scholarly journals Design of high sensitivity, high resolution compact single photon imaging devices for small animal and dedicated breast imaging

2005 ◽  
Author(s):  
M.F. Smith ◽  
S. Majewski ◽  
S.R. Meikle ◽  
A.G. Weisenberger ◽  
V. Popov ◽  
...  
Keyword(s):  
High Resolution ◽  
Breast Imaging ◽  
Single Photon ◽  
Small Animal ◽  
High Sensitivity ◽  
Photon Imaging

scholarly journals Performance Evaluation of Fifth-Generation Ultra-High-Resolution SPECT System with Two Stationary Detectors and Multi-Pinhole Imaging

2020 ◽  
Author(s):  
Jan V Hoffmann ◽  
Jan P Janssen ◽  
Takayuki Kanno ◽  
Takayuki Shibutani ◽  
Masahisa Onoguchi ◽  
...  
Keyword(s):  
High Resolution ◽  
Spatial Resolution ◽  
Single Photon ◽  
Photon Emission ◽  
Small Animal ◽  
High Sensitivity ◽  
General Purpose ◽  
Emission Computed Tomography ◽  
High Count ◽  
Spect System

Abstract Background: Small-animal single-photon emission computed tomography (SPECT) systems with multi-pinhole collimation and large stationary detectors have advantages compared to systems with moving small detectors. These systems benefit from less labour-intensive maintenance and quality control as fewer prone parts are moving, higher accuracy for focused scans and maintaining high resolution with increased sensitivity due to focused pinholes on the field of view. This study aims to investigate the performance of a novel ultra-high-resolution scanner with two-detector-configuration (U-SPECT5-E) and to compare its image quality to a conventional micro-SPECT system with three stationary detectors (U-SPECT+).Methods: The new U-SPECT5-E with two stationary detectors was used for acquiring data with 99mTc-filled point source, hot-rod and uniformity phantoms to analyse sensitivity, spatial resolution, uniformity and contrast-to-noise ratio (CNR). Three dedicated multi-pinhole mouse collimators with 75 pinholes each and 0.25-, 0.60- and 1.00-mm pinholes for extra ultra-high resolution (XUHR-M), general-purpose (GP-M) and ultra-high sensitivity (UHS-M) imaging were examined. For CNR analysis, four different activity ranges representing low- and high-count settings were investigated for all three collimators. The experiments for the performance assessment were repeated with the same GP-M collimator in the three-detector U-SPECT+ for comparison. Results: Peak sensitivity was 237 cps/MBq (XUHR-M), 847 cps/MBq (GP-M), 2054 cps/MBq (UHS-M) for U-SPECT5-E and 1710 cps/MBq (GP-M) for U-SPECT+. In the visually analysed sections of the reconstructed mini Derenzo phantom, rods as small as 0.35 mm (XUHR-M), 0.50 mm (GP-M) for the two-detector as well as the three-detector SPECT and 0.75 mm (UHS-M) were resolved. Uniformity for maximum resolution recorded 40.7% (XUHR-M), 29.1% (GP-M, U-SPECT5-E), 16.3% (GP-M, U-SPECT+) and 23.0% (UHS-M), respectively. UHS-M reached highest CNR values for low-count images; for rods smaller than 0.45 mm, acceptable CNR was only achieved by XUHR-M. GP-M was superior for imaging rods sized from 0.60-1.50 mm for intermediate activity concentrations. U-SPECT5-E and U-SPECT+ both provided comparable CNR.Conclusions: While uniformity and sensitivity are negatively affected by the absence of a third detector, the investigated U-SPECT5-E system with two stationary detectors delivers excellent spatial resolution and CNR comparable to the performance of an established three-detector-setup.

scholarly journals Un-collimated single-photon imaging system for high-sensitivity small animal and plant imaging

2014 ◽  
Vol 60 (1) ◽  
pp. 403-420 ◽  
Author(s):  
Katherine L Walker ◽  
Martin S Judenhofer ◽  
Simon R Cherry ◽  
Gregory S Mitchell
Keyword(s):  
Imaging System ◽  
Single Photon ◽  
Small Animal ◽  
High Sensitivity ◽  
Photon Imaging

scholarly journals SPEM: a state-of-the-art instrument for high resolution molecular imaging of small animal organs

2012 ◽  
Vol 10 (2) ◽  
pp. 209-215 ◽  
Author(s):  
Marilia Alves dos Reis ◽  
Jorge Mejia ◽  
Ilza Rosa Batista ◽  
Marycel Rosa Felisa Figols de Barboza ◽  
Solange Amorim Nogueira ◽  
...  
Keyword(s):  
High Resolution ◽  
State Of The Art ◽  
Single Photon ◽  
Photon Emission ◽  
Small Animal ◽  
Software Tool ◽  
High Sensitivity ◽  
Spect Imaging ◽  
Innovative Technology ◽  
Animal Organs

