On the coarse/fine dual-stage manipulators with robust perturbation compensator

2002 ◽  
Author(s):  
SangJoo Kwon ◽  
Wan Kyun Chung ◽  
Youngil Youm
Keyword(s):  
Dual Stage ◽  
Perturbation Compensator

Half- Sandwich cyclopentadienylruthenium(II) Complexes: A New Antimalarial Chemotype

2020 ◽  
Author(s):  
Sofia Alexandra Milheiro ◽  
Joana Gonçalves ◽  
Ricardo Lopes ◽  
Margarida Madureira ◽  
Lis Lobo ◽  
...  
Keyword(s):  
Mammalian Cells ◽  
Blood Stage ◽  
Nuclear Accumulation ◽  
Selective Absorption ◽  
Asexual Parasite ◽  
Single Digit ◽  
Liver Stage ◽  
Dual Stage ◽  
Fluorescent Compounds ◽  
Half Sandwich

<p><a>A small library of “half-sandwich” cyclopentadienylruthenium(II) compounds of general formula [(</a>η<sup>5</sup>-C<sub>5</sub>R<sub>5</sub>)Ru(PPh<sub>3</sub>)(N-N)][PF<sub>6</sub>], a scaffold hitherto unfeatured in the toolbox of antiplasmodials, was screened for activity against the blood stage of CQ-sensitive 3D7-GFP, CQ-resistant Dd2 and artemisinin-resistant IPC5202 <i>Plasmodium falciparum</i> strains, and the liver stage of <i>P. berghei</i>. The best performing compounds displayed dual-stage activity, with single-digit nM IC<sub>50</sub> values against blood stage malaria parasites, nM activity against liver stage parasites, and residual cytotoxicity against mammalian cells (HepG2, Huh7). Parasitic absorption/distribution of 7-nitrobenzoxadiazole-appended fluorescent compounds <b>Ru4</b> and <b>Ru5</b> was investigated by confocal fluorescence microscopy, revealing parasite-selective absorption in infected erythrocytes and nuclear accumulation of both compounds. The lead compound <b>Ru2</b> impaired asexual parasite differentiation, exhibiting fast parasiticidal activity against both ring and trophozoite stages of a synchronized <i>P. falciparum</i> 3D7 strain. These results point to cyclopentadienylruthenium(II) complexes as a highly promising chemotype for the development of dual-stage antiplasmodials.</p>

Dual-stage piezo nanopositioner for high-speed ion conductance microscopy imaging

2020 ◽  
Vol 28 (10) ◽  
pp. 2203-2214
Author(s):  
Jian ZHUANG ◽  
◽  
Zhi-wu WANG ◽  
Xiao-bo LIAO ◽  
Keyword(s):  
High Speed ◽  
Microscopy Imaging ◽  
Ion Conductance ◽  
Dual Stage

Small Molecules Effective Against Liver and Blood Stage Malarial Infection

2019 ◽  
Vol 18 (23) ◽  
pp. 2008-2021 ◽  
Author(s):  
Snigdha Singh ◽  
Neha Sharma ◽  
Charu Upadhyay ◽  
Sumit Kumar ◽  
Brijesh Rathi ◽  
...  
Keyword(s):  
Drug Targets ◽  
Malaria Parasite ◽  
Blood Stage ◽  
Culture Methods ◽  
Liver Stage ◽  
Malarial Infection ◽  
Dual Stage ◽  
New Treatment ◽  
Global Threat

Malaria is a lethal disease causing devastating global impact by killing more than 8,00,000 individuals yearly. A noticeable decline in malaria related deaths can be attributed to the most reliable treatment, ACTs against P. falciparum. However, the cumulative resistance of the malaria parasite against ACTs is a global threat to control the disease and, therefore the new effective therapeutics are urgently needed, including new treatment approaches. Majority of the antimalarial drugs target BS malarial infection. Currently, scientists are eager to explore the drugs with potency against not only BS but other life stages such as sexual and asexual stages of the malaria parasite. Liver Stage is considered as one of the important drug targets as it always leads to BS and the infection can be cured at this stage before it enters into the Blood Stage. However, a limited number of compounds are reported effective against LS malaria infection probably due to scarcity of in vitro LS culture methods and clinical possibilities. This mini review covers a range of chemical compounds showing efficacy against BS and LS of the malaria parasite’s life cycle collectively (i.e. dual stage activity). These scaffolds targeting dual stages are essential for the eradication of malaria and to evade resistance.

scholarly journals Dual Stage Multilevel Control for Heavy Duty Vehicles under Different Traffic Conditions

2020 ◽  
Vol 53 (2) ◽  
pp. 13850-13854
Author(s):  
P. Polverino ◽  
I. Arsie ◽  
C. Pianese
Keyword(s):  
Heavy Duty ◽  
Traffic Conditions ◽  
Dual Stage ◽  
Heavy Duty Vehicles

Development of a dual-stage and visual-servo filming robot

2021 ◽  
pp. 095965182199136
Author(s):  
Liang-Chien Liu ◽  
Ping-Han Yang ◽  
Shih-Chi Liao ◽  
Bing-Peng Li ◽  
Fu-Cheng Wang ◽  
...  
Keyword(s):  
Fast Response ◽  
Tracking Performance ◽  
Visual Servo ◽  
Response Characteristics ◽  
Lower Stage ◽  
Upper Stage ◽  
Dual Stage ◽  
Switching Controller ◽  
Similar Evaluation ◽  
Better Than

This article presents the development of a visual-servo filming robot for dolly & truck style camera movement in filming applications. The robot was implemented with a fast-response slider as the upper stage on top of the slow-response tracked robot body as the lower stage, to improve target tracking performance. A new switching controller was developed, which controlled the stages’ motions by balancing and adjusting the weights of vision error and slider’s noncentering error of the upper stage, thus achieving tracking performance better than the traditional master–slave control strategy. The simulations were carried out to evaluate the tracking performance of the model, particularly focusing on evaluating how the dual stage improves the overall response of the model. The similar evaluation was executed experimentally as well. Both results confirm that the fast-response characteristics of the upper stage can compensate the slow dynamics of lower stage, the tracked robot which is inevitably heavy due to its composition.

scholarly journals Spectral-Spatial Hyperspectral Imagery Classification Using Robust Dual-Stage Spatial Embedding

IEEE Access ◽  
2021 ◽  
pp. 1-1
Author(s):  
Peng Shan ◽  
Zhenqiang Li ◽  
Yi Li ◽  
Wentao Fu
Keyword(s):  
Hyperspectral Imagery ◽  
Dual Stage

scholarly journals Tunable mm-wave A-RoF transmission scheme employing an optical frequency comb and dual-stage active demultiplexer

2021 ◽  
pp. 1-1
Author(s):  
Prajwal D Lakshmijayasimha ◽  
Syed Tajammul Ahmad ◽  
Eamonn Martin ◽  
Anandarajah M Prince ◽  
Aleksandra Maria Kaszubowska-Anandarajah
Keyword(s):  
Frequency Comb ◽  
Optical Frequency Comb ◽  
Optical Frequency ◽  
Transmission Scheme ◽  
Dual Stage

scholarly journals Multi-time Scale Control of Dual-Stage Nanopositioning Systems

2020 ◽  
Vol 53 (2) ◽  
pp. 8631-8637
Author(s):  
Aleksandra Mitrovic ◽  
Milos Milanovic ◽  
Kam K. Leang ◽  
Garrett M. Clayton
Keyword(s):  
Time Scale ◽  
Dual Stage ◽  
Scale Control
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