Cell identification performance based on hierarchical synchronization channels in dense small cell environment

Author(s):  
Hideyuki Morosa ◽  
Hiroki Harada ◽  
Akihito Morimoto ◽  
Satoshi Nasata ◽  
Hiroyuki Ishii ◽  
...  
1967 ◽  
Vol 47 (2) ◽  
pp. 327-341
Author(s):  
DANIEL K. HARTLINE

1. Simultaneous recording from several pairs of electrodes placed along the ganglion and certain efferent nerves, during stimulation of other efferents, allows the course of antidromic impulses in each stimulated axon to be mapped. 2. These impulses disappear as they approach their somata, being incapable of invading them, a fact which permits identification of a particular efferent axon with a particular soma. 3. By these means the courses of all such efferent axons, and their corresponding somata, have been determined. These all belong to the five large cells. 4. The impulses from each such axon occurring during the spontaneous burst can be identified, as can impulses from each small cell. 5. Each large-cell axon appears to be inexcitable until it is a few mm from the soma. 6. If the axon branches within this inexcitable region, the branches tend to fire impulses independently. 7. The technique of cell identification opens the way to a more complete analysis of the ganglion's activity and the synaptic interactions which produce it.


Author(s):  
K.S. McCarty ◽  
N.R. Wallace ◽  
W. Litaker ◽  
S. Wells ◽  
G. Eisenbarth

The production of adrenocorticotropic hormone by non-pituitary carcinomas has been documented in several tumors, most frequently small cell carcinoma of the lung, islet cell carcinomas of the pancreas, thymomas and carcinoids. Electron microscopy of these tumors reveals typical membrane-limited "neurosecretory" granules. Confirmation of the granules as adrenocorticotropin (ACTH) requires the use of OsO4 as a primary fixative to give the characteristic cored granule appearance in conjunction with immunohistochemical demonstration of the hormone peptide. Because of the rarity of ectopic ACTH production by mammary carcinomas and the absence of appropriate ultrastructural studies in the two examples of such ectopic hormone production in the literature of which we are aware (1,2), we present biochemical and ultrastructural data from a carcinoma of the breast with apparent ACTH production.The patient had her primary tumor in the right breast in 1969. The tumor recurred as visceral and subcutaneous metastases in 1976 and again in 1977.


Sign in / Sign up

Export Citation Format

Share Document