Word of mouth: oral mucosa composition in health and immune disease

Oral Mucosa Lichen Planus: Case Presentation

Surgery Current Trends and Innovations ◽

10.24966/scti-7284/100024 ◽

2019 ◽

Vol 3 (3) ◽

pp. 1

Author(s):

Leroy Olaechea Varona ◽

Keyword(s):

Lichen Planus ◽

Oral Mucosa ◽

Immune Disease ◽

Case Presentation ◽

Mucous Membranes ◽

White Scale

Lichen planus is a chronic inflammatory and immune disease that affects the skin, nails, hair, and mucous membranes. It is characterized by polygonal, flat-topped, violaceous papules and plaques with overlying, reticulated, fine white scale (Wickham’s striae), commonly affecting dorsal hands, flexural wrists and forearms, trunk, anterior lower legs and mucosa membranes

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Labial vitiligo associated with a factice disorder: a case report

Journal of Oral Medicine and Oral Surgery ◽

10.1051/mbcb/2018010 ◽

2018 ◽

Vol 24 (4) ◽

pp. 167-169

Author(s):

Margaux Fricain ◽

Pierre Weidmann ◽

Yvon Roche ◽

Jean Christophe Fricain

Keyword(s):

Folic Acid ◽

Case Report ◽

Vitamin C ◽

Oral Mucosa ◽

Clinical Examination ◽

North Africa ◽

Skin Involvement ◽

Upper Lip ◽

Immune Disease ◽

Sharp Edges

Introduction: Vitiligo is a non-contagious leukoderma. The loss of melanocytes result in a local hypopigmentation like white symmetrical plaques with sharp edges, most of the time surrounded by hyperpigmentation. It might be an auto immune disease with a genetic predisposition linked to psychological disorders. Oral mucosa vitiligo has rarely been described in the literature. Observation: A seventeen years old patient, native from North Africa, has consulted for a half left upper lip depigmentation appeared in October 2016. The dermatologist had made the diagnosis of vitiligo and prescribed vitamin C and folic acid, without any result. In July 2017, as the lesion has extended to the whole upper lip, the patient came to oral mucosa pathology consultation. Anamnesis revealed a chronic lips chewing. Clinical examination revealed a linear vermillion border depigmentation of the upper lip associated with peripheral pigment enhancement, as well as digital cutaneous involvement. The prescribed treatment was: tacrolimus 0.1% twice daily in local application, stopping practice disorder and sun protection. Comment: Diagnosis of vitiligo is based on clinical examination that can differentiate a segmental vitiligo (localized on at least one dermatomes) of a non-segmental vitiligo (acrofacial, generalized, universalis). Vitiligo of the oral mucosa is rare. It has mainly been described in India. Oral mucosa involvement would affect 55% of patient and the lip would be affected in almost one in two cases in this population. Conclusion: Oral mucosa vitiligo must be known by oral surgeon who has to master the diagnosis and treatments in association with dermatologist, given the concomitant skin involvement that is almost mandatory.

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Induction and Differentiation of Dental Epithelium in Vivo and in Vitro

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100053425 ◽

1982 ◽

Vol 40 ◽

pp. 142-145

Author(s):

E. J. Kollar

Keyword(s):

Connective Tissue ◽

Oral Mucosa ◽

Basal Lamina ◽

Functional Derivatives ◽

Specific Source ◽

Dental Epithelium ◽

Connective Tissue Stroma

The differentiation and maintenance of many specialized epithelial structures are dependent on the underlying connective tissue stroma and on an intact basal lamina. These requirements are especially stringent in the development and maintenance of the skin and oral mucosa. The keratinization patterns of thin or thick cornified layers as well as the appearance of specialized functional derivatives such as hair and teeth can be correlated with the specific source of stroma which supports these differentiated expressions.

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Dupuytren's Contracture and Microvessels

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100098848 ◽

1981 ◽

Vol 39 ◽

pp. 470-471

Author(s):

C. W. Klscher ◽

D. Speer

Keyword(s):

Hypertrophic Scar ◽

Active Form ◽

Scar Tissue ◽

Vascular Supply ◽

Fiber Bundles ◽

Dupuytren’S Contracture ◽

Palmar Fascia ◽

Immune Disease ◽

Dupuytren's Contracture ◽

Longitudinal Fiber

Dupuytren's Contracture is a nodular proliferation of the longitudinal fiber bundles of palmar fascia with its attendant contraction. The factors attributed to its etiology have included trauma, diabetes, alcoholism, arthritis, and auto-immune disease. The tissue has been observed by electron microscopy and found to contain myofibroblasts.Dupuytren's Contracture constitutes a scar, and as such, excessive collagen can be observed, along with an active form of fibroblast.Previous studies of the hypertrophic scar have led us to propose that integral in the initiation and sustenance of scar tissue is a profusion of microvascular regeneration, much of which becomes and remains occluded producing a hypoxia which stimulates fibroblast synthesis. Thus, when considering a study of Dupuytren's Contracture, we predicted finding occluded microvessels at or near the fascial scarring focus.Three cases of Dupuytren's Contracture yielded similar specimens, which were fixed in Karnovskys fluid for 2 to 20 days. Upon removal of the contracture bands care was taken to include the contiguous fatty and areolar tissue which contain the vascular supply and to identify the junctional area between old and new fascia.

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The effects of Cyclosporin-A (CYA) on the Ultrastructure of Gingival Mast Cells (GMC) in Behcet's disease (BD)

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100159333 ◽

1990 ◽

Vol 48 (3) ◽

pp. 358-359

Author(s):

Oktay Arda ◽

Ulkü Noyan ◽

Selgçk Yilmaz ◽

Mustafa Taşyürekli ◽

İsmail Seçkin ◽

...

Keyword(s):

Unknown Etiology ◽

Control Group ◽

Target Cells ◽

Gingival Hyperplasia ◽

Cellular Activity ◽

Direct Relation ◽

Immune Disease ◽

Genital Ulceration ◽

Functional Changes ◽

The Third

Turkish dermatologist, H. Beheet described the disease as recurrent triad of iritis, oral aphthous lesions and genital ulceration. Auto immune disease is the recent focus on the unknown etiology which is still being discussed. Among the other immunosupressive drugs, CyA included in it's treatment newly. One of the important side effects of this drug is gingival hyperplasia which has a direct relation with the presence of teeth and periodontal tissue. We are interested in the ultrastructure of immunocompetent target cells that were affected by CyA in BD.Three groups arranged in each having 5 patients with BD. Control group was the first and didn’t have CyA treatment. Patients who had CyA, but didn’t show gingival hyperplasia assembled the second group. The ones displaying gingival hyperplasia following CyA therapy formed the third group. GMC of control group and their granules are shown in FIG. 1,2,3. GMC of the second group presented initiation of supplementary cellular activity and possible maturing functional changes with the signs of increased number of mitochondria and accumulation of numerous dense cored granules next to few normal ones, FIG. 4,5,6.

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