, an immunological bronchioalveolar lavage was performed in the ILD group as gold standard for the detection of ILD.Results:The DLCO (< 80 %) revealed a sensitivity of 83.6 % and specificity of 45.8 % for the detection of ILD. Other examined parameter of lung function test showed no sufficient sensitivity as screening test (FVC = Forced Vital Capacity, FEV1 = Forced Expiratory Volume in 1 second, TLC = Total Lung Capacity, TLCO = Transfer factor of the Lung for carbon monoxide). Also, a combination of different parameter did not increase the sensitivity. The sensitivity and specificity of chest x-ray for the verification of ILD was 64.2 % versus 73.6 %. The combination of DLCO (< 80 %) and chest x-ray showed a sensitivity with 95.2 % and specificity with 38.7 %. The highest sensitivity (95.2 %) and specificity (77.4 %) was observed for the combination of DLCO (< 80 %) and HR-CT of the lung.Conclusion:The study highlighted that a reduced DLCO in lung function test is associated with a lung involvement in IRD. DLCO represented a potential screening parameter for lung manifestation in IRD. Especially patients with suspected vasculitis should receive an additional chest x-ray. Based on the high sensitivity of DLCO in combination with chest x-ray or HR-CT for the detection of ILD in IRD, all patients with a reduced DLCO (< 80%) should obtained an imaging of the lung.Disclosure of Interests:None declared

Download Full-text

COVID 19, Pneumonia and Other Disease Classification using Chest X-Ray images

2021 2nd International Conference for Emerging Technology (INCET) ◽

10.1109/incet51464.2021.9456192 ◽

2021 ◽

Author(s):

Abhishek Panwar ◽

Akshay Dagar ◽

Vishal Pal ◽

Vinod Kumar

Keyword(s):

Disease Classification ◽

X Ray ◽

Chest X Ray

Download Full-text

Ventilator-associated pneumonia in neonates: the role of point of care lung ultrasound

European Journal of Pediatrics ◽

10.1007/s00431-020-03710-8 ◽

2020 ◽

Vol 180 (1) ◽

pp. 137-146

Author(s):

Nora Tusor ◽

Angela De Cunto ◽

Yousef Basma ◽

John L. Klein ◽

Virginie Meau-Petit

Keyword(s):

Lung Disease ◽

Chronic Lung Disease ◽

Lung Ultrasound ◽

Clinical Laboratory ◽

Control Group ◽

Ventilator Associated Pneumonia ◽

Lung Pathology ◽

Rater Agreement ◽

X Ray ◽

Chest X Ray

AbstractNo consensus exists regarding the definition of ventilator-associated pneumonia (VAP) in neonates and reliability of chest X-ray (CXR) is low. Lung ultrasound (LU) is a potential alternative diagnostic tool. The aim was to define characteristics of VAP in our patient population and propose a multiparameter score, incorporating LU, for VAP diagnosis. Between March 25, 2018, and May 25, 2019, infants with VAP were identified. Clinical, laboratory and microbiology data were collected. CXRs and LU scans were reviewed. A multiparameter VAP score, including LU, was calculated on Day 1 and Day 3 for infants with VAP and for a control group and compared with CXR. VAP incidence was 10.47 episodes/1000 ventilator days. LU and CXR were available for 31 episodes in 21 infants with VAP, and for six episodes in five patients without VAP. On Day 1, a VAP score of > 4, and on Day 3 a score of > 5 showed sensitivity of 0.94, and area under the curve of 0.91 and 0.97, respectively. AUC for clinical information only was 0.88 and for clinical and CXR 0.85.Conclusion: The multiparameter VAP score including LU could be useful in diagnosing VAP in neonates with underlying lung pathology. What is Known:• Ventilator associated pneumonia (VAP) is common in infants on the neonatal unit and is associated with increased use of antibiotics, prolonged ventilation and higher incidence of chronic lung disease.• Commonly used definitions of VAP are difficult to apply in neonates and interpretation of chest X-ray is challenging with poor inter-rater agreement in patients with underlying chronic lung disease. What is New:• The multiparameter VAP score combining clinical, microbiology and lung ultrasound (LU) data is predictive for VAP diagnosis in preterm infants with chronic lung disease.• LU findings of VAP in neonates showed high inter-rater agreement and included consolidated lung areas, dynamic bronchograms and pleural effusion.

