Toward a Formal Model of Steiner’s Dual Stage Theory of Manufacturing and Retailing

2004 ◽  
Author(s):  
Michael P. Lynch
Keyword(s):  
Formal Model ◽  
Stage Theory ◽  
Dual Stage

Half- Sandwich cyclopentadienylruthenium(II) Complexes: A New Antimalarial Chemotype

2020 ◽  
Author(s):  
Sofia Alexandra Milheiro ◽  
Joana Gonçalves ◽  
Ricardo Lopes ◽  
Margarida Madureira ◽  
Lis Lobo ◽  
...  
Keyword(s):  
Mammalian Cells ◽  
Blood Stage ◽  
Nuclear Accumulation ◽  
Selective Absorption ◽  
Asexual Parasite ◽  
Single Digit ◽  
Liver Stage ◽  
Dual Stage ◽  
Fluorescent Compounds ◽  
Half Sandwich

<p><a>A small library of “half-sandwich” cyclopentadienylruthenium(II) compounds of general formula [(</a>η<sup>5</sup>-C<sub>5</sub>R<sub>5</sub>)Ru(PPh<sub>3</sub>)(N-N)][PF<sub>6</sub>], a scaffold hitherto unfeatured in the toolbox of antiplasmodials, was screened for activity against the blood stage of CQ-sensitive 3D7-GFP, CQ-resistant Dd2 and artemisinin-resistant IPC5202 <i>Plasmodium falciparum</i> strains, and the liver stage of <i>P. berghei</i>. The best performing compounds displayed dual-stage activity, with single-digit nM IC<sub>50</sub> values against blood stage malaria parasites, nM activity against liver stage parasites, and residual cytotoxicity against mammalian cells (HepG2, Huh7). Parasitic absorption/distribution of 7-nitrobenzoxadiazole-appended fluorescent compounds <b>Ru4</b> and <b>Ru5</b> was investigated by confocal fluorescence microscopy, revealing parasite-selective absorption in infected erythrocytes and nuclear accumulation of both compounds. The lead compound <b>Ru2</b> impaired asexual parasite differentiation, exhibiting fast parasiticidal activity against both ring and trophozoite stages of a synchronized <i>P. falciparum</i> 3D7 strain. These results point to cyclopentadienylruthenium(II) complexes as a highly promising chemotype for the development of dual-stage antiplasmodials.</p>

DEVELOPMENT OF A METHOD FOR DESIGNING INFORMATION SYSTEMS FOR ENERGY COMPANIES

2020 ◽  
Vol 5 (333) ◽  
pp. 53-57
Author(s):  
T.B. Aldongar ◽  
◽  
F.U. Malikova ◽  
G.B. Issayeva ◽  
B.R. Absatarova ◽  
...  
Keyword(s):  
Information Systems ◽  
Business Processes ◽  
Design Research ◽  
Graphical Model ◽  
Formal Model ◽  
Workflow Management ◽  
Research Process ◽  
Information Models ◽  
The Creation ◽  
Concept Of Information

The creation of information models requires the use of known methods and the development of new methods of formalizing the pre-design research process. The modeling process consists of four stages: data collection on the object of management - pre-project research; creation of a graphical model of business processes taking place in the enterprise; development of a formal model of business processes; business research by optimizing the formal model. To support the creation of workflow management services and systems, the complex offers methodologies, standards and specialized software that make up the developer's tools. This can be ensured only by modern automated methods based on information systems. It is important that the information collected is structured to meet the needs of potential users and stored in a form that allows the use of modern access technologies. Before discussing the effectiveness of FIM, it should be noted that the basic concept of information itself is still not the same. In a pragmatic way, it is a set of messages in the form of an important document for the system. Information can be evaluated not only by volume, but also by various parameters, the most important of which are: timeliness, relevance, value, aging, accuracy, etc. in addition, the information may be clear, probable and accurate. The methods of its reception and processing are different in each case.

An Information-theoretical Model for Breast Cancer Detection

2008 ◽  
Vol 47 (04) ◽  
pp. 322-327 ◽  
Author(s):  
D. Blokh ◽  
N. Zurgil ◽  
I. Stambler ◽  
E. Afrimzon ◽  
Y. Shafran ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Detection ◽  
Hamming Distance ◽  
Formal Model ◽  
Methodological Approach ◽  
Breast Cancer Detection ◽  
Receptor Expression ◽  
Diagnostic Model ◽  
Model Parameters ◽  
Two Stages

Summary Objectives: Formal diagnostic modeling is an important line of modern biological and medical research. The construction of a formal diagnostic model consists of two stages: first, the estimation of correlation between model parameters and the disease under consideration; and second, the construction of a diagnostic decision rule using these correlation estimates. A serious drawback of current diagnostic models is the absence of a unified mathematical methodological approach to implementing these two stages. The absence of aunified approach makesthe theoretical/biomedical substantiation of diagnostic rules difficult and reduces the efficacyofactual diagnostic model application. Methods: The present study constructs a formal model for breast cancer detection. The diagnostic model is based on information theory. Normalized mutual information is chosen as the measure of relevance between parameters and the patterns studied. The “nearest neighbor” rule is utilized for diagnosis, while the distance between elements is the weighted Hamming distance. The model concomitantly employs cellular fluorescence polarization as the quantitative input parameter and cell receptor expression as qualitative parameters. Results: Twenty-four healthy individuals and 34 patients (not including the subjects analyzed for the model construction) were tested by the model. Twenty-three healthy subjects and 34 patients were correctly diagnosed. Conclusions: The proposed diagnostic model is an open one,i.e.it can accommodate new additional parameters, which may increase its effectiveness.

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