Advances in noninvasive methods for diagnosing nonalcoholic fatty liver disease

2016 ◽  
Vol 17 (9) ◽  
pp. 565-571 ◽  
Author(s):  
Fei Fei Shen ◽  
Lun Gen Lu
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Noninvasive Methods ◽  
Nonalcoholic Fatty Liver

scholarly journals Diagnosis and Evaluation of Nonalcoholic Fatty Liver Disease

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Mikako Obika ◽  
Hirofumi Noguchi
Keyword(s):  
Liver Disease ◽  
Liver Biopsy ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Liver Function Tests ◽  
Adverse Outcomes ◽  
Noninvasive Methods ◽  
Nonalcoholic Fatty Liver

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of elevated liver function tests results, after the commonly investigated causes have been excluded, and frequently coexists with type 2 diabetes mellitus (T2DM) because the conditions have common risk factors. As both T2DM and NAFLD are related to adverse outcomes of the other, diagnosis and valuation of fatty liver is an important part of the management of diabetes. Although noninvasive methods, such as biomarkers, panel markers, and imaging, may support a diagnostic evaluation of NAFLD patients, accurate histopathological findings cannot be achieved without a liver biopsy. As it is important to know whether steatohepatitis and liver fibrosis are present for the management of NAFLD, liver biopsy remains the gold standard for NAFLD diagnosis and evaluation. Therefore, new investigations of the pathogenesis of NAFLD are necessary to develop useful biomarkers that could provide a reliable noninvasive alternative to liver biopsy.

scholarly journals The Role of Long Non-Coding RNAs (lncRNAs) in the Development and Progression of Fibrosis Associated with Nonalcoholic Fatty Liver Disease (NAFLD)

2018 ◽  
Vol 4 (3) ◽  
pp. 18 ◽  
Author(s):  
Amanda Hanson ◽  
Danielle Wilhelmsen ◽  
Johanna DiStefano
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Molecular Mechanisms ◽  
Disease Diagnosis ◽  
Noninvasive Methods ◽  
Nonalcoholic Fatty Liver ◽  
Potential Applicability ◽  
Non Coding Rnas

Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of conditions ranging from hepatic steatosis to inflammation (nonalcoholic steatohepatitis or NASH) with or without fibrosis, in the absence of significant alcohol consumption. The presence of fibrosis in NASH patients is associated with greater liver-related morbidity and mortality; however, the molecular mechanisms underlying the development of fibrosis and cirrhosis in NAFLD patients remain poorly understood. Long non-coding RNAs (lncRNAs) are emerging as key contributors to biological processes that are underpinning the initiation and progression of NAFLD fibrosis. This review summarizes the experimental findings that have been obtained to date in animal models of liver fibrosis and NAFLD patients with fibrosis. We also discuss the potential applicability of circulating lncRNAs to serve as biomarkers for the diagnosis and prognosis of NAFLD fibrosis. A better understanding of the role played by lncRNAs in NAFLD fibrosis is critical for the identification of novel therapeutic targets for drug development and improved, noninvasive methods for disease diagnosis.

Iron-Overload Evaluation by Noninvasive Methods in Patients with Nonalcoholic Fatty Liver Disease, Overweight, and Hyperferritinemia

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 292-LB ◽  
Author(s):  
PAULA P.F. BRANISSO ◽  
CLAUDIA P. OLIVEIRA ◽  
HILTON M. LEÃO FILHO ◽  
ARITANIA SANTOS ◽  
FABIANA R. LIMA ◽  
...  
Keyword(s):  
Liver Disease ◽  
Iron Overload ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Noninvasive Methods ◽  
Nonalcoholic Fatty Liver

The search for noninvasive methods to identify liver fibrosis in children with nonalcoholic fatty liver disease

2018 ◽  
Vol 12 (3) ◽  
pp. 265-273 ◽  
Author(s):  
Chetan Mandelia ◽  
Mohammad Nasser Kabbany ◽  
Praveen Kumar Conjeevaram Selvakumar ◽  
Naim Alkhouri
Keyword(s):  
Liver Disease ◽  
Liver Fibrosis ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Noninvasive Methods ◽  
Nonalcoholic Fatty Liver

scholarly journals Nonalcoholic fatty liver disease: Noninvasive methods of diagnosing hepatic steatosis

2015 ◽  
Vol 21 (2) ◽  
pp. 64 ◽  
Author(s):  
Mazen Hassanain ◽  
Peter Metrakos ◽  
Said Al-Busafi ◽  
Murad Aljiffry ◽  
Rasha AlShaalan
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Hepatic Steatosis ◽  
Fatty Liver Disease ◽  
Noninvasive Methods ◽  
Nonalcoholic Fatty Liver

scholarly journals Diagnostic Assessment of Nonalcoholic Fatty Liver Disease

2020 ◽  
Vol 95 (5) ◽  
pp. 299-307
Author(s):  
Young-Joo Jin
Keyword(s):  
Differential Diagnosis ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Diagnostic Assessment ◽  
Noninvasive Methods ◽  
Nonalcoholic Fatty Liver ◽  
Disease Spectrum ◽  
Sample Error

Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, and is characterized by fat accumulation at levels exceeding 5% in hepatocytes due to insulin resistance. The disease spectrum ranges from simple nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH)/NASH-related fibrosis or cirrhosis defined by histological findings. Unlike simple NAFL, NASH/NASH-related fibrosis or cirrhosis increases the risk of liver-related morbidity or mortality. Therefore, accurate diagnosis of NASH/NASH-related fibrosis or cirrhosis is needed for management of patients with these diseases. Currently, liver biopsy is the only way to confirm the presence of NASH in an individual with features of NAFLD, but this has some limitations, including sample error, interpretation error, and the invasiveness of the procedure. Therefore, there have been a number of attempts to develop noninvasive methods for differential diagnosis of NASH/NASH-related fibrosis or cirrhosis easily and quickly. Here, we review the assessments for diagnosing NAFLD and the methods for differential diagnosis of NASH/NASH-related fibrosis or cirrhosis.

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