Development of a Triple Modality Small Animal Planar Imaging System

Abstract A surface radio frequency coil was developed for small animal image acquisition in a pre-clinical magnetic resonance imaging system at 7 T. A flexible coil composed of two circular loops was developed to closely cover the object to be imaged. Electromagnetic numerical simulations were performed to evaluate its performance before the coil construction. An analytical expression of the mutual inductance for the two circular loops as a function of the separation between them was derived and used to validate the simulations. The RF coil is composed of two circular loops with a 5 cm external diameter and was tuned to 300 MHz and 50 Ohms matched. The angle between the loops was varied and the Q factor was obtained from the S11 simulations for each angle. B1 homogeneity was also evaluated using the electromagnetic simulations. The coil prototype was designed and built considering the numerical simulation results. To show the feasibility of the coil and its performance, saline-solution phantom images were acquired. A correlation of the simulations and imaging experimental results was conducted showing a concordance of 0.88 for the B1 field. The best coil performance was obtained at the 90° aperture angle. A more realistic phantom was also built using a formaldehyde-fixed rat phantom for ex vivo imaging experiments. All images showed a good image quality revealing clearly defined anatomical details of an ex vivo rat.

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SemiSPECT: a small-animal imaging system based on eight CdZnTe pixel detectors

2002 IEEE Nuclear Science Symposium Conference Record ◽

10.1109/nssmic.2002.1239682 ◽

2004 ◽

Cited By ~ 6

Author(s):

T.F. Peterson ◽

Hyunki Kim ◽

M.J. Crawford ◽

B.M. Gershman ◽

W.C.J. Hunter ◽

...

Keyword(s):

Imaging System ◽

Small Animal Imaging ◽

Small Animal ◽

Pixel Detectors ◽

Animal Imaging

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Tri-modality small animal imaging system

IEEE Symposium Conference Record Nuclear Science 2004. ◽

10.1109/nssmic.2004.1466722 ◽

2005 ◽

Cited By ~ 2

Author(s):

B.K. Kundu ◽

A.V. Stolin ◽

J. Pole ◽

L. Baumgart ◽

M. Fontaine ◽

...

Keyword(s):

Imaging System ◽

Small Animal Imaging ◽

Small Animal ◽

Animal Imaging

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Study of Image Qualities From 6D Robot–Based CBCT Imaging System of Small Animal Irradiator

Technology in Cancer Research & Treatment ◽

10.1177/1533034617700558 ◽

2017 ◽

Vol 16 (6) ◽

pp. 811-818 ◽

Cited By ~ 1

Author(s):

Sunil Sharma ◽

Ganesh Narayanasamy ◽

Richard Clarkson ◽

Ming Chao ◽

Eduardo G. Moros ◽

...

Keyword(s):

Imaging System ◽

Small Animal

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In Vivo Imaging of Peripheral Benzodiazepine Receptors in Mouse Lungs: A Biomarker of Inflammation

Molecular Imaging ◽

10.2310/7290.2005.05133 ◽

2005 ◽

Vol 4 (4) ◽

pp. 7290.2005.05133 ◽

Cited By ~ 19

Author(s):

Matthew J. Hardwick ◽

Ming-Kai Chen ◽

Kwamena Baidoo ◽

Martin G. Pomper ◽

Tomás R. Guilarte

Keyword(s):

In Vivo Imaging ◽

Ex Vivo ◽

Inflammatory Diseases ◽

Imaging Techniques ◽

Benzodiazepine Receptors ◽

Small Animal ◽

Small Animal Pet ◽

Planar Imaging ◽

Peripheral Benzodiazepine Receptors

The ability to visualize the immune response with radioligands targeted to immune cells will enhance our understanding of cellular responses in inflammatory diseases. Peripheral benzodiazepine receptors (PBR) are present in monocytes and neutrophils as well as in lung tissue. We used lipopolysaccharide (LPS) as a model of inflammation to assess whether the PBR could be used as a noninvasive marker of inflammation in the lungs. Planar imaging of mice administrated 10 or 30 mg/kg LPS showed increased [123I]-( R)-PK11195 radioactivity in the thorax 2 days after LPS treatment relative to control. Following imaging, lungs from control and LPS-treated mice were harvested for ex vivo gamma counting and showed significantly increased radioactivity above control levels. The specificity of the PBR response was determined using a blocking dose of nonradioactive PK11195 given 30 min prior to radiotracer injection. Static planar images of the thorax of nonradioactive PK11195 pretreated animals showed a significantly lower level of radiotracer accumulation in control and in LPS-treated animals ( p < .05). These data show that LPS induces specific increases in PBR ligand binding in the lungs. We also used in vivo small-animal PET studies to demonstrate increased [11C]-( R)-PK11195 accumulation in the lungs of LPS-treated mice. This study suggests that measuring PBR expression using in vivo imaging techniques may be a useful biomarker to image lung inflammation.