Download Full-text

SDFN: Segmentation-based deep fusion network for thoracic disease classification in chest X-ray images

Computerized Medical Imaging and Graphics ◽

10.1016/j.compmedimag.2019.05.005 ◽

2019 ◽

Vol 75 ◽

pp. 66-73 ◽

Cited By ~ 9

Author(s):

Han Liu ◽

Lei Wang ◽

Yandong Nan ◽

Faguang Jin ◽

Qi Wang ◽

...

Keyword(s):

Disease Classification ◽

Thoracic Disease ◽

X Ray ◽

Chest X Ray

Download Full-text

Interstitial lung disease: A case report

Medicine Today ◽

10.3329/medtoday.v24i1.14118 ◽

2013 ◽

Vol 24 (1) ◽

pp. 52-54

Author(s):

SM Kamal ◽

Md Abu Bakar ◽

MA Ahad

Keyword(s):

Case Report ◽

Interstitial Lung Disease ◽

Idiopathic Pulmonary Fibrosis ◽

Lung Disease ◽

Rare Case ◽

Productive Cough ◽

X Ray ◽

Chest Examination ◽

Chest X Ray ◽

Medicine Today

A 65 years old farmer was admitted in Medicine ward with the complaints of progressive exertional breathlessness, non-productive cough and recurrent episodes of fever. The patient had clubbing and chest examination revealed end inspiratory crackles. Chest x-ray, CT scan of chest and spirometry revealed the features of interstitial lung disease (ILD). So we diagnosed the case as idiopathic pulmonary fibrosis variety of ILD. We reported this rare case for developing awareness among the clinicians. DOI: http://dx.doi.org/10.3329/medtoday.v24i1.14118 Medicine TODAY Vol.24(1) 2012 pp.52-54

Download Full-text

IgG4-related lung disease on the horizon

Hong Kong Bulletin on Rheumatic Diseases ◽

10.1515/hkbrd-2018-0002 ◽

2018 ◽

Vol 0 (0) ◽

Author(s):

Tin Lok Lai ◽

Cheuk Wan Yim

Keyword(s):

Lung Disease ◽

Lung Biopsy ◽

Lung Nodules ◽

Lung Involvement ◽

Immunoglobulin G4 ◽

X Ray ◽

Related Disease ◽

Igg4 Related Disease ◽

Chest X Ray ◽

Diffuse Lung

Abstract Immunoglobulin G4 (IgG4) related lung disease is an emerging entity. We report a case of a 42-year-old man presented with fever and cough with minimal sputum. Chest X-ray revealed diffuse reticulonodular shadows. Extensive investigations were performed, including video-assisted thoracoscopic lung biopsy, which confirmed the diagnosis of IgG4-related disease (IgG4-RD) with lung involvement. This case report aims to illustrate that IgG4-related lung involvement can present as diffuse lung nodules and can affect different pulmonary structures. IgG4-RD should always be considered when a similar scenario is encountered.