OBJECTIVE: To describe the Single Photon Emission Microscope (SPEM), a state-of-the-art instrument for small animal SPECT imaging, and characterize its performance presenting typical images of different animal organs. METHODS: SPEM consists of two independent imaging devices based on high resolution scintillators, high sensitivity and resolution Electron-Multiplying CCDs and multi-pinhole collimators. During image acquisition, the mouse is placed in a rotational vertical holder between the imaging devices. Subsequently, an appropriate software tool based on the Maximum Likelihood algorithm iteratively produces the volumetric image. Radiopharmaceuticals for imaging kidneys, heart, thyroid and brain were used. The mice were injected with 74 to 148 MBq/0,3mL and scanned for 40 to 80 minutes, 30 to 60 minutes afterwards. During this procedure, the animals remained under ketamine/xilazine anesthesia. RESULTS: SPEM images of different mouse organs are presented, attesting the imaging capabilities of the instrument. CONCLUSION: SPEM is an innovative technology for small animal SPECT imaging providing high resolution images with appropriate sensitivity for pre-clinical research. Its use with appropriate radiotracers will allow translational investigation of several animal models of human diseases, their pharmacological treatment and the development of potential new therapeutic agents.

scholarly journals Performance evaluation of fifth-generation ultra-high-resolution SPECT system with two stationary detectors and multi-pinhole imaging

2020 ◽  
Vol 7 (1) ◽  
Author(s):  
Jan V. Hoffmann ◽  
Jan P. Janssen ◽  
Takayuki Kanno ◽  
Takayuki Shibutani ◽  
Masahisa Onoguchi ◽  
...  
Keyword(s):  
High Resolution ◽  
Spatial Resolution ◽  
Single Photon ◽  
Photon Emission ◽  
Small Animal ◽  
High Sensitivity ◽  
General Purpose ◽  
Emission Computed Tomography ◽  
High Count ◽  
Spect System

Abstract Background Small-animal single-photon emission computed tomography (SPECT) systems with multi-pinhole collimation and large stationary detectors have advantages compared to systems with moving small detectors. These systems benefit from less labour-intensive maintenance and quality control as fewer prone parts are moving, higher accuracy for focused scans and maintaining high resolution with increased sensitivity due to focused pinholes on the field of view. This study aims to investigate the performance of a novel ultra-high-resolution scanner with two-detector configuration (U-SPECT5-E) and to compare its image quality to a conventional micro-SPECT system with three stationary detectors (U-SPECT+). Methods The new U-SPECT5-E with two stationary detectors was used for acquiring data with 99mTc-filled point source, hot-rod and uniformity phantoms to analyse sensitivity, spatial resolution, uniformity and contrast-to-noise ratio (CNR). Three dedicated multi-pinhole mouse collimators with 75 pinholes each and 0.25-, 0.60- and 1.00-mm pinholes for extra ultra-high resolution (XUHR-M), general-purpose (GP-M) and ultra-high sensitivity (UHS-M) imaging were examined. For CNR analysis, four different activity ranges representing low- and high-count settings were investigated for all three collimators. The experiments for the performance assessment were repeated with the same GP-M collimator in the three-detector U-SPECT+ for comparison. Results Peak sensitivity was 237 cps/MBq (XUHR-M), 847 cps/MBq (GP-M), 2054 cps/MBq (UHS-M) for U-SPECT5-E and 1710 cps/MBq (GP-M) for U-SPECT+. In the visually analysed sections of the reconstructed mini Derenzo phantoms, rods as small as 0.35 mm (XUHR-M), 0.50 mm (GP-M) for the two-detector as well as the three-detector SPECT and 0.75 mm (UHS-M) were resolved. Uniformity for maximum resolution recorded 40.7% (XUHR-M), 29.1% (GP-M, U-SPECT5-E), 16.3% (GP-M, U-SPECT+) and 23.0% (UHS-M), respectively. UHS-M reached highest CNR values for low-count images; for rods smaller than 0.45 mm, acceptable CNR was only achieved by XUHR-M. GP-M was superior for imaging rods sized from 0.60 to 1.50 mm for intermediate activity concentrations. U-SPECT5-E and U-SPECT+ both provided comparable CNR. Conclusions While uniformity and sensitivity are negatively affected by the absence of a third detector, the investigated U-SPECT5-E system with two stationary detectors delivers excellent spatial resolution and CNR comparable to the performance of an established three-detector-setup.

scholarly journals Performance Evaluation of Fifth-generation Ultra-high-resolution Spect System With Two Stationary Detectors and Multi-pinhole Imaging

