This chapter assesses energy, water, and food resource systems based on their inter- and intra-sectoral imperatives of large scale development investments at the institutional level (including private and public activities) and how to achieve security of resource supplies. It identifies key interrelated processes, practices, and factors that underpin integrated resource management (IRM) and their attendant benefits. Applying the E4 framework concerned with energy, economy, environment, and equity to identify the main threats to these systems, the chapter evaluates their institutional, political, economic, cultural and behavioral components, and characterizes the forces that drive each of them at different governance scales. The chapter is guided by political economy, economic, and sociological theories that suggest that institutional structures affect economic factors and processes (i.e. production, distribution, and consumption processes). A case study of energy, water, and food (EWF) conflicting sectoral imperatives in Delaware is discussed in detail to better understand how these policy and institutional processes occur, which forms they take, and in which ways they define the quality and quantity of EWF resource systems in the State. In order to verify these parameters, the analysis considered the advantages of a sectorally balanced, E4 framework, in particular to evaluate the valency and magnitude of cross-sectoral connections, balance competing needs, and identify policy options that address various trade-offs.