High frequency shift in Carotid Sinus Nerve and Sympathetic Nerve activity in Type 2 Diabetic Rat Model*

2019 ◽  
Author(s):  
Marina Cracchiolo ◽  
Joana F. Sacramento ◽  
Alberto Mazzoni ◽  
Alessandro Panarese ◽  
Jacopo Carpaneto ◽  
...  
Keyword(s):  
High Frequency ◽  
Sympathetic Nerve Activity ◽  
Carotid Sinus ◽  
Diabetic Rat ◽  
Carotid Sinus Nerve ◽  
Nerve Activity ◽  
High Frequency Shift ◽  
Diabetic Rat Model ◽  
Type 2 Diabetic

SGLT-2 Inhibition: Novel Therapeutics for Reno-and Cardioprotection in Diabetes Mellitus

2019 ◽  
Vol 15 (5) ◽  
pp. 349-356 ◽  
Author(s):  
Angus Gill ◽  
Stephen P. Gray ◽  
Karin A. Jandeleit-Dahm ◽  
Anna M.D. Watson
Keyword(s):  
Sympathetic Nerve Activity ◽  
Diabetic Patients ◽  
Protective Effects ◽  
Preclinical Research ◽  
Type 2 Diabetic Patients ◽  
Nerve Activity ◽  
Current State ◽  
Glucose Reabsorption ◽  
Type 2 Diabetic

Background: The sodium glucose co-transporter 2 (SGLT2) is primarily located within S1 of the renal proximal tubule being responsible for approximately 90% of glucose re-uptake in the kidney. Inhibition of SGLT2 is an exciting new pharmacological approach for the reduction of blood glucose in type 2 diabetic patients via inhibition of tubular glucose reabsorption. In addition to lowering glucose, this group of drugs has shown significant cardiovascular and renal protective effects. Conclusion: This review aims to outline the current state of preclinical research and clinical trials for different SGLT2 inhibitors and outline some of the proposed mechanisms of action, including possible effects on sympathetic nerve activity, which may contribute to the unexpected beneficial cardiovascular and reno-protective effects of this class of compounds.

scholarly journals COMP-Angiopoietin-1 Promotes Cavernous Angiogenesis in a Type 2 Diabetic Rat Model

2013 ◽  
Vol 28 (5) ◽  
pp. 725 ◽  
Author(s):  
Sun-Ouck Kim ◽  
Hyun-Suk Lee ◽  
Kyuyoun Ahn ◽  
Kwangsung Park
Keyword(s):  
Rat Model ◽  
Diabetic Rat ◽  
Diabetic Rat Model ◽  
Type 2 Diabetic ◽  
Angiopoietin 1

The Effect of α-Lipoic Acid on Proteinuria and Renal TGFβ Expression in Obese Type 2 Diabetic Rat Model

2008 ◽  
Vol 32 (1) ◽  
pp. 21
Author(s):  
Seok Woo Kang ◽  
Seong Jin Lee ◽  
Dong-Sun Kim ◽  
Tae Wha Kim
Keyword(s):  
Lipoic Acid ◽  
Rat Model ◽  
Diabetic Rat ◽  
Diabetic Rat Model ◽  
Type 2 Diabetic

scholarly journals Effects of liraglutide on heart function and myocardial perfusion entropy in a type-2 diabetic rat model

2020 ◽  
Vol 12 (2-4) ◽  
pp. 212
Author(s):  
M. Canu ◽  
A. Carabelli ◽  
M. Debiossat ◽  
A. Broisat ◽  
M. Desvignes ◽  
...  
Keyword(s):  
Myocardial Perfusion ◽  
Rat Model ◽  
Heart Function ◽  
Diabetic Rat ◽  
Diabetic Rat Model ◽  
Type 2 Diabetic

scholarly journals Dapagliflozin Modulates the Fecal Microbiota in a Type 2 Diabetic Rat Model

2020 ◽  
Vol 11 ◽  
Author(s):  
Mei Yang ◽  
Fang-Hong Shi ◽  
Wen Liu ◽  
Min-Chun Zhang ◽  
Ri-Lu Feng ◽  
...  
Keyword(s):  
Rat Model ◽  
Fecal Microbiota ◽  
Diabetic Rat ◽  
Diabetic Rat Model ◽  
Type 2 Diabetic
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