2020 ◽  
Author(s):  
Jan V Hoffmann ◽  
Jan P Janssen ◽  
Takayuki Kanno ◽  
Takayuki Shibutani ◽  
Masahisa Onoguchi ◽  
...  
Keyword(s):  
High Resolution ◽  
Spatial Resolution ◽  
Single Photon ◽  
Photon Emission ◽  
Small Animal ◽  
High Sensitivity ◽  
Emission Computed Tomography ◽  
High Count ◽  
Comparison Results ◽  
Spect System

Abstract Purpose Small-animal single-photon emission computed tomography (SPECT) systems with multi-pinhole collimation and large stationary detectors have advantages compared to systems with moving small detectors. This study aims to investigate the performance of a novel ultra-high-resolution scanner with two-detector-configuration (U-SPECT5-E) and to compare its image quality to a conventional micro-SPECT system with three stationary detectors (U-SPECT+). Methods The new U-SPECT5-E with two stationary detectors was used for acquiring data with 99mTc-filled point source, hot-rod and uniformity phantoms to analyse sensitivity, spatial resolution, uniformity and contrast-to-noise ratio (CNR). Three dedicated multi-pinhole mouse collimators with 75 pinholes each and 0.25-, 0.60- and 1.00-mm pinholes for extra ultra-high resolution (XUHR-M), general-purpose (GP-M) and ultra-high sensitivity (UHS-M) imaging were examined. For CNR analysis, four different activity ranges representing low- and high-count settings were investigated for all three collimators. The experiments for the performance assessment were repeated with the same GP-M collimator in the three-detector U-SPECT+ for comparison. Results Peak sensitivity was 237 cps/MBq (XUHR-M), 847 cps/MBq (GP-M), 2054 cps/MBq (UHS-M) for U-SPECT5-E and 1710 cps/MBq (GP-M) for U-SPECT+. Resolution in the visually analysed sections of the reconstructed hot-rod phantom was 0.35 mm (XUHR-M), 0.50 mm (GP-M) for the two-detector as well as the three-detector SPECT and 0.75 mm (UHS-M). Uniformity for maximum resolution recorded 40.7% (XUHR-M), 29.1% (GP-M, U-SPECT5-E), 16.3% (GP-M, U-SPECT+) and 23.0% (UHS-M), respectively. UHS-M reached highest CNR values for low-count images; for rods smaller than 0.45 mm, acceptable CNR was only achieved by XUHR-M. GP-M was superior for imaging rods sized from 0.60–1.50 mm for intermediate activity concentrations. U-SPECT5-E and U-SPECT+ both provided comparable CNR. Conclusions While uniformity and sensitivity are negatively affected by the absence of a third detector, the investigated U-SPECT5-E system with two stationary detectors delivers excellent spatial resolution and CNR comparable to the performance of an established three-detector-setup.

Detector Performance Characterization for High Sensitivity Single-Photon Imaging

2014 ◽  
Vol 61 (3) ◽  
pp. 1118-1125 ◽  
Author(s):  
Katherine L. Walker ◽  
Simon R. Cherry ◽  
Gregory S. Mitchell
Keyword(s):  
Single Photon ◽  
High Sensitivity ◽  
Detector Performance ◽  
Performance Characterization ◽  
Photon Imaging

scholarly journals Robust real-time 3D imaging of moving scenes through atmospheric obscurant using single-photon LiDAR

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Rachael Tobin ◽  
Abderrahim Halimi ◽  
Aongus McCarthy ◽  
Philip J. Soan ◽  
Gerald S. Buller
Keyword(s):  
High Resolution ◽  
Real Time ◽  
Moving Objects ◽  
Single Photon ◽  
Three Dimensional ◽  
Depth Profiling ◽  
High Sensitivity ◽  
Single Photon Detection ◽  
Photon Detection ◽  
Uncertainty Estimates

AbstractRecently, time-of-flight LiDAR using the single-photon detection approach has emerged as a potential solution for three-dimensional imaging in challenging measurement scenarios, such as over distances of many kilometres. The high sensitivity and picosecond timing resolution afforded by single-photon detection offers high-resolution depth profiling of remote, complex scenes while maintaining low power optical illumination. These properties are ideal for imaging in highly scattering environments such as through atmospheric obscurants, for example fog and smoke. In this paper we present the reconstruction of depth profiles of moving objects through high levels of obscurant equivalent to five attenuation lengths between transceiver and target at stand-off distances up to 150 m. We used a robust statistically based processing algorithm designed for the real time reconstruction of single-photon data obtained in the presence of atmospheric obscurant, including providing uncertainty estimates in the depth reconstruction. This demonstration of real-time 3D reconstruction of moving scenes points a way forward for high-resolution imaging from mobile platforms in degraded visual environments.

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