scholarly journals Joint T1 and T2 Mapping With Tiny Dictionaries and Subspace-Constrained Reconstruction

2020 ◽  
Vol 39 (4) ◽  
pp. 1008-1014 ◽  
Author(s):  
Volkert Roeloffs ◽  
Martin Uecker ◽  
Jens Frahm
Keyword(s):  
T2 Mapping ◽  
Constrained Reconstruction ◽  
T1 And T2

Cardiac tissue characterization with t1 and t2 mapping in anderson fabry patients: new pathophysiological concepts and early cardiac involvement

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
R Zanoni ◽  
V Ferrara ◽  
G Lanati ◽  
G Vitale ◽  
F Di Nicola ◽  
...  
Keyword(s):  
Cardiac Disease ◽  
Tissue Characterization ◽  
Cardiac Involvement ◽  
Late Onset ◽  
T2 Mapping ◽  
Serum Levels ◽  
Left Ventricular ◽  
Control Group ◽  
Funding Source ◽  
T1 And T2

Abstract Background Anderson Fabry (AF) disease is a X-linked lysosomal storage disorder with multiorgan involvement. Cardiac disease, mainly represented by left ventricular hypertrophy (LVH) and arrhythmias, is the most frequent cause of premature death. It is well know that specific therapy is less effective after the development of LVH and myocardial fibrosis, therefore early cardiac detection (before LVH) is important. New cardiac magnetic resonance (CMR) parametric imaging techniques (T1 and T2 maps) enable myocardial tissue changes associated with AF disease. Purpose To evaluate the relationship between CMR tissue characterization and clinical and instrumental manifestations of AF disease to find early markers of cardiac involvement. Methods 31 AF patients (9 males, mean age 49±16 years) underwent ECG, echocardiogram and contrast CMR. TnI, BNP, pro-BNP and serum lyso-Gb3 were dosed. T1 mapping was performed in a pre-contrast acquisition with the modified Look-Locker inversion recovery (MOLLI) sequences. CMR results were compared with those of 43 healthy age and gender-matched controls. Results In AF patients native septal T1 values were significantly lower compared to healthy controls (median 949 vs 991 msec, p=0.0137) and were inversely related to Lyso-Gb3 serum levels (p=0.003). Patients with LVH had lower T1 septal values in comparison with patients without LVH (892 vs 981 msec; p=0.0012). Patients with classic form had abnormal low T1 values more frequently than pts with late onset variant (78 vs 23%; p=0.038). In AF patients native septal T2 values were significantly higher compared to the control group (53 vs 49 msec; p=0.0004) and correlated with troponin I (p=0.008) and NT-pro BNP (p=0.006) serum levels. No difference was found between pts with and without LVH (53.5 vs 52.5 ms; p=0.797) and the prevalence of abnormal high T2 values was similar between patients with late onset AF and pts with classical form (53% vs 50%; p=1.000). All patients with late onset AF and high T2 values were females. Conclusions CMR T1 (low values) and T2 (high values) mapping are useful tools to detect early cardiac involvement before LVH and to better understand the pathophysiology of cardiac disease in AF patients. Subclinical tissue inflammation, detectable through T2 maps, seems to be an additional pathogenetic mechanism related to the Gb3 storage that contributes to organ damage and precedes LVH, particularly in females patients with late onset phenotype. Funding Acknowledgement Type of funding source: Public hospital(s). Main funding source(s): Sant'Orsola-Malpighi Hospital

T1 and T2 mapping in the identification of acute myocardial injury in patients with NSTEMI

2018 ◽  
Vol 123 (12) ◽  
pp. 926-934 ◽  
Author(s):  
Carlo Tessa ◽  
Jacopo Del Meglio ◽  
Alessio Lilli ◽  
Stefano Diciotti ◽  
Luca Salvatori ◽  
...  
Keyword(s):  
Myocardial Injury ◽  
T2 Mapping ◽  
Acute Myocardial Injury ◽  
T1 And T2

scholarly journals Simultaneous T1 and T2 mapping of hyperpolarized 13C compounds using the bSSFP sequence

2020 ◽  
Vol 312 ◽  
pp. 106691
Author(s):  
Eugene Milshteyn ◽  
Galen D. Reed ◽  
Jeremy W. Gordon ◽  
Cornelius von Morze ◽  
Peng Cao ◽  
...  
Keyword(s):  
T2 Mapping ◽  
Hyperpolarized 13C ◽  
Bssfp Sequence ◽  
T1 And T2

scholarly journals Measurement reproducibility of slice-interleaved T1 and T2 mapping sequences over 20 months: A single center study

PLoS ONE ◽  
2019 ◽  
Vol 14 (7) ◽  
pp. e0220190 ◽  
Author(s):  
Jihye Jang ◽  
Long H. Ngo ◽  
Gabriella Captur ◽  
James C. Moon ◽  
Reza Nezafat
Keyword(s):  
T2 Mapping ◽  
Single Center ◽  
Measurement Reproducibility ◽  
Single Center Study ◽  
T1 And T2 ◽  
Center Study

scholarly journals Myocardial Mapping in Systemic Sarcoidosis: A Comparison of Two Measurement Approaches

2020 ◽  
Vol 193 (01) ◽  
pp. 68-76
Author(s):  
Darius Dabir ◽  
Julian Luetkens ◽  
Daniel Kuetting ◽  
Jennifer Nadal ◽  
Hans Heinz Schild ◽  
...  
Keyword(s):  
T1 Mapping ◽  
Tissue Characterization ◽  
Cardiac Involvement ◽  
T2 Mapping ◽  
Relaxation Times ◽  
Short Axis Slice ◽  
T2 Relaxation ◽  
Standard Mapping ◽  
Systemic Sarcoidosis ◽  
T1 And T2