Download Full-text

Amiodarone-Induced Pulmonary Toxicity – A Frequently Missed Complication

Clinical Medicine Insights Case Reports ◽

10.4137/ccrep.s39809 ◽

2016 ◽

Vol 9 ◽

pp. CCRep.S39809 ◽

Cited By ~ 8

Author(s):

Alexander J. Sweidan ◽

Navneet K. Singh ◽

Natasha Dang ◽

Vinh Lam ◽

Jyoti Datta

Keyword(s):

Coronary Artery ◽

Lung Disease ◽

Interstitial Pneumonitis ◽

Pulmonary Toxicity ◽

Pulmonary Nodules ◽

Ground Glass ◽

X Rays ◽

X Ray ◽

Chest X Ray ◽

New Onset

Introduction Amiodarone is often used in the suppression of tachyarrhythmias. One of the more serious adverse effects includes amiodarone pulmonary toxicity (APT). Several pulmonary diseases can manifest including interstitial pneumonitis, organizing pneumonia, acute respiratory distress syndrome, diffuse alveolar hemorrhage, pulmonary nodules or masses, and pleural effusion. Incidence of APT varies from 5–15% and is correlated to dosage, age of the patient, and preexisting lung disease. Description A 56-year-old male with a past medical history of coronary artery disease and chronic obstructive pulmonary disease was admitted for a coronary artery bypass graft. Post-operatively, the patient was admitted to the ICU for ventilator management and continued to receive his home dose of amiodarone 400 mg orally twice daily, which he had been taking for the past 3 months. The patient was found to be hypoxemic with a PaO2 52 mmHg and bilateral infiltrates on chest x-ray. Patient also complained of new onset dyspnea. Physical exam found bilateral rhonchi with bibasilar crackles and subcutaneous emphysema along the left anterior chest wall. Daily chest x-rays showed worsening of bilateral interstitial infiltrates and pleural effusions. A chest high-resolution computed tomography on post-operative day 3 showed extensive and severe bilateral ground glass opacities. APT was suspected and amiodarone was discontinued. A course of oral prednisone without antibiotics was initiated, and after one week of treatment the chest film cleared, the PaO2 value normalized and dyspnea resolved. Discussion APT occurs via cytotoxic T cells and indirectly by immunological reaction. Typically the lungs manifest a diffuse interstitial pneumonitis with varying degrees of fibrosis. Infiltrates with a ‘ground-glass’ appearance appreciated on HRCT are more definitive than chest x-ray. Pulmonary nodules can be seen, frequently in the upper lobes. These are postulated to be accumulations of amiodarone in areas of previous inflammation. Those undergoing major cardiothoracic surgery are known to be predisposed to APT. Some elements require consideration: a baseline pulmonary function test (PFT) did not exist prior. APT would manifest a restrictive pattern of PFTs. In APT diffusing capacity (DLCO) is generally >20 percent from baseline. A DLCO was not done in this patient. Therefore, not every type of interstitial lung disease could be ruled out. Key features support a clinical diagnosis: (1) new dyspnea, (2) exclusion of lung infection, (3) exclusion of heart failure, (4) new radiographic features, (5) improvement with withdrawal of amiodarone. Our case illustrates consideration of APT in patients who have extensive use of amiodarone and new onset dyspnea.

Download Full-text

Design and Development of Lung Disease and Damage Analyzer

International Journal of Advanced Research in Science, Communication and Technology ◽

10.48175/ijarsct-v4-i3-025 ◽

2021 ◽

pp. 160-164

Author(s):

Ram Haridas ◽

Yash Agrawal ◽

Yash Chopra ◽

Nimish Khedkar ◽

Dhawal Patil ◽

...

Keyword(s):

Computer Vision ◽

Lung Disease ◽

Medical Field ◽

Design And Development ◽

X Ray ◽

Chest X Ray

Chest X-ray are generated in less time but report based on chest X-ray takes time which is not feasible during the pandemic situations like Covid-19 as delay in report can cause severe consequences. As a result, it is observed that ML can help in medical field to reduce the time to generate a report. With the help of ML and Computer Vision models can be built that can be used to predict Lungs Cancer as well as various diseases of Lungs and not only this several models have been created that are helping in predictions of various ailment as well as fractures. Using ML and Computer Vision can create models that once trained properly can give accurate predictions and that too in less time. In medical field time taken to generate report is very crucial as in some situations it becomes the matter of time for a patient to survive.

Download Full-text