Evidences of aromatic degradation dominantly via the phenylacetic acid pathway in marine benthic Thermoprofundales

2019 ◽  
Vol 22 (1) ◽  
pp. 329-342
Author(s):  
Wei‐Wei Liu ◽  
Jie Pan ◽  
Xiaoyuan Feng ◽  
Meng Li ◽  
Ying Xu ◽  
...  
Keyword(s):  
Phenylacetic Acid ◽  
Aromatic Degradation ◽  
Acid Pathway

THE METABOLISM OF AROMATIC COMPOUNDS WITH DIFFERENT SIDE CHAINS BY A PSEUDOMONAS

1967 ◽  
Vol 13 (7) ◽  
pp. 761-769 ◽  
Author(s):  
E. R. Blakley
Keyword(s):  
Aromatic Ring ◽  
Aromatic Compounds ◽  
Phenylacetic Acid ◽  
Oxidative Degradation ◽  
Homogentisic Acid ◽  
Side Chain ◽  
Hydroxybenzoic Acid ◽  
Side Chains ◽  
Acid Pathway ◽  
Phenylbutyric Acid

A strain of Pseudomonas previously used to study the oxidative degradation of phenylacetic acid and phenylpropionic acid has been used to study the degradation of p-hydroxybenzoic acid, L-tyrosine, L-phenylalanine, phenylbutyric acid, and phenylvaleric acid. p-Hydroxybenzoic acid was converted to 3, 4-dihydroxy-benzoic acid and the aromatic ring was cleaved between carbons 3 and 4. Previous results showed that cleavage of 3, 4-dihydroxyphenylacetic acid occurred between carbons 2 and 3. Phenylalanine and tyrosine were metabolized by the homogentisic acid pathway. These results, together with results of previous work, suggest that the pathway used for the degradation of aromatic compounds by this organism varies with the nature of the side chain. The metabolism of aromatic compounds with side chains longer than three carbons appears to involve oxidative shortening of the side chain prior to cleavage of the aromatic ring.

Chlorobutanol, a Preservative of Desmopressin, Inhibits Human Platelet Aggregation and Release In Vitro

1990 ◽  
Vol 64 (03) ◽  
pp. 473-477 ◽  
Author(s):  
Shih-Luen Chen ◽  
Wu-Chang Yang ◽  
Tung-Po Huang ◽  
Shiang Wann ◽  
Che-ming Teng
Keyword(s):  
Arachidonic Acid ◽  
Platelet Aggregation ◽  
Atp Release ◽  
Free Calcium ◽  
Dependent Manner ◽  
Antiplatelet Effect ◽  
Human Platelet Aggregation ◽  
Acid Pathway ◽  
Arachidonic Acid Pathway

SummaryTherapeutic preparations of desmopressin for parenteral use contain the preservative chlorobutanol (5 mg/ml). We show here that chlorobutanol is a potent inhibitor of platelet aggregation and release. It exhibited a significant inhibitory activity toward several aggregation inducers in a concentration- and time-dependent manner. Thromboxane B2 formation, ATP release, and elevation of cytosolic free calcium caused by collagen, ADP, epinephrine, arachidonic acid and thrombin respectively were markedly inhibited by chlorobutanol. Chlorobutanol had no effect on elastase- treated platelets and its antiplatelet effect could be reversed. It is concluded that the antiplatelet effect of chlorobutanol is mainly due to its inhibition on the arachidonic acid pathway but it is unlikely to have a nonspecitic toxic effect. This antiplatelet effect of chlorobutanol suggests that desmopressin, when administered for improving hemostasis, should not contain chlorobutanol as a preservative.

scholarly journals Studies on the Glucuronic Acid Pathway of Glucose Metabolism

1959 ◽  
Vol 234 (2) ◽  
pp. 250-253
Author(s):  
Frank Eisenberg ◽  
Peter G. Dayton ◽  
J.J. Burns
Keyword(s):  
Glucose Metabolism ◽  
Glucuronic Acid ◽  
Acid Pathway

scholarly journals Completion of the gut microbial epi-bile acid pathway

Gut Microbes ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 1-20
Author(s):  
Heidi L. Doden ◽  
Patricia G. Wolf ◽  
H. Rex Gaskins ◽  
Karthik Anantharaman ◽  
João M. P. Alves ◽  
...  
Keyword(s):  
Bile Acid ◽  
Acid Pathway

THE IONIZATION CONSTANTS OF p-NITROPHENYLACETIC AND PHENYLMALONIC ACIDS

1933 ◽  
Vol 8 (5) ◽  
pp. 447-449 ◽  
Author(s):  
Steward Basterfield ◽  
James W. Tomecko
Keyword(s):  
Benzoic Acid ◽  
Nitro Group ◽  
Malonic Acid ◽  
Phenylacetic Acid ◽  
Ionization Constants ◽  
Side Chain ◽  
Cooh Group ◽  
Conductivity Data ◽  
Nitrobenzoic Acid ◽  
Phenylmalonic Acid

The ionization constants of p-nitrophenylacetic and phenylmalonic acids have been determined from conductivity data. The value of K for p-nitrophenylacetic acid at 25 °C. is 1.04 × 10−4, about twice that of phenylacetic acid. The nitro group in the nucleus has not as powerful an effect on the ionization when the COOH group is in the side chain as it has when both nitro group and COOH are in the nucleus. K for p-nitrobenzoic acid is six times as great as K for benzoic acid. K for phenylmalonic acid is 2. 77 × 10−3 as compared with 1.6 × 10−3 for malonic acid.

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