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Element-level Phase Measurement of Array Antenna using Stabilized Planar Imaging System for Emerging Sub-6 GHz 5G Communications

2019 IEEE Asia-Pacific Microwave Conference (APMC) ◽

10.1109/apmc46564.2019.9038272 ◽

2019 ◽

Author(s):

Young-Pyo Hong ◽

Kyungho Yoo ◽

Tongho Chung ◽

Byungchul Kim ◽

No-Weon Kang ◽

...

Keyword(s):

Imaging System ◽

Phase Measurement ◽

Array Antenna ◽

Planar Imaging ◽

Element Level

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Analysis of ascending spinal tract degeneration in cervical spondylotic myelopathy using 3D anisotropy contrast single-shot echo planar imaging on a 3.0-T system

Journal of Neurosurgery Spine ◽

10.3171/2011.7.spine10843 ◽

2011 ◽

Vol 15 (6) ◽

pp. 648-653 ◽

Cited By ~ 5

Author(s):

Takaaki Urakawa ◽

Hitoshi Matsuzawa ◽

Yuji Suzuki ◽

Naoto Endo ◽

Ingrid L. Kwee ◽

...

Keyword(s):

Fractional Anisotropy ◽

Cervical Spondylotic Myelopathy ◽

Imaging System ◽

Three Dimensional ◽

Cord Compression ◽

Cervical Cord ◽

Single Shot ◽

Planar Imaging ◽

Contrast Imaging ◽

3.0 T

Object The authors assessed the role of 3D anisotropy contrast (3DAC) in evaluating specific ascending tract degeneration in patients with cervical spondylotic myelopathy (CSM). Methods The authors studied 10 patients (2 women, 8 men; mean age 59.8 ± 14.6 years) with CSM and spinal cord compression below the C2–3 disc level, as well as 10 healthy control individuals (3 women, 7 men; mean age 42.0 ± 24.1 years). Images of the cervical cord at the C2–3 level were obtained using a 3.0-T MR imaging system. Results Three-dimensional anisotropy contrast imaging clearly made possible tract-by-tract analysis of the fasciculus cuneatus, fasciculus gracilis, and spinocerebellar tract. Tract degeneration identified using 3DAC showed good correlation with a decline in fractional anisotropy. Degeneration of the fasciculus gracilis detected by “vector contrast” demonstrated a good correlation with Nurick grades. Conclusions The study unambiguously demonstrated that 3DAC imaging is capable of assessing ascending tract degeneration in patients with CSM. Degeneration of an individual tract can be easily identified as a vector contrast change on the 3DAC image, a reflection of quantitative changes in anisotropism, similar to fractional anisotropy. Excellent correlation between Nurick grades and fasciculus gracilis degeneration suggests potential application of 3DAC imaging for tract-by-tract clinical correlation.

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Gamma Radiation Imaging System via Variable and Time-Multiplexed Pinhole Arrays

Sensors ◽

10.3390/s20113013 ◽

2020 ◽

Vol 20 (11) ◽

pp. 3013 ◽

Cited By ~ 1

Author(s):

Ariel Schwarz ◽

Amir Shemer ◽

Yossef Danan ◽

Rachel Bar-Shalom ◽

Hemy Avraham ◽

...

Keyword(s):

Gamma Radiation ◽

Imaging System ◽

Single Photon ◽

Photon Emission ◽

Three Dimensional ◽

Medical Diagnostics ◽

Emission Computed Tomography ◽

Planar Imaging ◽

Gamma Imaging ◽

Image Capturing

Biomedical planar imaging using gamma radiation is a very important screening tool for medical diagnostics. Since lens imaging is not available in gamma imaging, the current methods use lead collimator or pinhole techniques to perform imaging. However, due to ineffective utilization of the gamma radiation emitted from the patient’s body and the radioactive dose limit in patients, poor image signal to noise ratio (SNR) and long image capturing time are evident. Furthermore, the resolution is related to the pinhole diameter, thus there is a tradeoff between SNR and resolution. Our objectives are to reduce the radioactive dose given to the patient and to preserve or improve SNR, resolution and capturing time while incorporating three-dimensional capabilities in existing gamma imaging systems. The proposed imaging system is based on super-resolved time-multiplexing methods using both variable and moving pinhole arrays. Simulations were performed both in MATLAB and GEANT4, and gamma single photon emission computed tomography (SPECT) experiments were conducted to support theory and simulations. The proposed method is able to reduce the radioactive dose and image capturing time and to improve SNR and resolution. The results and method enhance the gamma imaging capabilities that exist in current systems, while providing three-dimensional data on the object.

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