Purpose To investigate if T1 and T2 mapping is able to differentiate between diseased and healthy myocardium in patients with systemic sarcoidosis, and to compare the standard mapping measurement (measurement within the whole myocardium of the midventricular short axis slice, SAX) to a more standardized method measuring relaxation times within the midventricular septum (ConSept). Materials and Methods 24 patients with biopsy-proven extracardiac sarcoidosis and 17 healthy control subjects were prospectively enrolled in this study and underwent CMR imaging at 1.5 T including native T1 and T2 mapping. Patients were divided into patients with (LGE+) and without (LGE–) cardiac sarcoidosis. T1 and T2 relaxation times were compared between patients and controls. Furthermore, the SAX and the ConSept approach were compared regarding differentiation between healthy and diseased myocardium. Results T1 and T2 relaxation times were significantly longer in all patients compared with controls using both the SAX and the ConSept approach (p < 0.05). However, LGE+ and LGE– patients showed no significant differences in T1 and T2 relaxation times regardless of the measurement approach used (ConSept/SAX) (p > 0.05). Direct comparison of ConSept and SAX T1 mapping showed high conformity in the discrimination between healthy and diseased myocardium (Kappa = 0.844). Conclusion T1 and T2 mapping may not only enable noninvasive recognition of cardiac involvement in patients with systemic sarcoidosis but may also serve as a marker for early cardiac involvement of the disease allowing for timely treatment. ConSept T1 mapping represents an equivalent method for tissue characterization in this population compared to the SAX approach. Further studies including follow-up examinations are necessary to confirm these preliminary results. Key Points:  Citation Format

38 T1 and T2 Mapping Have Higher Diagnostic Accuracy for the Ischaemic Area-at-risk in Nstemi Patients Compared with Dark Blood Imaging

Heart ◽  
2014 ◽  
Vol 100 (Suppl 3) ◽  
pp. A21.1-A21 ◽  
Author(s):  
Samuli Rauhalammi ◽  
Jamie Layland ◽  
David Carrick ◽  
Matthew Lee ◽  
Nadeem Ahmed ◽  
...  
Keyword(s):  
At Risk ◽  
Diagnostic Accuracy ◽  
T2 Mapping ◽  
Area At Risk ◽  
Dark Blood ◽  
T1 And T2 ◽  
Blood Imaging

T1 and T2 mapping in myocarditis: seeing beyond the horizon of Lake Louise criteria and histopathology

2018 ◽  
Vol 16 (5) ◽  
pp. 319-330 ◽  
Author(s):  
Valentina O. Puntmann ◽  
Andreas M. Zeiher ◽  
Eike Nagel
Keyword(s):  
T2 Mapping ◽  
T1 And T2

scholarly journals Left ventricular function recovery in peripartum cardiomyopathy: a cardiovascular magnetic resonance study by myocardial T1 and T2 mapping

2020 ◽  
Vol 22 (1) ◽  
Author(s):  
Yao-Dan Liang ◽  
Yuan-Wei Xu ◽  
Wei-Hao Li ◽  
Ke Wan ◽  
Jia-Yu Sun ◽  
...  
Keyword(s):  
Left Ventricular Function ◽  
Ventricular Function ◽  
T2 Mapping ◽  
Left Ventricular ◽  
Ventricular Ejection Fraction ◽  
Native T1 ◽  
Function Recovery ◽  
Myocardial T1 ◽  
T1 And T2

Abstract Background Peripartum cardiomyopathy (PPCM) is rare and potentially life-threatening; its etiology remains unclear. Imaging characteristics on cardiovascular magnetic resonance (CMR) and their prognostic significance have rarely been studied. We sought to determine CMR’s prognostic value in PPCM by using T1 and T2 mapping techniques. Methods Data from 21 PPCM patients from our CMR registry database were analyzed. The control group comprised 20 healthy age-matched females. All subjects underwent comprehensive contrast-enhanced CMR. T1 and T2 mapping using modified Look-Locker inversion recovery and T2 prep balanced steady-state free precession sequences, respectively. Ventricular size and function, late gadolinium enhancement (LGE), myocardial T1 value, extracellular volume (ECV), and T2 value were analyzed. Transthoracic echocardiography was performed at baseline and during follow-up. The recovered left ventricular ejection fraction (LVEF) was defined as LVEF ≥50% on echocardiography follow-up after at least 6 months of the diagnosis. Results CMR imaging showed that the PPCM patients had severely impaired LVEF and right ventricular ejection fraction (LVEF: 26.8 ± 10.6%; RVEF: 33.9 ± 14.6%). LGE was seen in eight (38.1%) cases. PPCM patients had significantly higher native T1 and ECV (1345 ± 79 vs. 1212 ± 32 ms, P < 0.001; 33.9 ± 5.2% vs. 27.1 ± 3.1%, P < 0.001; respectively) and higher myocardial T2 value (42.3 ± 3.7 vs. 36.8 ± 2.3 ms, P < 0.001) than did the normal controls. After a median 2.5-year follow-up (range: 8 months-5 years), six patients required readmission for heart failure, two died, and 10 showed left ventricular function recovery. The LVEF-recovered group showed significantly lower ECV (30.7 ± 2.1% vs. 36.8 ± 5.6%, P = 0.005) and T2 (40.6 ± 3.0 vs. 43.9 ± 3.7 ms, P = 0.040) than the unrecovered group. Multivariable logistic regression analysis showed ECV (OR = 0.58 for per 1% increase, P = 0.032) was independently associated with left ventricular recovery in PPCM. Conclusions Compared to normal controls, PPCM patients showed significantly higher native T1, ECV, and T2. Native T1, ECV, and T2 were associated with LVEF recovery in PPCM. Furthermore, ECV could independently predict left ventricular function recovery in PPCM.

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