Mea-On-Cantilever – A Novel Multifunctional Device for Drug Toxicity Screening in Cardiomyocytes

2021 ◽  
Author(s):  
Pooja P. Kanade ◽  
Nomin-Erdene Oyunbaatar ◽  
Yun-Jin Jeong ◽  
Dong-Weon Lee
Keyword(s):  
Drug Toxicity ◽  
Toxicity Screening ◽  
Multifunctional Device

Enhanced Hepatic Functions of Genetically Modified Mouse Hepatoma Cells by Spheroid Culture for Drug Toxicity Screening

2017 ◽  
Vol 12 (10) ◽  
pp. 1700274 ◽  
Author(s):  
Joyita Sarkar ◽  
Jyoti Kumari ◽  
Jane M. Tonello ◽  
Masamichi Kamihira ◽  
Ashok Kumar
Keyword(s):  
Drug Toxicity ◽  
Genetically Modified ◽  
Hepatoma Cells ◽  
Toxicity Screening ◽  
Spheroid Culture ◽  
Mouse Hepatoma

scholarly journals Critical Considerations for the Design of Multi-Organ Microphysiological Systems (MPS)

2021 ◽  
Vol 9 ◽  
Author(s):  
Mridu Malik ◽  
Yang Yang ◽  
Parinaz Fathi ◽  
Gretchen J. Mahler ◽  
Mandy B. Esch
Keyword(s):  
Animal Models ◽  
Drug Toxicity ◽  
New Drugs ◽  
Drug Candidate ◽  
Preclinical Studies ◽  
Toxicity Screening ◽  
Drug Candidates ◽  
Microphysiological Systems

Identification and approval of new drugs for use in patients requires extensive preclinical studies and clinical trials. Preclinical studies rely on in vitro experiments and animal models of human diseases. The transferability of drug toxicity and efficacy estimates to humans from animal models is being called into question. Subsequent clinical studies often reveal lower than expected efficacy and higher drug toxicity in humans than that seen in animal models. Microphysiological systems (MPS), sometimes called organ or human-on-chip models, present a potential alternative to animal-based models used for drug toxicity screening. This review discusses multi-organ MPS that can be used to model diseases and test the efficacy and safety of drug candidates. The translation of an in vivo environment to an in vitro system requires physiologically relevant organ scaling, vascular dimensions, and appropriate flow rates. Even small changes in those parameters can alter the outcome of experiments conducted with MPS. With many MPS devices being developed, we have outlined some established standards for designing MPS devices and described techniques to validate the devices. A physiologically realistic mimic of the human body can help determine the dose response and toxicity effects of a new drug candidate with higher predictive power.

Environmental Toxicology Assays Using Organ-on-Chip

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Patarajarin Akarapipad ◽  
Kattika Kaarj ◽  
Yan Liang ◽  
Jeong-Yeol Yoon
Keyword(s):  
Drug Toxicity ◽  
Environmental Toxicology ◽  
In Vitro Assays ◽  
Annual Review ◽  
Publication Date ◽  
Environmental Toxicants ◽  
Toxicity Screening ◽  
On Chip

Adverse effects of environmental toxicants to human health have traditionally been assayed using in vitro assays. Organ-on-chip (OOC) is a new platform that can bridge the gaps between in vitro assays (or 3D cell culture) and animal tests. Microenvironments, physical and biochemical stimuli, and adequate sensing and biosensing systems can be integrated into OOC devices to better recapitulate the in vivo tissue and organ behavior and metabolism. While OOCs have extensively been studied for drug toxicity screening, their implementation in environmental toxicology assays is minimal and has limitations. In this review, recent attempts of environmental toxicology assays using OOCs, including multiple-organs-on-chip, are summarized and compared with OOC-based drug toxicity screening. Requirements for further improvements are identified and potential solutions are suggested. Expected final online publication date for the Annual Review of Analytical Chemistry, Volume 14 is August 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Engineering a functional three-dimensional human cardiac tissue model for drug toxicity screening

2017 ◽  
Vol 9 (2) ◽  
pp. 025011 ◽  
Author(s):  
Hong Fang Lu ◽  
Meng Fatt Leong ◽  
Tze Chiun Lim ◽  
Ying Ping Chua ◽  
Jia Kai Lim ◽  
...  
Keyword(s):  
Drug Toxicity ◽  
Cardiac Tissue ◽  
Three Dimensional ◽  
Toxicity Screening ◽  
Tissue Model ◽  
Human Cardiac Tissue

Zebrafish for drug toxicity screening: bridging thein vitrocell-based models andin vivomammalian models

2011 ◽  
Vol 7 (5) ◽  
pp. 579-589 ◽  
Author(s):  
Hendrian Sukardi ◽  
Hui Ting Chng ◽  
Eric Chun Yong Chan ◽  
Zhiyuan Gong ◽  
Siew Hong Lam
Keyword(s):  
Drug Toxicity ◽  
Toxicity Screening

Development of high-throughput liver-on-a-chip for drug toxicity screening

2018 ◽  
Vol 295 ◽  
pp. S111-S112
Author(s):  
K. Wilschut ◽  
R.J. Annida ◽  
Z. Wang ◽  
C. Ng ◽  
V. Shevchenko ◽  
...  
Keyword(s):  
High Throughput ◽  
Drug Toxicity ◽  
Toxicity Screening
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