Recent advances for handling imbalancement and uncertainty in labelling in medicinal chemistry data analysis

2016 ◽  
Author(s):  
Joao Carlos Silva de Souza ◽  
Suzana Gomes Claudino ◽  
Rodolfo da Silva Simoes ◽  
Patricia Rufino Oliveira ◽  
Kathia Maria Honorio
Keyword(s):  
Data Analysis ◽  
Medicinal Chemistry ◽  
Chemistry Data ◽  
Recent Advances

scholarly journals Recent Advances in the Development of Sigma Receptor Ligands as Cytotoxic Agents: A Medicinal Chemistry Perspective

2021 ◽  
Author(s):  
Antonino N. Fallica ◽  
Valeria Pittalà ◽  
Maria N. Modica ◽  
Loredana Salerno ◽  
Giuseppe Romeo ◽  
...  
Keyword(s):  
Medicinal Chemistry ◽  
Cytotoxic Agents ◽  
Sigma Receptor ◽  
Receptor Ligands ◽  
Sigma Receptor Ligands ◽  
Recent Advances

Five-Membered Hetarene N-Oxides: Recent Advances in Synthesis and Reactivity

Synthesis ◽  
2021 ◽  
Author(s):  
Leonid Fershtat ◽  
Fedor Teslenko
Keyword(s):  
Transition Metal ◽  
Medicinal Chemistry ◽  
Materials Science ◽  
State Of The Art ◽  
Short Review ◽  
Advanced Materials ◽  
Metal Free ◽  
Recent Advances ◽  
Application Potential ◽  
Metal Catalyzed

Five-membered heterocyclic N-oxides attracted special attention due to their strong application potential in medicinal chemistry and advanced materials science. In this regard, novel methods for their synthesis and functionalization are constantly required. In this short review, recent state-of-the-art achievements in the chemistry of isoxazoline N-oxides, 1,2,3-triazole 1-oxides and 1,2,5-oxadiazole 2-oxides are briefly summarized. Main routes to transition-metal-catalyzed and metal-free functionalization protocols along with mechanistic considerations are outlined. Transformation patterns of the hetarene N-oxide rings as precursors to other nitrogen heterocyclic systems are also presented.

Recent Advances in the Medicinal Chemistry of Farnesoid X Receptor

2021 ◽  
Author(s):  
Yuanying Fang ◽  
Lamees Hegazy ◽  
Brian N. Finck ◽  
Bahaa Elgendy
Keyword(s):  
Medicinal Chemistry ◽  
Farnesoid X Receptor ◽  
Recent Advances

Recent Advances in the Medicinal Chemistry of Liver X Receptors

2018 ◽  
Vol 61 (24) ◽  
pp. 10935-10956 ◽  
Author(s):  
Bahaa El-Dien M. El-Gendy ◽  
Shaimaa S. Goher ◽  
Lamees S. Hegazy ◽  
Mohamed M. H. Arief ◽  
Thomas P. Burris
Keyword(s):  
Medicinal Chemistry ◽  
Liver X Receptors ◽  
Recent Advances ◽  
X Receptors

Recent advances in the synthesis of oxaspirolactones and their application in the total synthesis of related natural products

2019 ◽  
Vol 17 (31) ◽  
pp. 7270-7292 ◽  
Author(s):  
Sagar S. Thorat ◽  
Ravindar Kontham
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Natural Product ◽  
Medicinal Chemistry ◽  
Natural Product Chemistry ◽  
Structural Motifs ◽  
Recent Advances ◽  
Synthetic Molecules ◽  
Product Chemistry

Oxaspirolactones are ubiquitous structural motifs found in natural products and synthetic molecules with a diverse biochemical and physicochemical profile, and represent a valuable target in natural product chemistry and medicinal chemistry.

scholarly journals Chemometrics for ion mobility spectrometry data: recent advances and future prospects

The Analyst ◽  
2016 ◽  
Vol 141 (20) ◽  
pp. 5689-5708 ◽  
Author(s):  
Ewa Szymańska ◽  
Antony N. Davies ◽  
Lutgarde M. C. Buydens
Keyword(s):  
Data Analysis ◽  
Ion Mobility Spectrometry ◽  
Ion Mobility ◽  
Future Prospects ◽  
Comprehensive Review ◽  
Recent Advances ◽  
Chemometric Techniques

This is the first comprehensive review on chemometric techniques used in ion mobility spectrometry data analysis.

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