In histopathological study, Lung was emphysematous, showed pronounced interstitial pneumonia followed by severe thickening of alveolar septa and bronchial wall, haemorrhages with connective tissue proliferation and infiltration of leucocytes around the bronchial wall. Bulla formation was also evident in some places. Liver showed mild haemorrhages of hepatocytes and congestion in sinusoidal space. In abomasum, adult parasites were embedded in mucousa and sectioning of adult parasites were seen with full of eggs. In large intestine, there was necrosis and degeneration of colonic villi and lost of normal architecture. There was also evidence of hyperactivity of acinar cells, fibrous tissue proliferation with polymorphonuclear cell infiltration. An apical tip shows degenerative changes, adhesion with mild fibrous tissue proliferation. In small intestine, there was congestion, oedema with thickening of sub mucousa as well as erosion of intestinal villi in certain areas, adhesion and fibrous tissue proliferation. In spleen, there was depletion of spleenic venule, congestion of spleenic pulp, haemorrhages surrounding the spleenic venule.
Inhibition of Connective Tissue Proliferation by Dermal Extract
