The Two-Point Threshold

2000 ◽  
Vol 9 (1) ◽  
pp. 29-32 ◽  
Author(s):  
James C. Craig ◽  
Kenneth O. Johnson

The two-point threshold, or compass test, has long been used as a measure of tactile spatial resolution; however, since it was first developed, there have been problems associated with its use. Some of these problems include setting an appropriate criterion for responding “two,” extreme variability both within and between subjects, and the ability of subjects to discriminate two points from one at separations well below the two-point threshold. Recent neurophysiological results have clarified some of the neural mechanisms responsible for spatial resolution and demonstrated the inadequacy of the two-point threshold as a measure of spatial mechanisms. Several new methods may overcome these problems and provide a valid measure of spatial resolution and a reflection of neural mechanisms.

Author(s):  
B. R. Thatch ◽  
A. Myklebust

Abstract Creation of input specifications for synthesis or analysis of spatial mechanisms can be a significant problem. A graphics preprocessor which interactively assists in the definition of spatial mechanism problems is described. New methods of depth cucing and six DOF data entry are presented. To achieve graphics device-independence, the proposed graphics standard PHIGS (Programmer’s Hierarchical Interactive Graphics System) is used. Examples of application are presented including generation of input commands for Integrated Mechanisms Program (IMP) and generation of input for spatial mechanism synthesis routines.


2019 ◽  
Vol 70 (1) ◽  
pp. 199-218
Author(s):  
Joshua D. Morris ◽  
Christine K. Payne

Understanding the cellular basis of human health and disease requires the spatial resolution of microscopy and the molecular-level details provided by spectroscopy. This review highlights imaging methods at the intersection of microscopy and spectroscopy with applications in cell biology. Imaging methods are divided into three broad categories: fluorescence microscopy, label-free approaches, and imaging tools that can be applied to multiple imaging modalities. Just as these imaging methods allow researchers to address new biological questions, progress in biological sciences will drive the development of new imaging methods. We highlight four topics in cell biology that illustrate the need for new imaging tools: nanoparticle-cell interactions, intracellular redox chemistry, neuroscience, and the increasing use of spheroids and organoids. Overall, our goal is to provide a brief overview of individual imaging methods and highlight recent advances in the use of microscopy for cell biology.


2010 ◽  
Vol 27 (1) ◽  
pp. 9-14 ◽  
Author(s):  
Yannick Bleyenheuft ◽  
Pauline Wilmotte ◽  
Jean-Louis Thonnard

Neurology ◽  
2000 ◽  
Vol 55 (10) ◽  
pp. 1597-1597 ◽  
Author(s):  
J. R. Ponsford ◽  
R. W. Van Boven

2006 ◽  
Vol 23 (3-4) ◽  
pp. 83-87 ◽  
Author(s):  
Yannick Bleyenheuft ◽  
Caroline Cols ◽  
Carlyne Arnould ◽  
Jean-Louis Thonnard

1994 ◽  
Vol 12 (3) ◽  
pp. 539-548 ◽  
Author(s):  
O. Renner ◽  
M. Kopecký ◽  
E. Krouský ◽  
E. Förster ◽  
T. Missalla ◽  
...  

Two novel high-dispersion, high-resolution spectroscopic methods are described. The properties of the vertical dispersion variants of the double-crystal spectrometer and the Johann spectrometer with a cylindrically bent crystal are discussed and compared with those of standard spectroscopic schemes. Preliminary experimental data demonstrate the good luminosity and extreme spectral and 1-D spatial resolution of these methods, which should prove useful in high-precision X-ray spectroscopic measurements of laser-produced plasmas.


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